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COVID-19 PANDEMİSİ DÖNEMİNDE TÜRK ÇOCUKLARINDA D VİTAMİNİ DURUMU; TEK MERKEZ DENEYİMİ

Year 2023, , 390 - 393, 31.08.2023
https://doi.org/10.54005/geneltip.1212464

Abstract

Amaç: COVID-19 ile ilgili karantina, çocukların güneş ışığına maruz kalma oranını azaltmıştır ve çocuklar 25-hidroksivitamin D [25(OH)D] eksikliğine karşı duyarlı hale gelmiştir. Bu çalışma, pandeminin ilk yılında ve pandemi öncesi 2 yıl süresince bakılmış 25(OH)D düzeylerini incelemeyi amaçlamıştır. Gereç ve Yöntem: Bu çalışmaya 2018 Ekim–2020 Mart tarihleri arasında eşdeğer sağlık kontrolü yaptıran çocuklar dahil edilmiştir ve D vitamini bakılma tarihine göre; 2018 Ekim -2019 Mart (Grup 1), 2019 Ekim ve 2020 Mart (Grup 2), 2020 Ekim ve 2021 Mart (Grup 3) olarak kategorize edilmiştir. Grup 1, 2 ve 3'te çocukların 25(OH)D düzeyleri ile D vitamini eksikliği oranlarını karşılaştırılmıştır. Bulgular: Çocukların pandemi süresince pandemi öncesi yıllara kıyasla ortalama 25(OH)D düzeylerinin COVID-19 sırasında daha düşük olduğunu bulunmuştur(p=0,039). Çalışmada, 0-1 yaş ve 4-7 yaş grubu çocuklarda 25(OH)D eksikliği oranın pandemi öncesi döneme kıyasla daha yüksek olduğu görülmüştür (p= 0.013, p=0.011). Sonuç: 4-7 yaş arası çocuklar arasında daha düşük 25(OH)D seviyeleri, karantina sırasında azalan güneşlenme süresi ile ilişkilidir. Ancak 25(OH)D eksikliğinin bebeklerde görülme oranlarının artması endişe vericidir.

Supporting Institution

Başkent Üniversitesi Tıp ve Sağlık Bilimleri Araştırması

Project Number

KA21/191

Thanks

Tüm hastalarıma ve kurumuma teşekkür ediyorum.

References

  • World Health Organızatıon (2020). Who Announces Covıd-19 Outbreak A Pandemic. Retrieved it from https://www.who.int/europe/emergencies/ situations/covid-19.
  • Saponaro, F., Saba, A., & Zucchi, R. (2020). An Update on Vitamin D Metabolism. International journal of molecular sciences, 21(18), 6573. https://doi.org/10.3390/ijms21186573
  • Holick M. F. (2004). Vitamin D: important in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. The American Journal of clinical nutrition, 79(3), 362–371. https://doi.org/10.1093/ajcn/79.3.362
  • Munns, C. F., Shaw, N., Kiely, M., Specker, B. L., Thacher, T. D., Ozono, K., Michigami, T., Tiosano, D., Mughal, M. Z., Mäkitie, O., Ramos-Abad, L., Ward, L., DiMeglio, L. A., Atapattu, N., Cassinelli, H., Braegger, C., Pettifor, J. M., Seth, A., Idris, H. W., Bhatia, V., … Högler, W. (2016). Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. The Journal of clinical endocrinology and Metabolism, 101(2), 394–415. https://doi.org/10.1210/jc.2015-2175
  • Ye Wz, Reıs Af, Duboıs-Laforgue D, Bellanne-Chantelot C, Tımsıt J, Velho G (2001). Vitamin D Receptor Gene Polymorphisms Are Associated With Obesity İn Type 2 Diabetic Subjects With Early Age Of Onset. Eur J Endocrinol, 145: 181- 186.
  • Saggese G, Vıerucci F, Boot Am, Czech-Kowalska J, Weber G, Camargo Ca, Mallet E, Fanos M, Shaw Jn, Holick Mf (2015). Vitamin D İn Childhood And Adolescence: An Expert Position Statement. Eur J Pediatr,174565-576.
  • Lippi, G., Ferrari, A., & Targher, G. (2021). Is COVID-19 lockdown associated with vitamin D deficiency? European Journal of public health, 31(2), 278–279. https://doi.org/10.1093/eurpub/ckab004.
  • Meoli, M., Muggli, F., Lava, S., Bianchetti, M. G., Agostoni, C., Kocher, C., Bührer, T. W., Ciliberti, L., Simonetti, G. D., & Milani, G. P. (2021). Vitamin D Status in Adolescents during COVID-19 Pandemic: A Cross-Sectional Comparative Study. Nutrients, 13(5), 1467. https://doi.org/10.3390/nu13051467
  • Yu L, Ke HJ, Che D, Luo SL, Guo Y, Wu JL. Effect of Pandemic-Related Confinement on Vitamin D Status Among Children Aged 0-6 Years in Guangzhou, China: A Cross-Sectional Study. Risk Manag Health Policy. 2020 Nov 19;13:2669-2675. Doi: 10.2147/RMHP.S282495. PMID: 33239928; PMCID: PMC7682604.
  • Rustecka A, Maret J, Drab A, Leszczyńska M, Tomaszewska A, Lipińska-Opałka A, Będzichowska A, Kalicki B, Kubiak JZ. The Impact of COVID-19 Pandemic during 2020–2021 on the Vitamin D Serum Levels in the Paediatric Population in Warsaw, Poland. Nutrients. 2021; 13(6):1990. https://doi.org/10.3390/nu13061990
  • Wong RS, Tung KTS, So H-K, Wong WHS, Wong SY, Tsang HW, Tung JYL, Chua GT, Ho MHK, Wong ICK, Ip P. Impact of COVID-19 Pandemic on Serum Vitamin D Level among Infants and Toddlers: An Interrupted Time Series Analysis and before-and-after Comparison. Nutrients. 2021; 13(4):1270. https://doi.org/10.3390/nu13041270.
  • Yılmaz, K., & Şen, V. (2020). Is vitamin D deficiency a risk factor for COVID-19 in children? Pediatric pulmonology, 55(12), 3595–3601. https://doi.org/10.1002/ppul.25106
  • Panfili, F.M., Roversi, M., D’Argenio, P. et al. Possible Role of Vitamin D in COVID-19 Infection in Pediatric Population. J Endocrinol Invest 44, 27–35 (2021). https://doi.org/10.1007/s40618-020-01327-0

Vitamin D Status in Turkish Children During the Covid-19 Pandemic; A Single Center Experience

Year 2023, , 390 - 393, 31.08.2023
https://doi.org/10.54005/geneltip.1212464

Abstract

Objective: COVID-19-related lockdown decreased the children's exposure to sunlight, and they were susceptible to 25-hydroxyvitamin D [25(OH)D] deficiency. The present study aimed to examine the 25(OH)D levels 2 years before and during the first year of the pandemic. Materials and Methods: This study included children who underwent health checks between the equivalent period during 2018 October–2020 March, and they were categorized according to the date vitamin D was checked; 2018 October -2019 March (Group 1), 2019 October and 2020 March (Group 2), 2020 October, and 2021 March (Group 3). We compared the children’s 25(OH)D levels and vitamin D deficiency rates between Groups 1, 2, and 3. Results: We found that the mean of the children's 25(OH)D levels was lower during COVID-19 than in the last two years before the pandemic (p=0.039). The present study showed that the rates of 25(OH)D deficiencies among ages 0-1, and 4-7 were higher during the pandemic than before (p= 0.013, p=0.011). Conclusion: Reduced sunbathing time during confinement is associated with lower 25(OH)D levels among children aged 4–7. Although increased rates of 25(OH)D deficiency in infants are worrying.

Project Number

KA21/191

References

  • World Health Organızatıon (2020). Who Announces Covıd-19 Outbreak A Pandemic. Retrieved it from https://www.who.int/europe/emergencies/ situations/covid-19.
  • Saponaro, F., Saba, A., & Zucchi, R. (2020). An Update on Vitamin D Metabolism. International journal of molecular sciences, 21(18), 6573. https://doi.org/10.3390/ijms21186573
  • Holick M. F. (2004). Vitamin D: important in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. The American Journal of clinical nutrition, 79(3), 362–371. https://doi.org/10.1093/ajcn/79.3.362
  • Munns, C. F., Shaw, N., Kiely, M., Specker, B. L., Thacher, T. D., Ozono, K., Michigami, T., Tiosano, D., Mughal, M. Z., Mäkitie, O., Ramos-Abad, L., Ward, L., DiMeglio, L. A., Atapattu, N., Cassinelli, H., Braegger, C., Pettifor, J. M., Seth, A., Idris, H. W., Bhatia, V., … Högler, W. (2016). Global Consensus Recommendations on Prevention and Management of Nutritional Rickets. The Journal of clinical endocrinology and Metabolism, 101(2), 394–415. https://doi.org/10.1210/jc.2015-2175
  • Ye Wz, Reıs Af, Duboıs-Laforgue D, Bellanne-Chantelot C, Tımsıt J, Velho G (2001). Vitamin D Receptor Gene Polymorphisms Are Associated With Obesity İn Type 2 Diabetic Subjects With Early Age Of Onset. Eur J Endocrinol, 145: 181- 186.
  • Saggese G, Vıerucci F, Boot Am, Czech-Kowalska J, Weber G, Camargo Ca, Mallet E, Fanos M, Shaw Jn, Holick Mf (2015). Vitamin D İn Childhood And Adolescence: An Expert Position Statement. Eur J Pediatr,174565-576.
  • Lippi, G., Ferrari, A., & Targher, G. (2021). Is COVID-19 lockdown associated with vitamin D deficiency? European Journal of public health, 31(2), 278–279. https://doi.org/10.1093/eurpub/ckab004.
  • Meoli, M., Muggli, F., Lava, S., Bianchetti, M. G., Agostoni, C., Kocher, C., Bührer, T. W., Ciliberti, L., Simonetti, G. D., & Milani, G. P. (2021). Vitamin D Status in Adolescents during COVID-19 Pandemic: A Cross-Sectional Comparative Study. Nutrients, 13(5), 1467. https://doi.org/10.3390/nu13051467
  • Yu L, Ke HJ, Che D, Luo SL, Guo Y, Wu JL. Effect of Pandemic-Related Confinement on Vitamin D Status Among Children Aged 0-6 Years in Guangzhou, China: A Cross-Sectional Study. Risk Manag Health Policy. 2020 Nov 19;13:2669-2675. Doi: 10.2147/RMHP.S282495. PMID: 33239928; PMCID: PMC7682604.
  • Rustecka A, Maret J, Drab A, Leszczyńska M, Tomaszewska A, Lipińska-Opałka A, Będzichowska A, Kalicki B, Kubiak JZ. The Impact of COVID-19 Pandemic during 2020–2021 on the Vitamin D Serum Levels in the Paediatric Population in Warsaw, Poland. Nutrients. 2021; 13(6):1990. https://doi.org/10.3390/nu13061990
  • Wong RS, Tung KTS, So H-K, Wong WHS, Wong SY, Tsang HW, Tung JYL, Chua GT, Ho MHK, Wong ICK, Ip P. Impact of COVID-19 Pandemic on Serum Vitamin D Level among Infants and Toddlers: An Interrupted Time Series Analysis and before-and-after Comparison. Nutrients. 2021; 13(4):1270. https://doi.org/10.3390/nu13041270.
  • Yılmaz, K., & Şen, V. (2020). Is vitamin D deficiency a risk factor for COVID-19 in children? Pediatric pulmonology, 55(12), 3595–3601. https://doi.org/10.1002/ppul.25106
  • Panfili, F.M., Roversi, M., D’Argenio, P. et al. Possible Role of Vitamin D in COVID-19 Infection in Pediatric Population. J Endocrinol Invest 44, 27–35 (2021). https://doi.org/10.1007/s40618-020-01327-0
There are 13 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Original Article
Authors

Betül Orhan Kılıç 0000-0002-9949-0470

Serhat Kılıç 0000-0003-3705-4312

Eylem Gül Ateş 0000-0002-6166-2601

Project Number KA21/191
Early Pub Date August 29, 2023
Publication Date August 31, 2023
Submission Date November 30, 2022
Published in Issue Year 2023

Cite

Vancouver Orhan Kılıç B, Kılıç S, Gül Ateş E. Vitamin D Status in Turkish Children During the Covid-19 Pandemic; A Single Center Experience. Genel Tıp Derg. 2023;33(4):390-3.