Merkel hücreli karsinom

Yıl 2017, Cilt: 2 Sayı: 3, 69 - 71, 24.12.2017

Banu Taşkın

Öz

ABSTRACT

Merkel-cell carcinoma (MCC) is a highly aggressive neuroendocrine carcinoma of the skin. Incidence rates of MCC have increased in past decades. MCC presents as a firm red to livid tumor with a smooth, shiny surface. Satellite metastases can occur quite early but ulcerations are very rare. Light microscopy and immunohistochemical examination are used in the diagnosis of the tumor. Large local excision and sentinel lymph node biopsy is recommended for the treatment. Adjuvant radiotherapy reduces regional recurrence rates.

 

ÖZET

Merkel hücreli karsinom (MKH) nadir görülen, agresif seyirli, nöroendokrin bir deri tümörüdür. İnsidansı son dekatlarda artış göstermektedir. MHK sert, eritemli-viyolase, parlak yüzeyli nodül şeklinde ortaya çıkmaktadır. Kısa sürede satellit metastaz geliştirir ancak ülserasyon nadiren eşlik eder. Tanıda ışık mikroskopisi ve immunohistokimyasal incelemeler kullanılır. Tedavide geniş lokal eksizyon yapılması ve sentinel lenf nodu biyopsisi önerilmektedir. Adjuvan radyoterapi bölgesel rekürrens oranlarını azaltmaktadır.

Anahtar Kelimeler

skin cancer, diagnosis, surgical management, adjuvant radiotherapy, Merkel hücreli karsinom

Kaynakça

• 1. Toker, C. Trabecular carcinoma of the skin. Arch. Dermatol 1972; 105, 107-10.
• 2. Allen PJ, Bowne WB, Jaques DP, et al. Merkel cell carcinoma: prognosis and treatment of patients from a single institution. J Clin Oncol 2005; 23: 2300-9.
• 3. Girschik J, Thorn K, Beer TW, et al. Merkel cell carcinoma in Western Australia: a population-based study of incidence and survival. Br J Dermatol 2011; 165: 1051-7.
• 4. Lebbe C, Becker JC, Grob JJ, et al. Diagnosis and treatment of Merkel Cell Carcinoma. European consensus-based interdisciplinary guideline. Eur J Cancer 2015; 51: 2396-403.
• 5. Heath M, Jaimes N, Lemos B, et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol 2008; 58: 375-81.
• 6. Medina-Franco H, Urist MM, Fiveash J, et al. Multimodality treatment of Merkel cell carcinoma: case series and literature review of 1024 cases. Ann Surg Oncol 2001; 8: 204-8.
• 7. Kuwamoto S. Recent advances in the biology of Merkel cell carcinoma. Hum Pathol 2011; 42: 1063-77.
• 8. Lemos BD, Storer BE, Iyer JG, et al. Pathologic nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol 2010; 63: 751-61.
• 9. Veness MJ1, Perera L, Mc Court J, et al. Merkel cell carcinoma: improved outcome with adjuvant radiotherapy. ANZ J Surg 2005; 75: 275-81.
• 10. Lewis KG1, Weinstock MA, Weaver AL, et al. Adjuvant local irradiation for Merkel cell carcinoma. Arch Dermatol. 2006; 142: 693-700.
• 11. Llombart B, Kindem S, Chust M. Merkel cell carcinoma: An update of key imaging techniques, prognostic factors, treatment and follow up. Actas Dermosifiliogr 2017; 108: 98-107.