The Use of Propofol to Induce Anesthesia can Mitigate the Oxidative Stress Created by Laparoscopic Cholecystectomy, but not Thiopental

Year 2024, , 554 - 558, 31.08.2024

Ayşe Gül Çeliksu , Şemsi Mustafa Aksoy , Ayça Tuba Dumanlı Özcan , Derya Gokcinar

https://doi.org/10.54005/geneltip.1473649

Abstract

Aim: Laparoscopic cholecystectomy is one of the treatment methods in symptomatic cholelithiasis cases, and pneumoperitoneum has been shown to increase oxidative stress. Our aim is to compare propofol and thiopental in terms of their effects on oxidative stress parameters in laparoscopic cholecystectomy cases.
Materials and Methods: After obtaining Ethics Committee permission, patients who underwent laparoscopic cholecystectomy were divided into thiopental and propofol groups according to the agent used for anesthesia induction in the randomized and prospective study. Serum serum oxidative stress parameters levels were measured in all patients two times, before induction of general anesthesia and at the 30th minute postoperatively.
Results: When comparing the preoperative period with the postoperative period, TAS levels increased statistically significantly in the propofol group (preoperatively 1.21±0.21 mmolH2O2/L, postoperatively 1.31±0.18 mmolH2O2/L, p<0.001) compared to the thiopental group (preoperatively 1.23±0.14 mmolH2O2/L, postoperatively 1.27±0.14 mmolH2O2/L, p=0.055). ARES, serum native thiol, total thiol, and disulfide levels decreased statistically significantly in both groups. While PON1 level did not change in the propofol group, it decreased in the thiopental group.
Conclusion: We concluded that propofol had a significantly greater oxidative stress reduction effect than thiopental. By increasing the TAS levels, propofol may have a more positive effect on oxidative stress than thiopental. However, neither propofol nor thiopental have oxidative stress-reducing effects on other oxidative stress parameters.

Keywords

Antioxidants, Disulfides, Laparoscopic cholecystectomy, Oxidative stress, Propofol, Thiol, Thiopental

Ethical Statement

Yıldırım Beyazıt University Faculty of Medicine Clinical Research Ethics Committee approved the study with decision number 235 on 17 December 2014.

Anestezi Indüksiyonu için Propofol Kullanımı Laparoskopik Kolesistektominin Yarattığı Oksidatif Stresi Hafifletebilir Ancak Tiyopental Bunu Azaltamaz

Abstract

Amaç: Semptomatik kolelitiazis vakalarında laparoskopik kolesistektomi tedavi metodlarından biridir ve pnömoperitoniumun oksidatif stresi arttırdığı gösterilmiştir. Bizim amacımız laparoskopik kolesistektomi olgularında oksidatif stres parametreleri üzerine etkileri açısından propofol ve tiyopentali karşılaştırmaktır.
Gereç ve Yöntem: Etik Kurul izni alındıktan sonra, randomize ve prospektif olarak planlanan çalışmada laparoskopik kolesistektomi geçiren hastalar anestezi indüksiyonu için kullanılan ajana göre tiyopental ve propofol gruplarına ayrıldı. Tüm hastalardan serum oksidatif stres parametreleri düzeylerinin ölçümü için genel anestezi indüksiyonu öncesi ve postoperatif 30. dakikada olmak üzere iki kez kan örnekleri elde edildi.
Bulgular: TAS düzeyleri, preoperatif dönem ile postoperatif dönem karşılaştırıldığında propofol grubunda (preoperatif olarak 1.21±0.21 mmolH2O2/L, postoperatif olarak 1.31±0.18 mmolH2O2/L, p<0.001) thiopental grubuna (preoperatif olarak 1.23±0.14 mmolH2O2/L, postoperatif olarak 1.27±0.14 mmolH2O2/L, p=0.055) göre istatistiksel olarak önemli oranda arttı. ARES, serum native tiyol, toplam tiyol, disülfid düzeyi her iki grupta istatistiksel olarak önemli oranda azaldı. PON1 düzeyi ise propofol grubunda değişmemiş saptanırken, tiyopental grubunda azalmış olarak tespit edilmiştir.
Sonuç: Propofolün tiyopentalden anlamlı derecede daha fazla oksidatif stres azaltma etkisine sahip olduğu sonucuna vardık. TAS düzeylerinde artış sağlayarak, propofol tiyopentale göre oksidatif stres üzerine daha olumlu etkiye sahip olabilir. Ancak diğer oksidatif stres parametreleri üzerine ne propofolün ne de thiopentalin oksidatif stresi azaltıcı etkileri yoktur.

Keywords

Antioksidanlar, Disülfitler, Laparoskopik kolesistektomi, Oksidatif stres, Propofol, Tiyol, Tiyopental

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