Magnetic Resonance Imaging Texture Analysis in the Detection of Metastatic Lymph Nodes in Patients with Nasopharyngeal Carcinoma
Abstract
Abstract
Aims: To investigate the role of magnetic resonance imaging (MRI) texture analysis (TA) in the detection of metastatic lymph nodes in patients with nasopharyngeal carcinoma (NPC).
Material and methods: Between January 2020 and October 2021, 15 NPC patients with 32 metastatic lymph nodes and 30 healthy subjects with benign lymph nodes were included in the study. The texture features compared between metastatic and benign lymph nodes. The independent predictor parameters of metastatic lymph nodes were determined using multivariate regression analysis. Receiver operator characteristics (ROC) analysis was used to evaluate the diagnostic performance of the regression models.
Results: The first order texture features did not differ significantly between groups (p>0.05). Except for correlation in metastatic lymph nodes, all gray-level co-occurrence matrix (GLCM) and gray-level run length matrix (GLRLM) features were significantly different (p<0.05). The GLCM features of joint entropy, joint energy, and maximum probability; and the GLRLM features of gray level non uniformity and low gray level run emphasis were independent predictors of metastatic lymph nodes. The area under the curve (AUC) values for the GLCM regression model and GLRLM regression model were 0.975 and 0.928, respectively.
Conclusion: MRI texture analysis may be useful to detect metastatic lymph nodes in patients with NPC by providing quantitative information on tissue heterogeneity and cellular composition.
Keywords
Magnetic resonance imaging, texture analysis, nasopharyngeal carcinoma, metastatic lymph nodes
References
- Guo R, Mao Y-P, Tang L-L, Chen L, Sun Y, Ma J. The evolution of nasopharyngeal carcinoma staging. Br J Radiol 2019;92(1102):20190244.
- King AD. MR Imaging of Nasopharyngeal Carcinoma. Magn Reson Imaging Clin N Am 2022;30(1):19-33.
- Siti-Azrin AH, Norsa'adah B, Naing NN. Prognostic factors of nasopharyngeal carcinoma patients in a tertiary referral hospital: a retrospective cohort study. BMC Res Notes 2017;10(1):705.
- Abdel Khalek Abdel Razek A, King A. MRI and CT of nasopharyngeal carcinoma. AJR Am J Roentgenol 2012;198(1):11-8.
- Lan M, Huang Y, Chen CY, Han F, Wu SX, Tian L, et al. Prognostic Value of Cervical Nodal Necrosis in Nasopharyngeal Carcinoma: Analysis of 1800 Patients with Positive Cervical Nodal Metastasis at MR Imaging. Radiology 2015;276(2):536-44.
- Zhang GY, Liu LZ, Wei WH, Deng YM, Li YZ, Liu XW. Radiologic criteria of retropharyngeal lymph node metastasis in nasopharyngeal carcinoma treated with radiation therapy. Radiology 2010;255(2):605-12.
- Gupta A, Rahman K, Shahid M, Kumar A, Qaseem SM, Hassan SA, et al. Sonographic assessment of cervical lymphadenopathy: role of high-resolution and color Doppler imaging. Head Neck 2011;33(3):297-302.
- Ahuja AT, Ying M. Sonographic evaluation of cervical lymph nodes. AJR Am J Roentgenol 2005;184(5):1691-9.
- Wang XS, Hu CS, Ying HM, Zhou ZR, Ding JH, Feng Y. Patterns of retropharyngeal node metastasis in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2009;73(1):194-201.
- Varghese BA, Cen SY, Hwang DH, Duddalwar VA. Texture Analysis of Imaging: What Radiologists Need to Know. AJR Am J Roentgenol 2019;212(3):520-8.