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Akciğerin Sarkomatoid Karsinomlarının Klinik ve Radyometabolik Özellikleri

Year 2019, Volume: 29 Issue: 3, 113 - 118, 01.09.2019

Abstract

Amaç: Akciğerin sarkomatoid karsinomlarının SK klinik ve radyometabolik PET-BT özelliklerinin incelenmesi ve bu özelliklerin sağ kalım üzerine etkisini araştırmak. Gereç ve Yöntem: Ocak 2014-Aralık 2016 arasında akciğer kanseri tanısı alan olguların kayıtları retrospektif olarak incelendi. Küçük hücreli dışı akciğer kanseri KHDAK ve SK tanısı alan olguların dosyaları ayrıldı. Bu olguların klinik ve radyometabolik özellikleri birbirleri ile karşılaştırıldı. Gruplara ait veriler Ki Kare, Mann Whitney U ile karşılaştırıldı. Sağ kalım analizleri Kaplan-Meier, Logrank yöntemi ile hesaplandı. Tüm testlerde p

References

  • Travis WD, Brambilla E, Nicholson AG, et al. WHO Panel. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advan- ces Since the 2004 Classification. J Thorac Oncol 2015; 10: 1243-60.
  • Kefeli M, Yıldız L, Oğuz A, Uzun O, Kandemir B. Akciğerin sarkomatoid karsinomları: Üç olgu sunumu. Türk Patoloji Dergisi 2008; 24: 64-8.
  • Uğurluer G, Atalar B, İkizler HAS ve ark. Serviks Kanserli Hastalarda PET/BT Tetkikinde Primer Tümörün FDG Tu- tulum Derecesi ile Lenf Nodu Metastazı Arasındaki İlişki. ACU Sağlık Bil Derg 2016; 3: 129-33.
  • Sönmezoğlu K. Akciğer kanserlerinde FDG-PET uygula- maları. Tüberküloz ve Toraks Dergisi 2005; 53: 94-112.
  • Cox BL, Mackie TR, Eliceiri KW. The sweet spot: FDG and other 2-carbon glucose analogs for multi-modal metabolic imaging of tumor metabolism.Am J Nucl Med Mol Imaging 2014; 5: 1-13.
  • Rapicetta C, Lococo F, Stefani A, et al. Primary Sarcomatoid Carcinoma of the Lung: Radiometabolic ((18)F-FDG PET/ CT) Findings and Correlation with Clinico-Pathological and Survival Results. Lung 2016; 194: 653-7.
  • Zhang Y, Li B, Shi H, Cai L, Gu Y. Sarcomatoid carcinoma of the lung mimics aspergilloma on ¹⁸F-FDG PET/CT. Hell J Nucl Med 2015; 18: 268-70.
  • Nakajima M, Kasai T, Hashimoto H, Iwata Y, Manabe H. Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases. Cancer 1999; 86: 608-16.
  • Shen XY, Lin ZF, Lin Q, et al. Pulmonary sarcomatoid car- cinoma: a case report. Contemp Oncol (Pozn) 2013; 17: 210–3.
  • Vieira T, Girard N, Ung M, et al. Efficacy of first-line che- motherapy in patients with advanced lung sarcomatoid car- cinoma. J Thorac Oncol 2013; 8: 1574-7.
  • Giroux Leprieur E, Lavole A, Ruppert A-M, et al. Factors as- sociated with long-term survival of patients with advanced non-small cell lung cancer. Respirology 2012; 17: 134-42.
  • Vieira T, Girard N, Ung M, et al. Efficacy of firstline chemo- therapy in patients with advanced lung sarcomatoid carci- noma. J Thorac Oncol 2013; 8: 1574–7.
  • Roesel C, Terjung S, Weinreich G, et al. Sarcomatoid carci- noma of the lung: a rare histological subtype of non-small cell lung cancer with a poor prognosis even at earlier tu- mour stages. Interact Cardiovasc Thorac Surg 2017; 24: 407-13.
  • Martin LW, Correa AM, Ordonez NG, et al. Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg 2007; 84: 973-80.
  • Steuer CE, Behera M, Liu Y, et al. Pulmonary Sarcomatoid Carcinoma: An Analysis of the National Cancer Data Base. Clin Lung Cancer 2017; 18: 286-92.
  • Chang YL, Lee YC, Shih JY, Wu CT. Pulmonary pleomorp- hic (spindle) cell carcinoma: peculiar clinicopathologic ma- nifestations different from ordinary non-small cell carcino- ma. Lung Cancer 2001; 34: 91-7.
  • Fishback NF, Travis WD, Moran CA, et al. Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopatho- logic correlation of 78 cases. Cancer 1994; 73: 2936-45.
  • Rossi G1, Cavazza A, Sturm N, et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003; 27: 311-24.
  • Weissferdt A, Kalhor N, Correa AM, Moran CA. "Sarco- matoid" carcinomas of the lung: a clinicopathological study of 86 cases with a new perspective on tumor classification. Hum Pathol 2017; 63: 14-26.
  • Paesmans M. Facteurs pronostiques du cancer bronchique. Prognostic factors in lung cancer. Rev Mal Respir 2005; 22: 76–80
  • Mochizuki T, Ishii G, Nagai K, et al. Pleomorphic carcino- ma of the lung: clinicopathologic characteristics of 70 cases. Am J Surg Pathol 2008; 32: 1727-35.
  • Paesmans M, Garcia C, Wong CY, et al. Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data. Eur Respir J 2015; 46: 1751-61.
  • Ciarallo A, Makis W, Novales-Diaz JA, Lisbona R. Sarcoma- toid carcinoma (carcinosarcoma) of the lung mimics malig- nant pleural mesothelioma on 18F-FDG PET/CT: a report of 2 cases. Clin Nucl Med 2012; 37: 416-9.
  • Pelosi G, Sonzogni A, De Pas T, et al. Review article: pul- monary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol 2010; 18: 103-20.
Year 2019, Volume: 29 Issue: 3, 113 - 118, 01.09.2019

Abstract

Objective: To investigate the clinical and radiometabolic PET-CT characteristics of lung sarcomatoid carcinomas SC and to investigate the effect on survival.Material and Methods: Patients diagnosed with lung cancer between January 2014 and December 2016 were retrospectively analyzed. Clinical and radiometabolic characteristics of non-small cell lung carcinoma and sarcomatoid cancer were compared with each other. All data was analyzed by Chi square, Mann Whitney U, Kaplan-Meier Logrank method. In all tests p

References

  • Travis WD, Brambilla E, Nicholson AG, et al. WHO Panel. The 2015 World Health Organization Classification of Lung Tumors: Impact of Genetic, Clinical and Radiologic Advan- ces Since the 2004 Classification. J Thorac Oncol 2015; 10: 1243-60.
  • Kefeli M, Yıldız L, Oğuz A, Uzun O, Kandemir B. Akciğerin sarkomatoid karsinomları: Üç olgu sunumu. Türk Patoloji Dergisi 2008; 24: 64-8.
  • Uğurluer G, Atalar B, İkizler HAS ve ark. Serviks Kanserli Hastalarda PET/BT Tetkikinde Primer Tümörün FDG Tu- tulum Derecesi ile Lenf Nodu Metastazı Arasındaki İlişki. ACU Sağlık Bil Derg 2016; 3: 129-33.
  • Sönmezoğlu K. Akciğer kanserlerinde FDG-PET uygula- maları. Tüberküloz ve Toraks Dergisi 2005; 53: 94-112.
  • Cox BL, Mackie TR, Eliceiri KW. The sweet spot: FDG and other 2-carbon glucose analogs for multi-modal metabolic imaging of tumor metabolism.Am J Nucl Med Mol Imaging 2014; 5: 1-13.
  • Rapicetta C, Lococo F, Stefani A, et al. Primary Sarcomatoid Carcinoma of the Lung: Radiometabolic ((18)F-FDG PET/ CT) Findings and Correlation with Clinico-Pathological and Survival Results. Lung 2016; 194: 653-7.
  • Zhang Y, Li B, Shi H, Cai L, Gu Y. Sarcomatoid carcinoma of the lung mimics aspergilloma on ¹⁸F-FDG PET/CT. Hell J Nucl Med 2015; 18: 268-70.
  • Nakajima M, Kasai T, Hashimoto H, Iwata Y, Manabe H. Sarcomatoid carcinoma of the lung: a clinicopathologic study of 37 cases. Cancer 1999; 86: 608-16.
  • Shen XY, Lin ZF, Lin Q, et al. Pulmonary sarcomatoid car- cinoma: a case report. Contemp Oncol (Pozn) 2013; 17: 210–3.
  • Vieira T, Girard N, Ung M, et al. Efficacy of first-line che- motherapy in patients with advanced lung sarcomatoid car- cinoma. J Thorac Oncol 2013; 8: 1574-7.
  • Giroux Leprieur E, Lavole A, Ruppert A-M, et al. Factors as- sociated with long-term survival of patients with advanced non-small cell lung cancer. Respirology 2012; 17: 134-42.
  • Vieira T, Girard N, Ung M, et al. Efficacy of firstline chemo- therapy in patients with advanced lung sarcomatoid carci- noma. J Thorac Oncol 2013; 8: 1574–7.
  • Roesel C, Terjung S, Weinreich G, et al. Sarcomatoid carci- noma of the lung: a rare histological subtype of non-small cell lung cancer with a poor prognosis even at earlier tu- mour stages. Interact Cardiovasc Thorac Surg 2017; 24: 407-13.
  • Martin LW, Correa AM, Ordonez NG, et al. Sarcomatoid carcinoma of the lung: a predictor of poor prognosis. Ann Thorac Surg 2007; 84: 973-80.
  • Steuer CE, Behera M, Liu Y, et al. Pulmonary Sarcomatoid Carcinoma: An Analysis of the National Cancer Data Base. Clin Lung Cancer 2017; 18: 286-92.
  • Chang YL, Lee YC, Shih JY, Wu CT. Pulmonary pleomorp- hic (spindle) cell carcinoma: peculiar clinicopathologic ma- nifestations different from ordinary non-small cell carcino- ma. Lung Cancer 2001; 34: 91-7.
  • Fishback NF, Travis WD, Moran CA, et al. Pleomorphic (spindle/giant cell) carcinoma of the lung. A clinicopatho- logic correlation of 78 cases. Cancer 1994; 73: 2936-45.
  • Rossi G1, Cavazza A, Sturm N, et al. Pulmonary carcinomas with pleomorphic, sarcomatoid, or sarcomatous elements: a clinicopathologic and immunohistochemical study of 75 cases. Am J Surg Pathol 2003; 27: 311-24.
  • Weissferdt A, Kalhor N, Correa AM, Moran CA. "Sarco- matoid" carcinomas of the lung: a clinicopathological study of 86 cases with a new perspective on tumor classification. Hum Pathol 2017; 63: 14-26.
  • Paesmans M. Facteurs pronostiques du cancer bronchique. Prognostic factors in lung cancer. Rev Mal Respir 2005; 22: 76–80
  • Mochizuki T, Ishii G, Nagai K, et al. Pleomorphic carcino- ma of the lung: clinicopathologic characteristics of 70 cases. Am J Surg Pathol 2008; 32: 1727-35.
  • Paesmans M, Garcia C, Wong CY, et al. Primary tumour standardised uptake value is prognostic in nonsmall cell lung cancer: a multivariate pooled analysis of individual data. Eur Respir J 2015; 46: 1751-61.
  • Ciarallo A, Makis W, Novales-Diaz JA, Lisbona R. Sarcoma- toid carcinoma (carcinosarcoma) of the lung mimics malig- nant pleural mesothelioma on 18F-FDG PET/CT: a report of 2 cases. Clin Nucl Med 2012; 37: 416-9.
  • Pelosi G, Sonzogni A, De Pas T, et al. Review article: pul- monary sarcomatoid carcinomas: a practical overview. Int J Surg Pathol 2010; 18: 103-20.
There are 24 citations in total.

Details

Primary Language Turkish
Journal Section Original Article
Authors

Coşkun Doğan This is me

Nesrin Kıral This is me

Elif Torun Parmaksız This is me

Seda Beyhan Sağmen This is me

Ali Fidan This is me

Banu Salepçi This is me

Sevda Şener Cömert This is me

Publication Date September 1, 2019
Published in Issue Year 2019 Volume: 29 Issue: 3

Cite

Vancouver Doğan C, Kıral N, Parmaksız ET, Sağmen SB, Fidan A, Salepçi B, Cömert SŞ. Akciğerin Sarkomatoid Karsinomlarının Klinik ve Radyometabolik Özellikleri. Genel Tıp Derg. 2019;29(3):113-8.