Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi

Zeliha Esin Çelik; Güler Yavaş; Burcu Sanal Yılmaz; Tolgay Tuyan İlhan; Çağdaş Yavaş; Özlem Ata; Çetin Çelik

TR EN

Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi

Abstract

Amaç: Çalışmamızda endometriyum adenokarsinomu tanılı hastalarda preoperatif tam kan sayımı parametrelerinin çeşitli klinikopatolojik prognostik parametrelerle ve sağkalım ile ilişkisi olup olmadığını değerlendirmeyi amaçladık.Gereç ve Yöntem: Ocak 2011-Aralık 2014 tarihleri arasında fakültemizde opere edilen ve endometrial adenokarsinom tanısı alan 144 hasta çalışmaya dahil edilmiştir. Hemogram parametrelerinden absolü beyaz küre sayısı BK , absolü platelet sayısı Plt hematokrit Hct , hemoglobin Hb değerleri yanı sıra absolü nötrofil sayısının absolü lenfosit sayısına bölümü olan NLR, absolü platelet sayısının absolü lenfosit sayısına bölümü olan PLR ve absolü monosit sayısının absolü lenfosit sayısına bölümü olan MLR oranlarının; tümör çapı, tümör derecesi, FIGO evresi, serviks invazyonu, pozitif lenf nodu sayısı, lenf nodunda ekstrakapsüler yayılım, lenfovasküler invazyon LVİ , myometrial invazyon derinliği gibi prognostik parametreler ve hastalıksız ve genel sağkalım süreleri ile olan ilişkisi istatistiksel metodlarla araştırılmıştır.Bulgular: Derece 3 tümöre sahip hastalarda BK sayısının derece 1 tümörlü hastalara göre anlamlı derecede düşük olduğu görüldü p=0.04 . LVİ olan olgularda PLR p=0.018 ve MLR p=0.028 LVİ olmayan hastalara göre daha düşük idi. Düşük evre olgularda evre I-II PLR, yüksek evreli olgulara göre evre II-III daha düşük tespit edildi p=0.03 . Tedavi öncesi bakılan tam kan parametreleri ile tümör çapı, serviks invazyonu, pozitif lenf nodu sayısı, lenf nodunda ekstrakapsüler yayılım, myometrial invazyon derinliği, hastalıksız sağkalım ve genel sağkalım arasında anlamlı bir ilişki saptanmadı p>0.05 .Sonuç: Endometriyum kanserinde tedavi öncesi tam kan sayımı parametrelerinin bir arada kullanılması, hastalığın prognozu ile ilgili fikir verebilir. Çalışmamızın sonuçlarının daha uzun takip süresine ve daha geniş olgu sayısına sahip çalışmalarla desteklenmesi gereklidir

Keywords

Endometrium kanseri, prognoz, nötrofil lenfosit oranı, platelet lenfosit oranı, monosit lenfosit oranı

Abstract

Objective: To evaluate the relation of preoperative complete blood count CBC parameters with prognostic parameters and survival in patients with endometrial cancer. Materials and Methods: One hundred and forty four patients operated at our faculty and diagnosed as endometrial adenocarcinoma between January 2011 and December 2014 were included the present study. The relation of the CBC parameters including white blood cell count WBC , platelet count Plt , hematocrit Hct , hemoglobin Hb , neutrophil/lymphocyte ratio NLR , platelet/lymphocyte ratio PLR , monocyte/lymphocyte ratio MLR with prognostic parameters such as tumor size, tumor grade, International Federation of Gynecologists and Obstetricians FIGO stage, cervical involvement, positive lymph nodes, extracapsular extension of lymph nodes, lympho-vascular invasion LVI , myometrial invasion depth and disease free survival and overall survival investigated statistically.Results: Patients with grade III tumors had higher WBC count than those with grade I tumors p=0,04 . PLR and MLR was significantly lower in patients with LVI than those with no invasion p=0,018 and p=0,028 respectively . FIGO stage I-II patients had lower PLR than stage III-IV patients p=0.03 . No relation was determined between pretreatment CBC parameters and tumor size, cervical involvement, positive lymph nodes, extracapsular extension of lymph nodes, myometrial invasion depth and disease free survival and overall survival p>0.05 .Conclusion: Using of multiple pretreatment CBC parameters may provide information about the outcome of endometrial cancer patients. Further studies with larger series and long term follow-up are needed to support the results of the present study

Keywords

Endometrial cancer, prognosis, neutrophil lymphocyte ratio, platelet lymphocyte ratio, monocyte lymphocyte ratio

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Details

Primary Language

Turkish

Subjects

-

Journal Section

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Authors

Zeliha Esin Çelik This is me

Güler Yavaş This is me

Burcu Sanal Yılmaz This is me

Tolgay Tuyan İlhan This is me

Çağdaş Yavaş This is me

Özlem Ata This is me

Çetin Çelik This is me

Publication Date

March 1, 2018

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-

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Year 2018 Volume: 28 Number: 2

IZ

https://izlik.org/JA38XR74DD

APA

Çelik, Z. E., Yavaş, G., Yılmaz, B. S., İlhan, T. T., Yavaş, Ç., Ata, Ö., & Çelik, Ç. (2018). Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi. Genel Tıp Dergisi, 28(2), 63-68. https://izlik.org/JA38XR74DD

AMA

1.Çelik ZE, Yavaş G, Yılmaz BS, et al. Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi. Genel Tıp Derg. 2018;28(2):63-68. https://izlik.org/JA38XR74DD

Chicago

Çelik, Zeliha Esin, Güler Yavaş, Burcu Sanal Yılmaz, et al. 2018. “Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler Ve Sağkalımla İlişkisi”. Genel Tıp Dergisi 28 (2): 63-68. https://izlik.org/JA38XR74DD.

EndNote

Çelik ZE, Yavaş G, Yılmaz BS, İlhan TT, Yavaş Ç, Ata Ö, Çelik Ç (March 1, 2018) Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi. Genel Tıp Dergisi 28 2 63–68.

IEEE

[1]Z. E. Çelik et al., “Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi”, Genel Tıp Derg, vol. 28, no. 2, pp. 63–68, Mar. 2018, [Online]. Available: https://izlik.org/JA38XR74DD

ISNAD

Çelik, Zeliha Esin - Yavaş, Güler - Yılmaz, Burcu Sanal - İlhan, Tolgay Tuyan - Yavaş, Çağdaş - Ata, Özlem - Çelik, Çetin. “Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler Ve Sağkalımla İlişkisi”. Genel Tıp Dergisi 28/2 (March 1, 2018): 63-68. https://izlik.org/JA38XR74DD.

JAMA

1.Çelik ZE, Yavaş G, Yılmaz BS, İlhan TT, Yavaş Ç, Ata Ö, Çelik Ç. Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi. Genel Tıp Derg. 2018;28:63–68.

MLA

Çelik, Zeliha Esin, et al. “Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler Ve Sağkalımla İlişkisi”. Genel Tıp Dergisi, vol. 28, no. 2, Mar. 2018, pp. 63-68, https://izlik.org/JA38XR74DD.

Vancouver

1.Zeliha Esin Çelik, Güler Yavaş, Burcu Sanal Yılmaz, Tolgay Tuyan İlhan, Çağdaş Yavaş, Özlem Ata, Çetin Çelik. Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi. Genel Tıp Derg [Internet]. 2018 Mar. 1;28(2):63-8. Available from: https://izlik.org/JA38XR74DD

The Journal of General Medicine is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY NC).

Endometrium Kanserli Hastalarda Preoperatif Tam Kan Sayımının Prognostik Parametreler ve Sağkalımla İlişkisi

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