Year 2016,
Volume: 1 Issue: 1, 18 - 23, 12.08.2016
Abstract
Bazal hücreli kanser (BCC) derinin en sık görülen kanseridir. Nadir metastaz yapmasına rağmen lokal destrüksiyon yapmasından dolayı önemli bir morbidite nedenidir. Güneş ışığına maruziyet en önemli risk faktörüdür. Son yıllarda BCC patogenezini aydınlatma adına önemli ilerlemeler kaydedilmiştir. Hemen hepsinde olmasa da birçok BCC olgusunda Hedgehog sinyalinin aktivasyonunda artış saptanmakta ve bu da ileri evre hastalıkta hedefe yönelik tedavilerin geliştirilmesine olanak sağlamaktadır.
Keywords
References
- REFERANSLAR
- Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer 2008; 8: 743-54.
- Mancuso M, Pazzaglia S, Tanori M, Hahn H, Merola P, et al. Basal cell carcinoma and its development: Insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res 2004; 64: 934-41.
- Gunes AT, Akarsu S. Bazoselüler karsinom. Turkiye Klinikleri J Dermatol-Special Topics 2013; 6: 1-10.
- Bauer A, Diepgen TL, Schmitt J. Is occupational solar ultraviolet irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiological literature. Br J Dermatol 2011; 165: 612-25.
- Quamous Wisgerhof HC, Edelbroek JR, de Filter JW, et al. Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010; 89: 1231-8.
- Marghoob AA. Skin cancers and their etiologies. Semin Cutan Med surg 2011; 30: S1-5.
- Sehgal VN, Chatterjee K, Pandhi D. Basal cell carcinoma: Pathophysiology. Skinmed 2014; 12: 176-81.
- Caro I, Low JA. The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. Canser Res 2010; 16: 3335-9.
- Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. Hedgehog signalling in skin development and cancer. Exp Dermatol 2006; 15: 667-77.
- Lee Y, Miller HL, Russell HR, et al. Patched 2 modulates tumorigenesis in patched 1 heterozygous mice. Cancer Res. 2006; 66:6964-71.
- Teglund S, Toftgard R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 2010; 1805: 181-208.
- Fecher LA, Sharfman WH. Advanced basal cell carcinoma, the hedgehog pathway, and treatment options—role of smoothened inhibitors. Biologics Targets Therapy 2015; 9: 129-40.
- Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against smoothened antagonists. Cancer Res 2011; 71: 5057-61.
- Marzuka AG, Book SE. Basal cell carcinoma: Pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management. Yale J Bıology Medicıne 2015; 88: 167-79.
Year 2016,
Volume: 1 Issue: 1, 18 - 23, 12.08.2016
Abstract
References
- REFERANSLAR
- Epstein EH. Basal cell carcinomas: attack of the hedgehog. Nat Rev Cancer 2008; 8: 743-54.
- Mancuso M, Pazzaglia S, Tanori M, Hahn H, Merola P, et al. Basal cell carcinoma and its development: Insights from radiation-induced tumors in Ptch1-deficient mice. Cancer Res 2004; 64: 934-41.
- Gunes AT, Akarsu S. Bazoselüler karsinom. Turkiye Klinikleri J Dermatol-Special Topics 2013; 6: 1-10.
- Bauer A, Diepgen TL, Schmitt J. Is occupational solar ultraviolet irradiation a relevant risk factor for basal cell carcinoma? A systematic review and meta-analysis of the epidemiological literature. Br J Dermatol 2011; 165: 612-25.
- Quamous Wisgerhof HC, Edelbroek JR, de Filter JW, et al. Subsequent squamous- and basal-cell carcinomas in kidney-transplant recipients after the first skin cancer: cumulative incidence and risk factors. Transplantation 2010; 89: 1231-8.
- Marghoob AA. Skin cancers and their etiologies. Semin Cutan Med surg 2011; 30: S1-5.
- Sehgal VN, Chatterjee K, Pandhi D. Basal cell carcinoma: Pathophysiology. Skinmed 2014; 12: 176-81.
- Caro I, Low JA. The role of the hedgehog signaling pathway in the development of basal cell carcinoma and opportunities for treatment. Canser Res 2010; 16: 3335-9.
- Athar M, Tang X, Lee JL, Kopelovich L, Kim AL. Hedgehog signalling in skin development and cancer. Exp Dermatol 2006; 15: 667-77.
- Lee Y, Miller HL, Russell HR, et al. Patched 2 modulates tumorigenesis in patched 1 heterozygous mice. Cancer Res. 2006; 66:6964-71.
- Teglund S, Toftgard R. Hedgehog beyond medulloblastoma and basal cell carcinoma. Biochim Biophys Acta 2010; 1805: 181-208.
- Fecher LA, Sharfman WH. Advanced basal cell carcinoma, the hedgehog pathway, and treatment options—role of smoothened inhibitors. Biologics Targets Therapy 2015; 9: 129-40.
- Metcalfe C, de Sauvage FJ. Hedgehog fights back: mechanisms of acquired resistance against smoothened antagonists. Cancer Res 2011; 71: 5057-61.
- Marzuka AG, Book SE. Basal cell carcinoma: Pathogenesis, epidemiology, clinical features, diagnosis, histopathology, and management. Yale J Bıology Medicıne 2015; 88: 167-79.
There are 15 citations in total.
Details
| Journal Section | Güncel Derlemeler |
|---|---|
| Authors | |
| Publication Date | August 12, 2016 |
| Published in Issue | Year 2016 Volume: 1 Issue: 1 |