Research Article
BibTex RIS Cite

Herpes Zoster Hastalarının Demografik ve Klinik Özelliklerinin Değerlendirilmesi

Year 2023, , 148 - 153, 30.04.2023
https://doi.org/10.54005/geneltip.1205934

Abstract

Özet
Amaç: Herpes zoster 50 yaş üzerinde daha sık görülen ve post herpetik nevralji gelişmesi
nedeniyle yaşam kalitesini etkileyen bir hastalıktır. Bu çalışmada herpes zoster tanısı almış
hastaların demografik ve klinik özelliklerinin incelenmesi amaçlanmıştır.
Yöntem:: Bu kesitsel çalışmada dermatoloji bölümünde 2013-2020 yılları
arasında herpes zoster tanısı ile izlenen hastaların verileri geriye dönük olarak incelendi.
Bulgular: 440 hastanın 252’si (%57,3) kadın, 188’i (%42,7) erkekti. Yaş ortalaması 48,9±18 yıl
(4- 94 yıl) idi. En sık yerleşim bölgesi %35,5 oranında torakal bölge ve ikinci sırada %21,4
oranında lomber bölgeydi. Dissemine tutulum ve oftalmik zona ileri yaştaki hastalarda daha
sık görüldü (p<0,001). Komorbiditeler arasında en sık saptananlar %12,6 oranı ile
hipertansiyon ve koroner arter hastalığı birlikteliği, %10,3 ile kanser, %5,9 diyabet ve
hipertansiyon birlikteliğiydi. Şiddetli ağrı hastaların %19.7’sinde izlendi ve kadınlarda daha
sıktı (p=0.016). HT+KAH grubunda ve kanser hastalarında orta ve şiddetli ağrı oranı yüksekti
(p˂0.001). 50 yaş üzerindeki hastaların %15,3’ ünde post herpetik nevralji izlendi.
Sonuç: Herpes zoster özellikle yetişkinlerde sıklıkla görülmektedir. Akut ağrı oluşturması
ve postherpetik nevralji gelişebilmesi nedeniyle, özellikle riskli hasta gruplarının takip ve
tedavisine önem gösterilmesi gerekmektedir.

References

  • Nair PA, Patel BC. Herpes Zoster. [Updated 2021 Sep 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.
  • Acer E, Kaya Erdogan H, Bulur I, Acar EM. Evaluation of demographic and clinical characteristics of 166 patients with herpes zoster in the Kırşehir region. Turkderm-Turk Arch Dermatol Venereol. 2018; 52(3): 95-99
  • McCaffery M, Beebe A, et al. Pain: Clinical manual for nursing practice, 1989. Mosby St. Louis, MO.
  • Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J Dermatol Venereol Leprol. 2018 May-Jun;84(3):251-262.
  • Kawai K, Yawn BP, Wollan P, Harpaz R. Increasing incidence of herpes zoster over a 60-year period from a population-based study. Clin Infect Dis. 2016;63(2):221-226.
  • van Oorschot D, Vroling H, Bunge E, Diaz-Decaro J, Curran D, Yawn B. A systematic literature review of herpes zoster incidence worldwide. Hum Vaccin Immunother. 2021 Jun 3;17(6):1714-1732.
  • Kim YJ, Lee CN, Lim CY, Jeon WS, Park YM. Population-based study of the epidemiology of herpes zoster in Korea. J Korean Med Sci. 2014 Dec;29(12):1706-10.
  • Alicino C, Trucchi C, Paganino C, Barberis I, Boccalini S, Martinelli D, Pellizzari B, Bechini A, Orsi A, Bonanni P, Prato R, Iannazzo S, Icardi G. Incidence of herpes zoster and post-herpetic neuralgia in Italy: Results from a 3-years population-based study. Hum Vaccin Immunother. 2017 Feb;13(2):399-404.
  • Suhail M, Ejaz A, Abbas M, Naz S, Suhail T. Herpes zoster: Seasonal variations and morphological patterns in Pakistan. JPAD 2011;21:22‑6
  • Rahman H, Karim R, Tauhid SA, Das AR, Sarkar SK. Is There any Seasonal Influence of Herpes Zoster. Faridpur Medical College Journal. 2017;2:14-17
  • Babamahmoodi F, Alikhani A, Ahangarkani F, Delavarian L, Barani H, Babamahmoodi A. Clinical manifestations of herpes zoster, its comorbidities, and its complications in north of iran from 2007 to 2013. Neurol Res Int. 2015;2015:896098.
  • Kawai K, Yawn BP. Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2017 Dec;92(12):1806-1821.
  • Patki A, Vora A, Parikh R, Kolhapure S, Agrawal A, Dash R. Herpes zoster in outpatient departments of healthcare centers in India: a review of literature. Hum Vaccin Immunother. 2021 Nov 2;17(11):4155-4162.
  • Jardine A, Conaty SJ, Vally H. Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization? Epidemiol Infect 2011; 139:658–65
  • Berlinberg EJ, Kim E, Deiner MS, Patterson C, Porco TC, Acharya NR. Seasonality of herpes zoster and herpes zoster ophthalmicus. J Clin Virol. 2020;126:104306.
  • Korostil IA, Regan DG. Varicella-Zoster Virus in Perth, Western Australia: Seasonality and Reactivation. PLoS One. 2016 Mar 10;11(3):e0151319.
  • Kucukcakir O, Aliagaoglu C, Turan H et al. Retrospective evaluation of patients with herpes zoster followed up in our department between 1999-2010. Turkderm 2012; 46:186-90.
  • Ozkol HU, Bilgili SG, Karadag AS, Altun F, Calka O. The evaluation clinical and demographic characteristics of 115 patients diagnosed with herpes zoster in Eastern Turkey. Turk J Dermatol 2013;7:201-5.
  • Hayran Y, Akpınar Ü, Yalçın B. Herpes Zoster Tanısıyla Takip Edilen Hastaların Demografik, Klinik ve Laboratuvar Özelliklerinin Değerlendirilmesi. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020; 53(Ek Sayı 1): 33-40.
  • Chen SY, Suaya JA, Li Q, Galindo CM, Misurski D, Burstin S, Levin MJ. Incidence of herpes zoster in patients with altered immune function. Infection. 2014 Apr;42(2):325-34.
  • Yenikomshian MA, Guignard AP, Haguinet F, LaCasce AS, Skarin AT, Trahey A, Karner P, Duh MS. The epidemiology of herpes zoster and its complications in Medicare cancer patients. BMC Infect Dis. 2015 Feb 27;15:106.
  • Chuanchaiyakul N, Thongtang N, Rattanaumpawan P. Cumulative incidence of and risk factors for herpes zoster among patients with diabetes mellitus: Results from a 10-year nested case-control study. J Diabetes Complications. 2022 Mar 8:108168. Epub ahead of print.
  • Tanaka K, Kimura E, Oryoji K, Mizuki SI, Kobayashi T, Nishikawa A, Yoshinaga E, Miyake Y. Hypertension and dyslipidemia are risk factors for herpes zoster in patients with rheumatoid arthritis: a retrospective analysis using a medical information database. Rheumatol Int. 2021 Sep;41(9):1633-1639.
  • Toniolo-Neto J, Psaradellis E, Karellis A, Rampakakis E, Rockett TY, Sampalis JS, Johnson KD, Monsanto HA, Acosta CJ. Measuring herpes zoster disease burden in São Paulo, Brazil: a clinico-epidemiological single-center study. Clinics (Sao Paulo). 2018 Jul 19;73:e243.
  • Antoniolli L, Rodrigues C, Borges R, Goldani LZ. Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil. Braz J Infect Dis. 2019 Mar-Apr;23(2):143-145.
  • Mishra S, Rasul A, Usmani H. Role of interventional treatment in acute pain of herpes zoster and prevention of postherpetic neuralgia. Indian J Pain 2019;33:7-10.
  • Jung HY, Park HJ. Pain Management of Herpes Zoster. In: Prostran M, editor. Pain Management [Internet]. London: IntechOpen; 2016. Available from: https://www.intechopen.com/chapters/50380
  • Gauthier A, Breuer J, Carrington D, Martin M, Rémy V. Epidemiology and cost of herpes zoster and post‑herpetic neuralgia in the united kingdom. Epidemiol Infect 2009;137:38‑4.
  • Gialloreti LE, Merito M, Pezzotti P, Naldi L, Gatti A, Beillat M, et al. Epidemiology and economic burden of herpes zoster and post‑herpetic neuralgia in italy: A retrospective, population‑based study. BMC Infect Dis 2010;10:230.
  • Johnson RW, Alvarez-Pasquin MJ, Bijl M, Franco E, Gaillat J, Clara JG, Labetoulle M, Michel JP, Naldi L, Sanmarti LS, Weinke T. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015 Jul;3(4):109-20.

Evaluation of the Demographic and Clinical Characteristics of Patients Diagnosed with Herpes Zoster

Year 2023, , 148 - 153, 30.04.2023
https://doi.org/10.54005/geneltip.1205934

Abstract

Background: Herpes zoster is a disease that is more frequently seen in people aged over 50 years and negatively affects the quality of life due to the development of post-herpetic neuralgia. This study aimed to investigate the demographic and clinical characteristics of patients diagnosed with herpes zoster.
Methods: In this cross-sectional study, the data of patients who were followed up with a diagnosis of herpes zoster at the dermatology department between 2013 and 2020 were retrospectively examined.
Results: Of 440 patients, 252 (57.3%) were female and 188 (42.7%) were male. The mean age was 48.9±18 (4-94) years. The most common localization was the thoracic region at a rate of 35.5% and the lumbar region at a rate of 21.4%. Disseminated and ophthalmic zoster were more common in elderly patients (p<0.001). The most common comorbidities were hypertension (HT)+coronary artery disease (CAD) (12.6%), cancer (10.3%), and diabetes+HT (5.9%). Severe pain was observed in 19.7% of the patients and was more common in women (p=0.016). The rate of moderate and severe pain was high in the patients with HT+CAD and cancer (p˂0.001). Post-herpetic neuralgia was observed in 15.3% of the patients aged over 50.
Conclusions: Herpes zoster is especially common in adults. Since it causes acute pain and can lead to postherpetic neuralgia development, risky patient groups should be more carefully followed up and treated.

References

  • Nair PA, Patel BC. Herpes Zoster. [Updated 2021 Sep 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan-.
  • Acer E, Kaya Erdogan H, Bulur I, Acar EM. Evaluation of demographic and clinical characteristics of 166 patients with herpes zoster in the Kırşehir region. Turkderm-Turk Arch Dermatol Venereol. 2018; 52(3): 95-99
  • McCaffery M, Beebe A, et al. Pain: Clinical manual for nursing practice, 1989. Mosby St. Louis, MO.
  • Koshy E, Mengting L, Kumar H, Jianbo W. Epidemiology, treatment and prevention of herpes zoster: A comprehensive review. Indian J Dermatol Venereol Leprol. 2018 May-Jun;84(3):251-262.
  • Kawai K, Yawn BP, Wollan P, Harpaz R. Increasing incidence of herpes zoster over a 60-year period from a population-based study. Clin Infect Dis. 2016;63(2):221-226.
  • van Oorschot D, Vroling H, Bunge E, Diaz-Decaro J, Curran D, Yawn B. A systematic literature review of herpes zoster incidence worldwide. Hum Vaccin Immunother. 2021 Jun 3;17(6):1714-1732.
  • Kim YJ, Lee CN, Lim CY, Jeon WS, Park YM. Population-based study of the epidemiology of herpes zoster in Korea. J Korean Med Sci. 2014 Dec;29(12):1706-10.
  • Alicino C, Trucchi C, Paganino C, Barberis I, Boccalini S, Martinelli D, Pellizzari B, Bechini A, Orsi A, Bonanni P, Prato R, Iannazzo S, Icardi G. Incidence of herpes zoster and post-herpetic neuralgia in Italy: Results from a 3-years population-based study. Hum Vaccin Immunother. 2017 Feb;13(2):399-404.
  • Suhail M, Ejaz A, Abbas M, Naz S, Suhail T. Herpes zoster: Seasonal variations and morphological patterns in Pakistan. JPAD 2011;21:22‑6
  • Rahman H, Karim R, Tauhid SA, Das AR, Sarkar SK. Is There any Seasonal Influence of Herpes Zoster. Faridpur Medical College Journal. 2017;2:14-17
  • Babamahmoodi F, Alikhani A, Ahangarkani F, Delavarian L, Barani H, Babamahmoodi A. Clinical manifestations of herpes zoster, its comorbidities, and its complications in north of iran from 2007 to 2013. Neurol Res Int. 2015;2015:896098.
  • Kawai K, Yawn BP. Risk Factors for Herpes Zoster: A Systematic Review and Meta-analysis. Mayo Clin Proc. 2017 Dec;92(12):1806-1821.
  • Patki A, Vora A, Parikh R, Kolhapure S, Agrawal A, Dash R. Herpes zoster in outpatient departments of healthcare centers in India: a review of literature. Hum Vaccin Immunother. 2021 Nov 2;17(11):4155-4162.
  • Jardine A, Conaty SJ, Vally H. Herpes zoster in Australia: evidence of increase in incidence in adults attributable to varicella immunization? Epidemiol Infect 2011; 139:658–65
  • Berlinberg EJ, Kim E, Deiner MS, Patterson C, Porco TC, Acharya NR. Seasonality of herpes zoster and herpes zoster ophthalmicus. J Clin Virol. 2020;126:104306.
  • Korostil IA, Regan DG. Varicella-Zoster Virus in Perth, Western Australia: Seasonality and Reactivation. PLoS One. 2016 Mar 10;11(3):e0151319.
  • Kucukcakir O, Aliagaoglu C, Turan H et al. Retrospective evaluation of patients with herpes zoster followed up in our department between 1999-2010. Turkderm 2012; 46:186-90.
  • Ozkol HU, Bilgili SG, Karadag AS, Altun F, Calka O. The evaluation clinical and demographic characteristics of 115 patients diagnosed with herpes zoster in Eastern Turkey. Turk J Dermatol 2013;7:201-5.
  • Hayran Y, Akpınar Ü, Yalçın B. Herpes Zoster Tanısıyla Takip Edilen Hastaların Demografik, Klinik ve Laboratuvar Özelliklerinin Değerlendirilmesi. Ankara Eğitim ve Araştırma Hastanesi Tıp Dergisi. 2020; 53(Ek Sayı 1): 33-40.
  • Chen SY, Suaya JA, Li Q, Galindo CM, Misurski D, Burstin S, Levin MJ. Incidence of herpes zoster in patients with altered immune function. Infection. 2014 Apr;42(2):325-34.
  • Yenikomshian MA, Guignard AP, Haguinet F, LaCasce AS, Skarin AT, Trahey A, Karner P, Duh MS. The epidemiology of herpes zoster and its complications in Medicare cancer patients. BMC Infect Dis. 2015 Feb 27;15:106.
  • Chuanchaiyakul N, Thongtang N, Rattanaumpawan P. Cumulative incidence of and risk factors for herpes zoster among patients with diabetes mellitus: Results from a 10-year nested case-control study. J Diabetes Complications. 2022 Mar 8:108168. Epub ahead of print.
  • Tanaka K, Kimura E, Oryoji K, Mizuki SI, Kobayashi T, Nishikawa A, Yoshinaga E, Miyake Y. Hypertension and dyslipidemia are risk factors for herpes zoster in patients with rheumatoid arthritis: a retrospective analysis using a medical information database. Rheumatol Int. 2021 Sep;41(9):1633-1639.
  • Toniolo-Neto J, Psaradellis E, Karellis A, Rampakakis E, Rockett TY, Sampalis JS, Johnson KD, Monsanto HA, Acosta CJ. Measuring herpes zoster disease burden in São Paulo, Brazil: a clinico-epidemiological single-center study. Clinics (Sao Paulo). 2018 Jul 19;73:e243.
  • Antoniolli L, Rodrigues C, Borges R, Goldani LZ. Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil. Braz J Infect Dis. 2019 Mar-Apr;23(2):143-145.
  • Mishra S, Rasul A, Usmani H. Role of interventional treatment in acute pain of herpes zoster and prevention of postherpetic neuralgia. Indian J Pain 2019;33:7-10.
  • Jung HY, Park HJ. Pain Management of Herpes Zoster. In: Prostran M, editor. Pain Management [Internet]. London: IntechOpen; 2016. Available from: https://www.intechopen.com/chapters/50380
  • Gauthier A, Breuer J, Carrington D, Martin M, Rémy V. Epidemiology and cost of herpes zoster and post‑herpetic neuralgia in the united kingdom. Epidemiol Infect 2009;137:38‑4.
  • Gialloreti LE, Merito M, Pezzotti P, Naldi L, Gatti A, Beillat M, et al. Epidemiology and economic burden of herpes zoster and post‑herpetic neuralgia in italy: A retrospective, population‑based study. BMC Infect Dis 2010;10:230.
  • Johnson RW, Alvarez-Pasquin MJ, Bijl M, Franco E, Gaillat J, Clara JG, Labetoulle M, Michel JP, Naldi L, Sanmarti LS, Weinke T. Herpes zoster epidemiology, management, and disease and economic burden in Europe: a multidisciplinary perspective. Ther Adv Vaccines. 2015 Jul;3(4):109-20.
There are 30 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Article
Authors

Elif Demirci Saadet 0000-0001-7449-7951

Sabir Hasanbeyzade 0000-0002-8774-3362

Early Pub Date April 30, 2023
Publication Date April 30, 2023
Submission Date November 16, 2022
Published in Issue Year 2023

Cite

Vancouver Demirci Saadet E, Hasanbeyzade S. Evaluation of the Demographic and Clinical Characteristics of Patients Diagnosed with Herpes Zoster. Genel Tıp Derg. 2023;33(2):148-53.