Comparison of the Effects of Alcohol and Phenol Used for Celiac Neurolysis with Endoscopic Ultrasound in Patients with Pancreas Cancer: Retrospective Analysis

Uğur Özgürbüz; Birzat Emre Gölboyu

doi:10.54005/geneltip.1167315

Clinical Research

PANKREAS KANSERİ TANILI HASTALARDA ENDOSKOPİK ULTRASON EŞLİĞİNDE ÇÖLYAK NÖROLİZ AĞRI TEDAVİSİ İÇİN KULLANILAN ALKOL VE FENOLÜN ETKİLERİNİN KARŞILATIRILMASI: RETROSPEKTİF ANALİZ

Year 2022, , 746 - 750, 31.12.2022

Uğur Özgürbüz , Birzat Emre Gölboyu

https://doi.org/10.54005/geneltip.1167315

Abstract

Amaç: Çalışmada amacımız EUS rehberliğinde uygulanan çölyak pleksus nöroliz işleminde kullanılan etanol ve fenolün ağrı skorları ve komplikasyonlar üzerine etkinliklerini karşılaştırmaktır.
Gereç Yöntem: Ocak 2009 ve Haziran 2022 tarihleri arasında endoskopi biriminde sedasyon altında EUS (endoskopik ultrasonografi) rehberliğinde çöliyak nöroliz uygulanan 28 hasta dahil edildi. Pankreas kanseri tanılı hastaların ağrı tedavisi için uygulanan EUS rehberliğinde çölyak nöroliz girişiminin verilerini retrospektif olarak inceledik
Bulgular: Alkol grubundaki hastaların ağrı skorları daha düşük saptanmıştır.
Sonuç: Alkol ve fenol bazlı nörolitik teknikler karşılaştırıldığında alkol grubunda daha iyi analjezik etki elde edilmiştir

Keywords

alkol, çölyak nöroliz, endoskopik ultrason, fenol

References

1. Schmidt-Hansen M, Bennett MI, Arnold S, Bromham N, Hilgart JS. oxycodone for cancer-related pain _ Cochrane Database System Rev [Internet]. 2017 Aug 22 [ cited 2022 Jul 12];8(8). available from : https://pubmed.ncbi.nlm.nih.gov/28829910/
2. Kanno Y, Koshita S, Masu K, Ogawa T, Kusunose H, Murabayashi T, et al. Efficacy of EUS- guided celiac plexus neurolysis compared with medication alone for unresectable pancreatic cancer in the oxycodone / fentanyl era : a prospective randomized control study _ gastrointestinal Endoscopy . 2020;92(1):120–30.
3. Asif AA, Walayat SK, Bechtold ML, Revanur V, Puli SR. EUS guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta- analysis and systematic review . vol . 11, Journal of Community hospital internal medicine Perspectives . 2021.p. 536–42.
4. Teoh AYB, Dhir V, Kida M, Yasuda I, Jin ZD, Seo DW, et al. consensus guidelines on the optimal management in interventional EUS procedures : results from the Asian EUS group RAND/UCLA expert panel. Gout [Internet]. 2018 [ cited 2022 Jul 12];67(7):1209–28. available from : https://pubmed.ncbi.nlm.nih.gov/29463614/
5. Ishiwatari H, Hayashi T, Yoshida M, Ono M, Masuko H, Sato T, et al. Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients : A pilot study . World Journal of Gastroenterology . 2014;20(30):10512–7.
6. Haaga JR, Kori SH, Eastwood DW, Borkowski GP. improved technique for CT - guided celiac ganglia block . AJR Am J Roentgenol [Internet]. 1984 [ cited 2022 Jul 13];142(6):1201–4. available from : https://pubmed.ncbi.nlm.nih.gov/6609609/
7. Kappis M. Erfahrungen myth localanasthesie bei bauchoperation _ verb dtsch ges chir . 1914;43:87 –9.
8. Mercadante S, Nicosia F. Celiac plexus block : a reappraisal . Reg Anesth pain Med [Internet]. 1998 [ cited 2022 Jul 13];23(1):37–48. available from : https://pubmed.ncbi.nlm.nih.gov/9552777/
9. Leblanc JK, Al- Haddad M, McHenry L, Sherman S, Juan M, McGreevy K, et al. A prospective , randomized study of EUS- guided celiac plexus neurolysis for pancreatic cancer : one injection or two ? gastrointestinal Endosc [Internet]. 2011 Dec [ cited 2022 Jul 13];74(6):1300–7. available from : https://pubmed.ncbi.nlm.nih.gov/22000795/
10. Téllez-Ávila FI, Romano-Munive AF, de Jesús Herrera-Esquivel J, Ramírez-Luna MA. Central is as effective as bilateral endoscopic ultrasound-guided celiac plexus neurolysis in patients with unresectable pancreatic cancer . endosc ultrasound [Internet]. 2013 [ cited 2022 Jul 13];2(3):153–6. available from : https://pubmed.ncbi.nlm.nih.gov/24949384/
11. de Cicco M, Matovic M, Bortolussi R, Coran F, Fantin D, Fabiani F, et al. celiac plexus block : injectate spread and pain relief in patients with regional anatomic distortion _ Anesthesiology [Internet]. 2001 [ cited 2022 Jul 13];94(4):561–5. available from : https://pubmed.ncbi.nlm.nih.gov/11379673/
12. Nagels W, Pease N, Bekkering G, Cools F, Dobbels P. Celiac plexus neurolysis for abdominal cancer pain : a systematic review . pain Med [Internet]. 2013 [ cited 2022 Jul 13];14(8):1140–63. available from : https://pubmed.ncbi.nlm.nih.gov/23802777/
13. Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, et al. EUS guided broad plexus neurolysis over the superior mesenteric artery using a 25-gauge needle . Am J Gastroenterol [Internet]. 2010 Dec [ cited 2022 Jul 13];105(12):2599–606. available from : https://pubmed.ncbi.nlm.nih.gov/20823834/
14. Zhang CL, Zhang TJ, Guo YN, Yang LQ, He MW, Shi JZ, et al. Effect of neurolytic celiac plexus block guided by computerized tomography on pancreatic cancer pain _ dig External Sci [Internet]. 2008 Mar [ cited 2022 Jul 13];53(3):856–60. available from : https://pubmed.ncbi.nlm.nih.gov/17676392/
15. Wong GY, Schroeder DR, Carns PE, Wilson JL, Martin DP, Kinney MO, et al. Effect of neurolytic celiac plexus block on pain relief , quality of life, and survival in patients with unresectable pancreatic cancer : a randomized controlled trial . JAMA [Internet]. 2004 Mar 3 [ cited 2022 Jul 13];291(9):1092–9. available from : https://pubmed.ncbi.nlm.nih.gov/14996778/
16. Kawamata M, Ishitani K, Ishikawa K, Sasaki H, Ota K, Omote K, et al. Comparison between celiac plexus block and morphine treatment on quality of life in patients with pancreatic cancer pain _ Pain [Internet]. 1996 [ cited 2022 Jul 13];64(3):597–602. available from : https://pubmed.ncbi.nlm.nih.gov/8783327/
17. Bang JY, Sutton B, Hawes RH, Varadarajulu S. EUS- guided celiac ganglion radiofrequency ablation versus celiac plexus neurolysis for palliation of pain in pancreatic cancer : a randomized controlled trial ( with videos ). gastrointestinal Endoscopy [Internet]. 2019;89(1):58-66.e3. available from : https://doi.org/10.1016/j.gie.2018.08.005
18. Ishiwatari H, Hayashi T, Yoshida M, Ono M, Sato T, Miyanishi K, et al. EUS guided celiac plexus neurolysis by using highly viscous phenol-glycerol as a neurolytic agent ( with video). gastrointestinal Endoscopy [Internet]. 2015;81(2):479–83. available from : http://dx.doi.org/10.1016/j.gie.2014.10.031
19. O'Toole TM, Schmulewitz N. Complication rates of EUS- guided celiac plexus blockade and neurolysis : results of a large case series . Endoscopy [Internet]. 2009 [ cited 2022 Jul 13];41(7):593–7. available from : https://pubmed.ncbi.nlm.nih.gov/19588286/
20. Alvarez-Sánchez MV, Jenssen C, Faiss S, Napoléon B. Interventional endoscopic ultrasonography : an overview of safety and costs . Surg Endosc [Internet]. 2014 [ cited 2022 Jul 13];28(3):712–34. available from : https://pubmed.ncbi.nlm.nih.gov/24196551/
21. Sahai A v., Lemelin V, Lam E, Paquin SC. Central vs. bilateral endoscopic ultrasound-guided celiac plexus block or neurolysis : a comparative study of short term effect . Am J Gastroenterol [Internet]. 2009 Feb [ cited 2022 Jul 13];104(2):326–9. available from : https://pubmed.ncbi.nlm.nih.gov/19174816/
22. Minaga K, Kitano M, Imai H, Miyata T, Kudo M. Acute spinal cord infarction after EUS- guided celiac plexus neurolysis _ gastrointestinal Endosc [Internet]. 2016 May 1 [ cited 2022 Jul 13];83(5):1039–40. available from : https://pubmed.ncbi.nlm.nih.gov/26551729/

Comparison of the Effects of Alcohol and Phenol Used for Celiac Neurolysis with Endoscopic Ultrasound in Patients with Pancreas Cancer: Retrospective Analysis

Year 2022, , 746 - 750, 31.12.2022

Uğur Özgürbüz , Birzat Emre Gölboyu

https://doi.org/10.54005/geneltip.1167315

Abstract

Objective: In this study we aimed to compare the efficacy of ethanol and phenol used in the EUS-guided celiac plexus neurolysis procedure on pain scores and complications.
Material and Methods: Between January 2009 and June 2022, 28 patients who underwent celiac neurolysis underwent sedation via EUS (endoscopic ultrasonography) guidance in the endoscopy unit were included. We retrospectively analyzed the data of the EUS-guided celiac neurolysis procedures for pain management of patients with pancreatic cancer.
Results: Patients in the alcohol group had lower pain scores.
Conclusion: When alcohol and phenol-based neurolytic techniques were compared, better analgesic effect was obtained in the alcohol group.

Keywords

alcohol, celiac neurolysis, endoscopic ultrasound, phenol

References

1. Schmidt-Hansen M, Bennett MI, Arnold S, Bromham N, Hilgart JS. oxycodone for cancer-related pain _ Cochrane Database System Rev [Internet]. 2017 Aug 22 [ cited 2022 Jul 12];8(8). available from : https://pubmed.ncbi.nlm.nih.gov/28829910/
2. Kanno Y, Koshita S, Masu K, Ogawa T, Kusunose H, Murabayashi T, et al. Efficacy of EUS- guided celiac plexus neurolysis compared with medication alone for unresectable pancreatic cancer in the oxycodone / fentanyl era : a prospective randomized control study _ gastrointestinal Endoscopy . 2020;92(1):120–30.
3. Asif AA, Walayat SK, Bechtold ML, Revanur V, Puli SR. EUS guided celiac plexus neurolysis for pain in pancreatic cancer patients – a meta- analysis and systematic review . vol . 11, Journal of Community hospital internal medicine Perspectives . 2021.p. 536–42.
4. Teoh AYB, Dhir V, Kida M, Yasuda I, Jin ZD, Seo DW, et al. consensus guidelines on the optimal management in interventional EUS procedures : results from the Asian EUS group RAND/UCLA expert panel. Gout [Internet]. 2018 [ cited 2022 Jul 12];67(7):1209–28. available from : https://pubmed.ncbi.nlm.nih.gov/29463614/
5. Ishiwatari H, Hayashi T, Yoshida M, Ono M, Masuko H, Sato T, et al. Phenol-based endoscopic ultrasound-guided celiac plexus neurolysis for East Asian alcohol-intolerant upper gastrointestinal cancer patients : A pilot study . World Journal of Gastroenterology . 2014;20(30):10512–7.
6. Haaga JR, Kori SH, Eastwood DW, Borkowski GP. improved technique for CT - guided celiac ganglia block . AJR Am J Roentgenol [Internet]. 1984 [ cited 2022 Jul 13];142(6):1201–4. available from : https://pubmed.ncbi.nlm.nih.gov/6609609/
7. Kappis M. Erfahrungen myth localanasthesie bei bauchoperation _ verb dtsch ges chir . 1914;43:87 –9.
8. Mercadante S, Nicosia F. Celiac plexus block : a reappraisal . Reg Anesth pain Med [Internet]. 1998 [ cited 2022 Jul 13];23(1):37–48. available from : https://pubmed.ncbi.nlm.nih.gov/9552777/
9. Leblanc JK, Al- Haddad M, McHenry L, Sherman S, Juan M, McGreevy K, et al. A prospective , randomized study of EUS- guided celiac plexus neurolysis for pancreatic cancer : one injection or two ? gastrointestinal Endosc [Internet]. 2011 Dec [ cited 2022 Jul 13];74(6):1300–7. available from : https://pubmed.ncbi.nlm.nih.gov/22000795/
10. Téllez-Ávila FI, Romano-Munive AF, de Jesús Herrera-Esquivel J, Ramírez-Luna MA. Central is as effective as bilateral endoscopic ultrasound-guided celiac plexus neurolysis in patients with unresectable pancreatic cancer . endosc ultrasound [Internet]. 2013 [ cited 2022 Jul 13];2(3):153–6. available from : https://pubmed.ncbi.nlm.nih.gov/24949384/
11. de Cicco M, Matovic M, Bortolussi R, Coran F, Fantin D, Fabiani F, et al. celiac plexus block : injectate spread and pain relief in patients with regional anatomic distortion _ Anesthesiology [Internet]. 2001 [ cited 2022 Jul 13];94(4):561–5. available from : https://pubmed.ncbi.nlm.nih.gov/11379673/
12. Nagels W, Pease N, Bekkering G, Cools F, Dobbels P. Celiac plexus neurolysis for abdominal cancer pain : a systematic review . pain Med [Internet]. 2013 [ cited 2022 Jul 13];14(8):1140–63. available from : https://pubmed.ncbi.nlm.nih.gov/23802777/
13. Sakamoto H, Kitano M, Kamata K, Komaki T, Imai H, Chikugo T, et al. EUS guided broad plexus neurolysis over the superior mesenteric artery using a 25-gauge needle . Am J Gastroenterol [Internet]. 2010 Dec [ cited 2022 Jul 13];105(12):2599–606. available from : https://pubmed.ncbi.nlm.nih.gov/20823834/
14. Zhang CL, Zhang TJ, Guo YN, Yang LQ, He MW, Shi JZ, et al. Effect of neurolytic celiac plexus block guided by computerized tomography on pancreatic cancer pain _ dig External Sci [Internet]. 2008 Mar [ cited 2022 Jul 13];53(3):856–60. available from : https://pubmed.ncbi.nlm.nih.gov/17676392/
15. Wong GY, Schroeder DR, Carns PE, Wilson JL, Martin DP, Kinney MO, et al. Effect of neurolytic celiac plexus block on pain relief , quality of life, and survival in patients with unresectable pancreatic cancer : a randomized controlled trial . JAMA [Internet]. 2004 Mar 3 [ cited 2022 Jul 13];291(9):1092–9. available from : https://pubmed.ncbi.nlm.nih.gov/14996778/
16. Kawamata M, Ishitani K, Ishikawa K, Sasaki H, Ota K, Omote K, et al. Comparison between celiac plexus block and morphine treatment on quality of life in patients with pancreatic cancer pain _ Pain [Internet]. 1996 [ cited 2022 Jul 13];64(3):597–602. available from : https://pubmed.ncbi.nlm.nih.gov/8783327/
17. Bang JY, Sutton B, Hawes RH, Varadarajulu S. EUS- guided celiac ganglion radiofrequency ablation versus celiac plexus neurolysis for palliation of pain in pancreatic cancer : a randomized controlled trial ( with videos ). gastrointestinal Endoscopy [Internet]. 2019;89(1):58-66.e3. available from : https://doi.org/10.1016/j.gie.2018.08.005
18. Ishiwatari H, Hayashi T, Yoshida M, Ono M, Sato T, Miyanishi K, et al. EUS guided celiac plexus neurolysis by using highly viscous phenol-glycerol as a neurolytic agent ( with video). gastrointestinal Endoscopy [Internet]. 2015;81(2):479–83. available from : http://dx.doi.org/10.1016/j.gie.2014.10.031
19. O'Toole TM, Schmulewitz N. Complication rates of EUS- guided celiac plexus blockade and neurolysis : results of a large case series . Endoscopy [Internet]. 2009 [ cited 2022 Jul 13];41(7):593–7. available from : https://pubmed.ncbi.nlm.nih.gov/19588286/
20. Alvarez-Sánchez MV, Jenssen C, Faiss S, Napoléon B. Interventional endoscopic ultrasonography : an overview of safety and costs . Surg Endosc [Internet]. 2014 [ cited 2022 Jul 13];28(3):712–34. available from : https://pubmed.ncbi.nlm.nih.gov/24196551/
21. Sahai A v., Lemelin V, Lam E, Paquin SC. Central vs. bilateral endoscopic ultrasound-guided celiac plexus block or neurolysis : a comparative study of short term effect . Am J Gastroenterol [Internet]. 2009 Feb [ cited 2022 Jul 13];104(2):326–9. available from : https://pubmed.ncbi.nlm.nih.gov/19174816/
22. Minaga K, Kitano M, Imai H, Miyata T, Kudo M. Acute spinal cord infarction after EUS- guided celiac plexus neurolysis _ gastrointestinal Endosc [Internet]. 2016 May 1 [ cited 2022 Jul 13];83(5):1039–40. available from : https://pubmed.ncbi.nlm.nih.gov/26551729/

There are 22 citations in total.

Details

Primary Language	English
Subjects	Clinical Sciences
Journal Section	Original Article
Authors	Uğur Özgürbüz 0000-0002-8268-464X Birzat Emre Gölboyu 0000-0002-2011-2574
Publication Date	December 31, 2022
Submission Date	August 26, 2022
Published in Issue	Year 2022

Cite

Vancouver	Özgürbüz U, Gölboyu BE. Comparison of the Effects of Alcohol and Phenol Used for Celiac Neurolysis with Endoscopic Ultrasound in Patients with Pancreas Cancer: Retrospective Analysis. Genel Tıp Derg. 2022;32(6):746-50.

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