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Kronik Lenfositik Tiroiditli Olgular ve Normal Populasyonda D Vitamini Düzeylerinin Karşılaştırılması ve Otoimmünite Üzerindeki Rolü

Year 2022, , 386 - 389, 31.08.2022
https://doi.org/10.54005/geneltip.1084434

Abstract

Amaç
D vitamini eksikliğinin otoimmün hastalıklar, inflamatuar bağırsak hastalığı, romatoid artrit, multipl skleroz, diyabet, birçok kanser türü ve kalp hastalıklarının oluşumunda rolü olduğu bilinmektedir. Bu çalışma, D vitamininin Hashimoto tiroiditindeki rolünü göstermek için yapılmıştır.
Gereç ve Yöntem
Bu kesitsel çalışmaya 16-50 yaş aralığında İzmir Bozyaka Eğitim ve Araştırma Hastanesi endokrinoloji polikliniğine başvuran ultrasonografik olarak kronik tiroidit ile uyumlu ,serolojik olarak antikor pozitif (anti T, anti M) ,ötiorid ,beden kütle indeksi (BKİ) < 30 olan menapoza girmemiş , herhangi başka ek bir hastalığı ve kronik ilaç kullanımı olmayan 40 Hashimoto tiroditli kadın hasta ile yine İzmir Bozyaka Eğitim ve Araşatırma Hastanesi dahiliye veya endokrinoloji polikliniklerine başvurmuş olan 16-50 yaş aralığında beden kütle indeksi (BKİ) <30 olan 40 sağlıklı, tiiroid antikorları negatif kadın hasta alındı. Obezitenin D vitamini-hormonu ile negatif ilişkisi daha önceden yapılan çalışmalarda gösterilmiş olduğundan çalışmamıza beden kütle indeksi (BKİ) >30 olan Hashimoto tiroiditli veya sağlıklı gönüllüler alınmamıştır.

Bulgular

İki grup yaş, vücut kitle indeksi, t3, t4, TSH, Anti M, Anti T ve D vitamini açısından karşılaştırıldığında iki grup arasında istatistiksel olarak anlamlı fark bulunamadı. Spearman korelasyon testi sonucunda D vitamini düzeyi ile diğer herhangi bir parametre arasında istatistiksel olarak pozitif veya negatif korelasyon bulunamadı (p>0.05).

Sonuç

Sonuç olarak bu çalışmada Hashimoto tiroiditi ile D vitamini eksikliği arasında bir ilişki bulunabileceği görüldü. Kontrol grubunda da D vitamini düzeylerinin eksik bulunmuş olması nedeniyle bu çalısmadaki bulgulara bakarak Hashimoto tiroiditi ile D vitamini eksikliğinin korelasyonu ile ilgili net bir yorum getirilemez. Bizim çalışmamızın otoimmun tiroid hastalıkları ile D vitamini eksikliği arasındaki ilişkiyi daha kapsamlı arastıracak çalışmalar için yardımcı olacağını ummaktayız.

References

  • 1) Jameson JL, Weetman AP.. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, LongoDL, Jameson JL, editors. translation editor: Sağlıker Y. Harrison Principles of Internaal Medicine (15. Edition). Istanbul: Nobel ; 2004. S.2060-2075
  • 2) Hollick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancer and cardiovascular disease. Am J Clin Nutr 2004; 80 (6suppl): S1678- 88.
  • 3) Holick MF. The Vitamin D epidemic and its health consequences. J Nutr 2005; 135:2739- 48.
  • 4) Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 2005; 98: 1024- 7.
  • 5) Mathieu C, Van Etten E, Decallonne B, Guilietti A, Gyseman C, Bouillon R et al. Vitamin D and 1,25 dihydroxyvitamin D3 as modulators in immun system. J Steroid Biochem Mol Biol 2004; 89- 90: 449- 52.
  • 6) Mathieu C. Adorini L. The coming age of 1,25 dihydroxyvitamin D3 analogs as immunomodulatory agents. Trends Mol Med 2002; 8: 174- 9.
  • 7) İlicin G, Unal S, Biberoğlu K, Akalın S, Suleymanlar G, internal medicine volume 2, second edition Ankara: Gunes Kitapevi ISBN 975- 8531- 78- 6. S:2217- 2219.
  • 8) Lin WY, Wan L, Tsai CH, Chen RH, Lee CC, Tsai FC. Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis in Chinese patients in Taiwan. J Clin Lab Anal 2006; 20: 109- 12.
  • 9) Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int. 2006;17:1133-1140.
  • 10) Chistiakov DA. Immunogenetics of Hashimoto’s thyroiditis. J Autoimmune Dis 2005; 2: 1.
  • 11) Fournier C, Gepner P, Sadouk M. In vivo beneficial effects of cyclosporine A and 1,25- dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54: 53- 63.
  • 12) Stefanic M, Papic S, Suver M. Association of vitamin D gene 3’- variants with Hashimoto’s thyroiditis in the Croatian population. Int J Immunogenet 2008; 35: 125- 31.
  • 13) Youshiyuki Ban, Matsuo Taniyama, Yoshio Ban. Vitamin D receptor gene polymorphism in Hashimoto’s thyroiditis. Thyroid 2002; 11(6): 607- 608.
  • 14) Engelsen O, Brustad M, Aksnes L. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005; 81: 1287– 9.
  • 15) Dawodu A, Absood G, Patel M, Agarwal M, Ezimokhai M, Abdulrazzaq Y, et al Biosocial factors affecting vitamin D status of women of childbearing age in the United Arab Emirates. J Bios Sci 1998; 30: 431- 7.
  • 16) Nujen Çolak Bozkurt,; Basak Karbek,,et al the association between severity of vitamin d deficiency and Hashimoto’s thyroiditis DOI:10.4158/EP12376.OR
  • 17) Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011;8:243-247.
  • 18) Goswami R, Marwaha RK, Gupta N, et al. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr. 2009;102:382-386.
  • 19) Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003; 348:2646-2455.
  • 20) Baeke F, Korf H, Overbergh L, et al. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. J Steroid Biochem Mol Biol. 2010;121:221-227.
  • 21) Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25- dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717-1720.

Comparison of Vitamin D Levels in Patients with Chronic Lymphocytic Thyroiditis and the Normal Population, and Role of Vitamin D on Autoimmunity

Year 2022, , 386 - 389, 31.08.2022
https://doi.org/10.54005/geneltip.1084434

Abstract

Purpose
It is known that vitamin D deficiency has a role in the formation of autoimmune diseases, inflammatory bowel disease, rheumatoid arthritis, multiple sclerosis, diabetes, many types of cancer and heart diseases. This study was conducted to demonstrate the role of vitamin D in Hashimoto's thyroiditis.
Methods
In this cross-sectional study, the patients who applied to Izmir Bozyaka Training and Research Hospital endocrinology outpatient clinic between the ages of 16 and 50 were evaluated with ultrasonographically consistent with chronic thyroiditis, serologically antibody positive (anti T, anti M), euthyroid, body mass index (BMI) <30, 40 women with Hashimoto's thyroiditis who did not enter menopause, did not have any other additional disease and did not use chronic medication, and 16-50 women who applied to the internal medicine or endocrinology polyclinics of Izmir Bozyaka Training and Research Hospital 40 healthy female patients with a body mass index (BMI) <30 years and negative for thyroid antibodies were recruited.
Results
When the two groups were compared in terms of age, body mass index, t3, t4, TSH, Anti M, Anti T and vitamin D, no statistically significant difference was found between the two groups. As a result of the Spearman correlation test, no statistically positive or negative correlation was found between vitamin D level and any other parameter (p >0.05).
Conclusion
In conclusion, in this study, it was seen that there may be a relationship between Hashimoto's thyroiditis and vitamin D deficiency. Since vitamin D levels were found to be deficient in the control group, a clear interpretation cannot be made regarding the correlation of Hashimoto's thyroiditis and vitamin D deficiency based on the findings of this study. We hope that our study will be helpful for further studies that will investigate the relationship between autoimmune thyroid diseases and vitamin D deficiency.

References

  • 1) Jameson JL, Weetman AP.. In: Braunwald E, Fauci AS, Kasper DL, Hauser SL, LongoDL, Jameson JL, editors. translation editor: Sağlıker Y. Harrison Principles of Internaal Medicine (15. Edition). Istanbul: Nobel ; 2004. S.2060-2075
  • 2) Hollick MF. Sunlight and vitamin D for bone health and prevention of autoimmune diseases, cancer and cardiovascular disease. Am J Clin Nutr 2004; 80 (6suppl): S1678- 88.
  • 3) Holick MF. The Vitamin D epidemic and its health consequences. J Nutr 2005; 135:2739- 48.
  • 4) Holick MF. Vitamin D: important for prevention of osteoporosis, cardiovascular heart disease, type 1 diabetes, autoimmune diseases, and some cancers. South Med J 2005; 98: 1024- 7.
  • 5) Mathieu C, Van Etten E, Decallonne B, Guilietti A, Gyseman C, Bouillon R et al. Vitamin D and 1,25 dihydroxyvitamin D3 as modulators in immun system. J Steroid Biochem Mol Biol 2004; 89- 90: 449- 52.
  • 6) Mathieu C. Adorini L. The coming age of 1,25 dihydroxyvitamin D3 analogs as immunomodulatory agents. Trends Mol Med 2002; 8: 174- 9.
  • 7) İlicin G, Unal S, Biberoğlu K, Akalın S, Suleymanlar G, internal medicine volume 2, second edition Ankara: Gunes Kitapevi ISBN 975- 8531- 78- 6. S:2217- 2219.
  • 8) Lin WY, Wan L, Tsai CH, Chen RH, Lee CC, Tsai FC. Vitamin D receptor gene polymorphisms are associated with risk of Hashimoto’s thyroiditis in Chinese patients in Taiwan. J Clin Lab Anal 2006; 20: 109- 12.
  • 9) Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int. 2006;17:1133-1140.
  • 10) Chistiakov DA. Immunogenetics of Hashimoto’s thyroiditis. J Autoimmune Dis 2005; 2: 1.
  • 11) Fournier C, Gepner P, Sadouk M. In vivo beneficial effects of cyclosporine A and 1,25- dihydroxyvitamin D3 on the induction of experimental autoimmune thyroiditis. Clin Immunol Immunopathol 1990; 54: 53- 63.
  • 12) Stefanic M, Papic S, Suver M. Association of vitamin D gene 3’- variants with Hashimoto’s thyroiditis in the Croatian population. Int J Immunogenet 2008; 35: 125- 31.
  • 13) Youshiyuki Ban, Matsuo Taniyama, Yoshio Ban. Vitamin D receptor gene polymorphism in Hashimoto’s thyroiditis. Thyroid 2002; 11(6): 607- 608.
  • 14) Engelsen O, Brustad M, Aksnes L. Daily duration of vitamin D synthesis in human skin with relation to latitude, total ozone, altitude, ground cover, aerosols and cloud thickness. Photochem Photobiol 2005; 81: 1287– 9.
  • 15) Dawodu A, Absood G, Patel M, Agarwal M, Ezimokhai M, Abdulrazzaq Y, et al Biosocial factors affecting vitamin D status of women of childbearing age in the United Arab Emirates. J Bios Sci 1998; 30: 431- 7.
  • 16) Nujen Çolak Bozkurt,; Basak Karbek,,et al the association between severity of vitamin d deficiency and Hashimoto’s thyroiditis DOI:10.4158/EP12376.OR
  • 17) Kivity S, Agmon-Levin N, Zisappl M, et al. Vitamin D and autoimmune thyroid diseases. Cell Mol Immunol. 2011;8:243-247.
  • 18) Goswami R, Marwaha RK, Gupta N, et al. Prevalence of vitamin D deficiency and its relationship with thyroid autoimmunity in Asian Indians: a community-based survey. Br J Nutr. 2009;102:382-386.
  • 19) Pearce EN, Farwell AP, Braverman LE. Thyroiditis. N Engl J Med. 2003; 348:2646-2455.
  • 20) Baeke F, Korf H, Overbergh L, et al. Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system. J Steroid Biochem Mol Biol. 2010;121:221-227.
  • 21) Cantorna MT, Zhu Y, Froicu M, Wittke A. Vitamin D status, 1,25- dihydroxyvitamin D3, and the immune system. Am J Clin Nutr. 2004;80:1717-1720.
There are 21 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Article
Authors

Serkan Yıldırım 0000-0001-7998-1558

Publication Date August 31, 2022
Submission Date March 8, 2022
Published in Issue Year 2022

Cite

Vancouver Yıldırım S. Comparison of Vitamin D Levels in Patients with Chronic Lymphocytic Thyroiditis and the Normal Population, and Role of Vitamin D on Autoimmunity. Genel Tıp Derg. 2022;32(4):386-9.