The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients
Abstract
Background: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acid/HDL ratio (UHR) and monocyte/HDL ratio (MHR) in male subjects with type 2 diabetes.
Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose (HbA1c levels exceeding 7, n=83) and the group with good glycemic control (HbA1c levels at or below 7, n=83). Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein (HDL), uric acid, low-density lipoprotein (LDL), neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acid/HDL ratio, body mass index and monocyte/HDL ratio were compared.
Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group (P<0.001). In contrast, diabetic patients had lower HDL levels than healthy subjects (P=0.002). Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects (P<0.001). UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects (P=0.003). White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group (P<0.001, P<0.001, P=0.002). Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects (P=0.007).
Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.
Keywords
Type 2 diabetes mellitus , Uric acid/HDL ratio , Monocyte/HDL ratio , HbA1C
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