MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER

Emin Özlü; Ragıp Ertaş

MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER

Öz

Mikozis fungoides (MF) en sık görülen kutane T hücreli lenfoma (KTHL) formudur. Hastalık yavaş seyirliden agresif hızlı seyirli formlara kadar değişken klinik seyri vardır. MF tedavisinde birçok alternatif mevcuttur ve deriyi hedefleyen tedavilerden kemoterapiye kadar değişen farklı yöntemler tedavide kullanılır. Retinoidler hücre proliferasyonu, diferansiyasyonu ve apoptozisi düzenleyen ve immün yanıtı etkileyen A vitamini türevleridir. Retinoidler MF tedavisinde uzun yıllardır kullanılmaktadır ancak etki mekanizması belirsizliğini korumaktadır. Retinoidler uygulama kolaylığı ve nispeten düşük toksisite profili nedeniyle MF’in tüm evrelerinde tedavi seçeneklerinin önemli bir bileşenidir. Beksaroten KTHL tedavisinde Gıda ve İlaç İdaresi (FDA) tarafından onaylanan ilk retinoiddir. MF tedavisinde retinoidlerin diğer ajanlarla kombinasyonu iyi tolere edilir ve nükseden, dirençli hastalarda daha yüksek tedavi cevabı ile ilişkilidir. Bu derlemede, MF hastalarında retinoidlerin kullanımı ile ilgili litetarür bilgileri gözden geçirlmiştir.

Anahtar Kelimeler

Mikozis fungoides,retinoidler,tedavi

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Emin Özlü

Ragıp Ertaş Bu kişi benim

Yayımlanma Tarihi

6 Nisan 2018

Gönderilme Tarihi

12 Mart 2018

Kabul Tarihi

17 Mart 2018

Yayımlandığı Sayı

Yıl 1970 Cilt: 3 Sayı: 1

IZ

https://izlik.org/JA95CX56WS

Kaynak Göster

RIS / Bibtex

APA

Özlü, E., & Ertaş, R. (2018). MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. Güncel Dermatoloji Dergisi, 3(1), 10-16. https://izlik.org/JA95CX56WS

AMA

1.Özlü E, Ertaş R. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD. 2018;3(1):10-16. https://izlik.org/JA95CX56WS

Chicago

Özlü, Emin, ve Ragıp Ertaş. 2018. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi 3 (1): 10-16. https://izlik.org/JA95CX56WS.

EndNote

Özlü E, Ertaş R (01 Nisan 2018) MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. Güncel Dermatoloji Dergisi 3 1 10–16.

IEEE

[1]E. Özlü ve R. Ertaş, “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”, GDD, c. 3, sy 1, ss. 10–16, Nis. 2018, [çevrimiçi]. Erişim adresi: https://izlik.org/JA95CX56WS

ISNAD

Özlü, Emin - Ertaş, Ragıp. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi 3/1 (01 Nisan 2018): 10-16. https://izlik.org/JA95CX56WS.

JAMA

1.Özlü E, Ertaş R. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD. 2018;3:10–16.

MLA

Özlü, Emin, ve Ragıp Ertaş. “MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER”. Güncel Dermatoloji Dergisi, c. 3, sy 1, Nisan 2018, ss. 10-16, https://izlik.org/JA95CX56WS.

Vancouver

1.Emin Özlü, Ragıp Ertaş. MİKOZİS FUNGOİDES TEDAVİSİNDE RETİNOİDLER. GDD [Internet]. 01 Nisan 2018;3(1):10-6. Erişim adresi: https://izlik.org/JA95CX56WS