MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER

Emin Özlü; Ragıp Ertaş

MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER

Öz

Mikozis fungoides (MF) en sık görülen kutane T hücreli lenfoma (KTHL) formudur. Hastalık yavaş seyirliden agresif hızlı seyirli formlara kadar değişken klinik seyri vardır. MF tedavisinde birçok alternatif mevcuttur ve deriyi hedefleyen tedavilerden kemoterapiye kadar değişen farklı yöntemler tedavide kullanılır. Retinoidler hücre proliferasyonu, diferansiyasyonu ve apoptozisi düzenleyen ve immün yanıtı etkileyen A vitamini türevleridir. Retinoidler MF tedavisinde uzun yıllardır kullanılmaktadır ancak etki mekanizması belirsizliğini korumaktadır. Retinoidler uygulama kolaylığı ve nispeten düşük toksisite profili nedeniyle MF’in tüm evrelerinde tedavi seçeneklerinin önemli bir bileşenidir. Beksaroten KTHL tedavisinde Gıda ve İlaç İdaresi (FDA) tarafından onaylanan ilk retinoiddir. MF tedavisinde retinoidlerin diğer ajanlarla kombinasyonu iyi tolere edilir ve nükseden, dirençli hastalarda daha yüksek tedavi cevabı ile ilişkilidir. Bu derlemede, MF hastalarında retinoidlerin kullanımı ile ilgili litetarür bilgileri gözden geçirlmiştir.

Anahtar Kelimeler

Mikozis fungoides,retinoidler,tedavi

References

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Details

Primary Language

Turkish

Subjects

-

Journal Section

Review

Authors

Emin Özlü

Ragıp Ertaş This is me

Publication Date

April 6, 2018

Submission Date

March 12, 2018

Acceptance Date

March 17, 2018

Published in Issue

Year 1970 Volume: 3 Number: 1

IZ

https://izlik.org/JA95CX56WS

Cite

RIS / Bibtex

APA

Özlü, E., & Ertaş, R. (2018). MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. Güncel Dermatoloji Dergisi, 3(1), 10-16. https://izlik.org/JA95CX56WS

AMA

1.Özlü E, Ertaş R. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD. 2018;3(1):10-16. https://izlik.org/JA95CX56WS

Chicago

Özlü, Emin, and Ragıp Ertaş. 2018. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi 3 (1): 10-16. https://izlik.org/JA95CX56WS.

EndNote

Özlü E, Ertaş R (April 1, 2018) MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. Güncel Dermatoloji Dergisi 3 1 10–16.

IEEE

[1]E. Özlü and R. Ertaş, “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”, GDD, vol. 3, no. 1, pp. 10–16, Apr. 2018, [Online]. Available: https://izlik.org/JA95CX56WS

ISNAD

Özlü, Emin - Ertaş, Ragıp. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi 3/1 (April 1, 2018): 10-16. https://izlik.org/JA95CX56WS.

JAMA

1.Özlü E, Ertaş R. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD. 2018;3:10–16.

MLA

Özlü, Emin, and Ragıp Ertaş. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi, vol. 3, no. 1, Apr. 2018, pp. 10-16, https://izlik.org/JA95CX56WS.

Vancouver

1.Emin Özlü, Ragıp Ertaş. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD [Internet]. 2018 Apr. 1;3(1):10-6. Available from: https://izlik.org/JA95CX56WS