Gastroözefageal Reflü Hastalığı ile Tıkınırcasına Yeme Bozukluğu Arasındaki İlişki

Year 2021, , 380 - 384, 15.12.2021

Akın Çalışır Saliha Çalışır Mustafa Şahin Hasan Maden Hüsnü Alptekin

https://doi.org/10.54005/geneltip.1036720

Abstract

Amaç

Gastroözefageal reflü hastalığı, asit mide içeriğinin efor sarf etmeksizin özefagusa geri gelmesi ile ortaya çıkan bir hastalıktır ve günümüzde beslenme alışkanlıklarının değişmesiyle sıklığı giderek artmaktadır. Bu çalışma ile en sık görülen yeme bozukluğu olan tıkınırcasına yeme bozukluğu ile gastroözefageal reflü hastalığı arasındaki ilişki olup olmadığını ortaya koyulması amaçlanmıştır.

Metod

2011 ve 2018 yılları arasında gastroözefageal reflü hastalğı nedeniyle 24 saatlik pH monitörizasyon işlemi yapılan hastaların dosyaları geriye dönük olarak incelendi. Çalışmaya katılmayı kabul eden 305 hastaya ve aynı sayıda sağlıklı kontrol grubuna tıkınarcasına yeme bozukluğu tanı anketi yapıldı. Her iki grup arasında demografik veriler ve tıkınırcasına yeme bozukluğu tanısı açısından karşılaştırma yapıldı. Ayrıca tıkınırcasına yeme bozukluğu tanısı konulan hastaların 24 saatlik pH monitörizasyon verileri diğer reflü hastaları ile karşılaştırıldı.

Sonuç

Vücut kitle indeksi yüksekliği ve sigara kullanımı, gastroözefagal reflü grubunda daha yüksek bulundu. Yaş ve cinsiyet açısından her iki grup arasında anlamlı bir fark izlenmedi. Tıkınırcasına yeme bozukluğu olan hastalarda toplam reflü zamanı, uzun reflü periyod sayısı, en uzun reflü ve DeMeester skoru anlamlı derecede yüksek bulundu.

Keywords

Gastroözefageal reflü, Tıkınırcasına yeme, 24-h pH monitörizasyonu

The Relationship Between Gastroesophageal Reflux Disease and Binge Eating Disorder

Abstract

Purpose

Gastroesophageal reflux disease is a common condition that is characterized with esophageal mucosal injury secondary to gastric acid reflux. The aim of this study is to reveal whether there is a relationship between binge eating disorder and gastroesophageal reflux disease.

Methods

Patients with gastroesophageal reflux disease who underwent 24-h esophageal pH monitoring between 2016 and 2018 were evaluated retrospectively. Binge eating disorder diagnosis questionnaire was applied to 305 patients of these who agreed to participate in the study. The same questionnaire was applied to the control group consisting of the same number of healthy participants. A comparison was made between both groups in terms of demographic data and diagnosis of binge eating disorder. Also, 24-hour pH monitoring data of the patients diagnosed with binge eating disorder were compared with other reflux patients.

Results

In the gastroesophageal reflux group, smoking incidence and higher body mass index was significantly more common. There was no significant difference between the two groups in terms of age and gender. Total reflux time, number of long reflux periods, longest reflux and DeMeester score were found to be significantly higher in patients with binge eating disorder.

Keywords

Gastroesophageal reflux, Binge eating, 24-h pH monitor

References

• Dobrucalı A. Gastroözofagial Reflü Hastalığı ve Teşhis ve Tedavide Karşılaşılan Sorunlar. Sempozyum Dizisi. 2007;58:9-30.
• Kahrilas PJ. GERD pathogenesis, pathophysiology, and clinical manifestations. Cleveland Clinic journal of medicine. 2003;70(5):S4.
• Tack J, Becher A, Mulligan C, Johnson D. Systematic review: the burden of disruptive gastro‐oesophageal reflux disease on health‐related quality of life. Alimentary pharmacology & therapeutics. 2012;35(11):1257-66.
• Locke 3rd G, Talley NJ, Fett SL, Zinsmeister AR, Melton 3rd L. Prevalence and clinical spectrum of gastroesophageal reflux: a population-based study in Olmsted County, Minnesota. Gastroenterology. 1997;112(5):1448-56.
• Flegal KM, Carroll MD, Ogden CL, Johnson CL. Prevalence and trends in obesity among US adults, 1999-2000. Jama. 2002;288(14):1723-7.
• Kitapcioglu G, Caymaz-Bor C, Gilbert RJ. Gastroesophageal reflux disease in a low-income region in Turkey. The American journal of gastroenterology. 2005;100(4):759.
• Turan S, Poyraz C, Ozdemir A. Binge Eating Disorder. Psikiyatride Guncel Yaklasimlar. 2015;7:419-35.
• Association AP. Diagnostic and statistical manual of mental disorders (DSM-5®): American Psychiatric Pub; 2013.
• Hudson JI, Hiripi E, Pope Jr HG, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biological psychiatry. 2007;61(3):348-58.
• Field AE, Sonneville KR, Micali N, Crosby RD, Swanson SA, Laird NM, et al. Prospective association of common eating disorders and adverse outcomes. Pediatrics. 2012;130(2):e289-e95.
• Fairburn CG, Cooper Z, Doll HA, Norman P, O'Connor M. The natural course of bulimia nervosa and binge eating disorder in young women. Archives of General psychiatry. 2000;57(7):659-65.
• Sonneville KR, Horton NJ, Micali N, Crosby RD, Swanson SA, Solmi F, et al. Longitudinal associations between binge eating and overeating and adverse outcomes among adolescents and young adults: does loss of control matter? JAMA pediatrics. 2013;167(2):149-55.
• Olguin P, Fuentes M, Gabler G, Guerdjikova AI, Keck PE, McElroy SL. Medical comorbidity of binge eating disorder. Eating and Weight Disorders-Studies on Anorexia, Bulimia and Obesity. 2017;22(1):13-26.
• Group CGS. Value of reflux diagnostic questionnaire in the diagnosis of gastroesophageal reflux disease. Chinese Journal of Digestive Diseases. 2004;5(2):51-5.
• Jones R, Junghard O, Dent J, Vakil N, Halling K, Wernersson B, et al. Development of the GerdQ, a tool for the diagnosis and management of gastro‐oesophageal reflux disease in primary care. Alimentary pharmacology & therapeutics. 2009;30(10):1030-8.
• Yuan L-Z, Yi P, Wang G-S, Tan S-Y, Huang G-M, Qi L-Z, et al. Lifestyle intervention for gastroesophageal reflux disease: a national multicenter survey of lifestyle factor effects on gastroesophageal reflux disease in China. Therapeutic advances in gastroenterology. 2019;12:1756284819877788.
• Johnson LF, DeMeester TR. Development of the 24-hour intraesophageal pH monitoring composite scoring system. Journal of clinical gastroenterology. 1986;8:52-8.
• Buttar NS, Falk GW, editors. Pathogenesis of gastroesophageal reflux and Barrett esophagus. Mayo Clinic Proceedings; 2001: Elsevier.
• Friedenberg FK, Xanthopoulos M, Foster GD, Richter JE. The association between gastroesophageal reflux disease and obesity. The American journal of gastroenterology. 2008;103(8):2111.
• Moki F, Kusano M, Mizuide M, Shimoyama Y, Kawamura O, Takagi H, et al. Association between reflux oesophagitis and features of the metabolic syndrome in Japan. Alimentary pharmacology & therapeutics. 2007;26(7):1069-75.
• Shepherd KL, James AL, Musk AW, Hunter ML, Hillman DR, Eastwood PR. Gastro‐oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea. Journal of sleep research. 2011;20(1pt2):241-9.
• Dore MP, Maragkoudakis E, Fraley K, Pedroni A, Tadeu V, Realdi G, et al. Diet, lifestyle and gender in gastro-esophageal reflux disease. Digestive diseases and sciences. 2008;53(8):2027-32.
• Labenz J, Kulig M, Leodolter A, Vieth M. Risk factors for erosive esophagitis: a multivariate analysis based on the ProGERD study initiative. The American journal of gastroenterology. 2004;99(9):1652.
• Nozu T, Komiyama H. Clinical characteristics of asymptomatic esophagitis. Journal of gastroenterology. 2008;43(1):27-31.
• Bayrakci B, Kasap E, Kitapçioğlu G, Bor S. Low prevalence of erosive esophagitis and Barrett esophagus in a tertiary referral center in Turkey. The Turkish journal of gastroenterology: the official journal of Turkish Society of Gastroenterology. 2008;19(3):145-51.
• Veugelers P, Porter G, Guernsey D, Casson A. Obesity and lifestyle risk factors for gastroesophageal reflux disease, Barrett esophagus and esophageal adenocarcinoma. Diseases of the Esophagus. 2006;19(5):321-8.
• Shaheen N, Ransohoff DF. Gastroesophageal reflux, Barrett esophagus, and esophageal cancer: scientific review. Jama. 2002;287(15):1972-81.
• Ayazi S, Tamhankar A, DeMeester SR, Zehetner J, Wu C, Lipham JC, et al. The impact of gastric distension on the lower esophageal sphincter and its exposure to acid gastric juice. Annals of surgery. 2010;252(1):57-62.
• Newberry C, Lynch K. The role of diet in the development and management of gastroesophageal reflux disease: why we feel the burn. Journal of thoracic disease. 2019;11(Suppl 12):S1594.