Merkel hücreli karsinom

Year 2017, Volume: 2 Issue: 3, 69 - 71, 24.12.2017

Banu Taşkın

Abstract

ABSTRACT

Merkel-cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin. Incidence rates of MCC have increased in past decades. MCC presents as a firm red to livid tumor with a smooth, shiny surface. Satellite metastases can occur quite early but ulcerations are very rare. Light microscopy and immunohistochemical examination are used in the diagnosis of the tumor. Large local excision and sentinel lymph node biopsy is recommended for the treatment. Adjuvant radiotherapy reduces regional recurrence rates.

 

ÖZET

Merkel hücreli karsinom (MKH) nadir görülen, agresif seyirli, nöroendokrin bir deri tümörüdür. İnsidansı son dekatlarda artış göstermektedir. MHK sert, eritemli-viyolase, parlak yüzeyli nodül şeklinde ortaya çıkmaktadır. Kısa sürede satellit metastaz geliştirir ancak ülserasyon nadiren eşlik eder. Tanıda ışık mikroskopisi ve immunohistokimyasal incelemeler kullanılır. Tedavide geniş lokal eksizyon yapılması ve sentinel lenf nodu biyopsisi önerilmektedir. Adjuvan radyoterapi bölgesel rekürrens oranlarını azaltmaktadır.

Keywords

skin cancer, diagnosis, surgical management, adjuvant radiotherapy, Merkel hücreli karsinom

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