Evaluation of Visual Evoked Potentials in Children with Neurofibromatosis Type 1 and Comparison With Radiological Findings
The original article was published on April 29, 2022. https://dergipark.org.tr/en/pub/geneltip/article/1015647
Erratum Note
Dergimizin 2022 yılı 32. Cilt 2. Sayısında 144-149 sayfa aralığında yayımlanan "Nörofibromatozis Tip 1 Tanılı Çocuklarda Desen Görsel Uyarılmış Potansiyellerin Değerlendirilmesi ve Radyolojik Bulgularla Karşılaştırılması" başlıklı makalenin erken görünüm aşamasında Gereç ve Yöntem kısmında çalışmanın yapıldığı merkez adı xxxxxxxxxxxxx şeklinde boş bırakılmış, tablo ve figür başlıkları da Türkçe olacak şekilde sehven hatalı olarak yayına alınmıştır. Makalede yer alan hataların giderilmesi için makale tekrardan sunulmuştur.
Abstract
Purpose: It was aimed to examine the pattern visual evoked potentials (P-VEP) of children with neurofibromatosis type 1 (NF type 1) and to evaluate the correlation of P-VEP results with optical gliomas and unidentified bright objects (UBO) associated with NF Type 1.
Materials and Methods: P-VEP and P100 latencies of 28 children including 16 (%57) boys, who were followed up with the diagnosis of NF Type 1 in the Pediatric Neurology Outpatient Clinic in the Dr. Sami Ulus Maternity and Children's Health and Diseases Research and Training Hospital between 2017 and 2020, with a mean age of 9.61 ± 3.7 years of age were compared with the P100 latencies of a control group consisting of 28 healthy children of similar age and gender.
Results: Unidentified bright objects were found in the brain of 82% of the patients by using magnetic resonance imaging, and optic glioma was found in 21% of the patients. P100 latencies were significantly longer in the patient group than in the control group (p = 0.013, p = 0.043). Patients with optic glioma were found to have significantly longer P100 latencies than patients without optic glioma, consistent with the anatomical location of the optic glioma (p = 0.042, p = 0.025).
Conclusion: With this study, it has been shown that the P-VEP test is an objective electrophysiological test that can be used in the functional assessment of visual pathways in children with NF Type 1. We think that the use of the P-VEP test in the clinical follow-up of children with NF Type 1 may be particularly useful in the early detection of optic gliomas.
Keywords
Çocuk, Nörofibromatozis tip 1, Desen görsel uyarılmış potansiyeller
Supporting Institution
Yok
Project Number
Yok
References
- 1. Dunning-Davies BM, Parker AP. Annual review of children with neurofibromatosis type 1. Arch Dis Child Educ Pract Ed 2016 ;101(2):102-11.
- 2. Ferner RE, Huson SM, Thomas N, et al.Guidelines for the diagnosis and management of individuals with neurofibromatosis 1. J Med Genet 2007;44(2):81-8.
- 3. Abramowicz A, Gos M. Neurofibromin in neurofibromatosis type 1-mutations in NF1gene as a cause of disease. Dev Period Med 2014;18(3):297-306.
- 4. Lewis RA, Gerson LP, Axelson KA, et al. Von Recklinghausen neurofibromatosis: II. Incidence of optic gliomata. Ophthalmology 1984;91(8):929-35.
- 5. Rasool N, Odel JG, Kazim M. Optic pathway glioma of childhood. Curr Opin Ophthalmol 2017;28(3):289-95.
- 6. DiPaolo DP, Zimmerman RA, Rorke LB, et al. Neurofibromatosis type 1: pathologic substrate of high-signal-intensity foci in the brain. Radiology 1995;195(3):721-4.
- 7. Szudek J, Friedman J. Unidentified bright objects associated with features of neurofibromatosis 1. Pediatr Neurol 2002;27(2):123-7.
- 8. Jacques C, Dietemann J. Imagerie de la neurofibromatose de type 1. J Neuroradiol 2005;32(3):180-97.
- 9. Sherman J. Visual evoked potential (VEP): Basic concepts and clinical applications. J Am Optom Assoc 1979; 50(1):19-30.
- 10. Jeon J, Oh S, Kyung S. Assessment of visual disability using visual evoked potentials. BMC Ophthalmol 2012;12(1):36.