The Use of Propofol to Induce Anesthesia can Mitigate the Oxidative Stress Created by Laparoscopic Cholecystectomy, but not Thiopental
Abstract
Aim: Laparoscopic cholecystectomy is one of the treatment methods in symptomatic cholelithiasis cases, and pneumoperitoneum has been shown to increase oxidative stress. Our aim is to compare propofol and thiopental in terms of their effects on oxidative stress parameters in laparoscopic cholecystectomy cases.
Materials and Methods: After obtaining Ethics Committee permission, patients who underwent laparoscopic cholecystectomy were divided into thiopental and propofol groups according to the agent used for anesthesia induction in the randomized and prospective study. Serum serum oxidative stress parameters levels were measured in all patients two times, before induction of general anesthesia and at the 30th minute postoperatively.
Results: When comparing the preoperative period with the postoperative period, TAS levels increased statistically significantly in the propofol group (preoperatively 1.21±0.21 mmolH2O2/L, postoperatively 1.31±0.18 mmolH2O2/L, p<0.001) compared to the thiopental group (preoperatively 1.23±0.14 mmolH2O2/L, postoperatively 1.27±0.14 mmolH2O2/L, p=0.055). ARES, serum native thiol, total thiol, and disulfide levels decreased statistically significantly in both groups. While PON1 level did not change in the propofol group, it decreased in the thiopental group.
Conclusion: We concluded that propofol had a significantly greater oxidative stress reduction effect than thiopental. By increasing the TAS levels, propofol may have a more positive effect on oxidative stress than thiopental. However, neither propofol nor thiopental have oxidative stress-reducing effects on other oxidative stress parameters.
Keywords
Antioxidants, Disulfides, Laparoscopic cholecystectomy, Oxidative stress, Propofol, Thiol, Thiopental
Ethical Statement
Yıldırım Beyazıt University Faculty of Medicine Clinical Research Ethics Committee approved the study with decision number 235 on 17 December 2014.
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