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Sabah ve Gece Yapılan Aerobik Egzersizin Antrenmanlı Deneklerde Serum İrisin Düzeyine Etkilerinin Belirlenmesi

Year 2017, Volume: 27 Issue: 1, 1 - 5, 01.03.2017

Sermin Algül Oğuz Özçelik Mustafa Deniz Fatma Baydaş Fatih Tan

Abstract

Amaç: Egzersizin enerji homeostazisinin düzenlenmesinde önemli yararlı etkileri olduğu bilinmektedir. Enerji düzenlenmesi ile ilgili hormon düzeylerinin değişiminde egzersizin etkisi araştırmacılar arasında yoğun bir ilgiye sahip olan ilginç bir konudur ve irisin bu konuda özel bir öneme sahiptir. Bu çalışmada antrenmanlılarda irisin düzeyine sabah ve gece yapılan akut egzersizin olası yararlı etkilerinin araştırılması amaçlanmıştır.Gereç ve Yöntem: Yirmi antrenmanlı erkek denek sabah ve geceaerobik egzersiz koşu egzersizine katılmışlardır. Egzersizden önce ve sonra venöz kan örnekleri alınmıştır. Serum irisin düzeyi ELISA yöntemiyle ölçülmüştür.Bulgular: Bazal irisin düzeyi her iki testte de istatistiksel olarak anlamlı değişmemiştir. Fakat irisin düzeyi sabah 262.01±37 ng/ml’den 299.74±39 ng/ml’ye ve gece 268.57±30 ng/ml’den 316.04±33 ng/ml’ye istatistiksel olarak anlamlı oranda artış göstermiştir p < 0.0001 . Sonuç: Bu çalışma sonuçları egzersiz antrenmanı zamanının antrenmanlı deneklerde irisin düzeyinde farklı etkilere sahip olmadığını göstermektedir.Bu deneysel düzenek egzersizin enerji düzenlenmesinde bir role sahip olan irisini artırdığını açıkça göstermektedir

Keywords

Enerji egzersiz zamanı irisin metabolizma

References

  • Boström P, Wu J, Jedrychowski MP, et al. A PGC1 α de- pendent myokine that drives Brown fat-like development of white fat and thermogenesis. Nature 2012;481:463-8.
  • Mahajan RD, Patra SK. Irisin, a novel myokine responsible- for exercise induced browning ofwhite adipose tissue. Indi- an J ClinBiochem 2013;28:102-3.
  • Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in se- rum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Me- tabolism 2012;61:1725-38.
  • Zhu D, Wang H, Zhang J, et al. Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nit- rative stresses. J Mol Cell Cardiol 2015;87:138-47.
  • Tsuchiya Y, Ando D, Goto K, et al. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med 2014;233:135-40.
  • Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma iri- sin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 2014;171:343-52.
  • Brenmoehl J, Albrecht E, Komolka K, et al. Irisin is elevated in skeletal muscle and serum of mice immediately after acu- te exercise. Int J Biol Sci 2014;10:338-49.
  • Kim HJ, So B, Choi M, Kang D, Song W. Resistance exer- cise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. ExpGerontol 2015;70:11-7.
  • Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol 2014;65:449-54.
  • Pekkala S, Wiklund PK, Hulmi JJ, et al. Are skeletal musc- le FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol 2013;591:5393- 5400.
  • Kurdiova T, Balaz M, Vician M, et al. Effects of obesity, diabetes and exercise on Fndc5 gene expressionand irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014;592:1091–1107.
  • Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans – resultsfrom a randomized- controlled training trial. BMC Med 2013;11:235.
  • Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and brow- ning of subcutaneous adipose tissue in humans. FEBS J 2014;281:739–49.
  • Qiu S, Cai X, Sun Z, et al. Chronic Exercise Training and- Circulating Irisin in Adults: A Meta-Analysis. Sports Med 2015;45:1577-88.
  • Kaya H, Ozcelik O. Tıp Öğrencilerinde Bir Yılda Vücut Kompozisyonlarında Meydana Gelen Değişimlerin Belir- lenmesi. Firat Med J 2005;10:164-8.
  • Karvonen JJ, Kentala E, Mustala O. The effects of training on heart rate: a "longitudinal" study. Ann Med Exp Biol- Fenn 1957;35:307-15.
  • American College of Sports Medicine (ACSM). Guidelines for ExerciseTestingand Prescription (9th ed.). Baltimore, MD: Lippincott, Williams andWilkins, 2014.
  • Ozcelik O, Ozkan Y, Algul S, Colak R. Beneficial effects of training at the anaerobic threshold in addition to pharma- co therapy on weight loss, body composition, and exercise performance in women with obesity.Patient Prefer Adhe- rence 2015;9:999-1004.
  • Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 2013;8:60563.
  • Scalzo RL, Peltonen GL, Giordano GR, et al. Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PLoS One 2014;9:90696.
  • Swick AG, Orena S, O'Connor A. Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Meta- bolism2013;62:1070-73.
  • Loeffler D, Mueller U, Scheuermann K, et al. Serum irisin levels are regulated by acute strenuous exercise. J ClinEn- docrinolMetab 2015;100:1289-99.
  • Anastasilakis AD, Polyzos SA, Saridakis ZG, et al. Circula- ting irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with- gender, physical activity, diet, and body composition. J Clin Endocrinol Metab 2014;99:3247-355.
  • Tsuchiya Y, Ando D, Takamatsu K, Goto K. Resistance exer- cise induces a greater irisin response than endurance exer- cise. Metabolism 2015;64:1042-50.
  • Kurdiova T, Balaz M, Vician M, et al. Effects of obesity, di- abetes and exercise on Fndc5 gene expression and irisin re- lease in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014;592:1091-107.
  • Irving BA, Still CD, Argyropoulos G. Does irisin have a bri- te future as a therapeuticagent in humans? Curr Obes Rep 2014;3:235-41.

Year 2017, Volume: 27 Issue: 1, 1 - 5, 01.03.2017

Sermin Algül Oğuz Özçelik Mustafa Deniz Fatma Baydaş Fatih Tan

Abstract

Objective: It is known that exercise has important beneficial effects on regulation of energy homeostasis. Effect of exercise on alteration of hormone levels engaged in energy regulation is an interesting topic that has obtained a lot of consideration among investigators, with a special attention on irisin. This study was aimed to investigate possible beneficial effect of acute exercise, performed at morning and at night on irisin levels in trained subjects. Materials and Methods: Twenty trained male subjects performed aerobic running exercise in morning and at night. Pre and post exercise venous blood samples were taken. Serum irisin levels were analysed using Enzyme Linked-Immunosorbent Assay. Results: Baseline irisin levels were not statistically significantly different in both tests. However, irisin levels were increased significantly in morning from 262.01±37 ng/ml to 299.74±39 ng/ml and night from 268.57±30 ng/ml to 316.04±33 ng/ml p < 0.0001 . Conclusion: This study documents that time of exercise workout has no different effects on irisin levels in trained subjects. This experimental setting is clearly showed that exercise increases in irisin levels that have roles in regulation of energy expenditure

Keywords

Energy exercise time irisin metabolism

References

  • Boström P, Wu J, Jedrychowski MP, et al. A PGC1 α de- pendent myokine that drives Brown fat-like development of white fat and thermogenesis. Nature 2012;481:463-8.
  • Mahajan RD, Patra SK. Irisin, a novel myokine responsible- for exercise induced browning ofwhite adipose tissue. Indi- an J ClinBiochem 2013;28:102-3.
  • Huh JY, Panagiotou G, Mougios V, et al. FNDC5 and irisin in humans: I. Predictors of circulating concentrations in se- rum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise. Me- tabolism 2012;61:1725-38.
  • Zhu D, Wang H, Zhang J, et al. Irisin improves endothelial function in type 2 diabetes through reducing oxidative/nit- rative stresses. J Mol Cell Cardiol 2015;87:138-47.
  • Tsuchiya Y, Ando D, Goto K, et al. High-intensity exercise causes greater irisin response compared with low-intensity exercise under similar energy consumption. Tohoku J Exp Med 2014;233:135-40.
  • Daskalopoulou SS, Cooke AB, Gomez YH, et al. Plasma iri- sin levels progressively increase in response to increasing exercise workloads in young, healthy, active subjects. Eur J Endocrinol 2014;171:343-52.
  • Brenmoehl J, Albrecht E, Komolka K, et al. Irisin is elevated in skeletal muscle and serum of mice immediately after acu- te exercise. Int J Biol Sci 2014;10:338-49.
  • Kim HJ, So B, Choi M, Kang D, Song W. Resistance exer- cise training increases the expression of irisin concomitant with improvement of muscle function in aging mice and humans. ExpGerontol 2015;70:11-7.
  • Czarkowska-Paczek B, Zendzian-Piotrowska M, Gala K, Sobol M, Paczek L. One session of exercise or endurance training does not influence serum levels of irisin in rats. J Physiol Pharmacol 2014;65:449-54.
  • Pekkala S, Wiklund PK, Hulmi JJ, et al. Are skeletal musc- le FNDC5 gene expression and irisin release regulated by exercise and related to health? J Physiol 2013;591:5393- 5400.
  • Kurdiova T, Balaz M, Vician M, et al. Effects of obesity, diabetes and exercise on Fndc5 gene expressionand irisin release in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014;592:1091–1107.
  • Hecksteden A, Wegmann M, Steffen A, et al. Irisin and exercise training in humans – resultsfrom a randomized- controlled training trial. BMC Med 2013;11:235.
  • Norheim F, Langleite TM, Hjorth M, et al. The effects of acute and chronic exercise on PGC-1alpha, irisin and brow- ning of subcutaneous adipose tissue in humans. FEBS J 2014;281:739–49.
  • Qiu S, Cai X, Sun Z, et al. Chronic Exercise Training and- Circulating Irisin in Adults: A Meta-Analysis. Sports Med 2015;45:1577-88.
  • Kaya H, Ozcelik O. Tıp Öğrencilerinde Bir Yılda Vücut Kompozisyonlarında Meydana Gelen Değişimlerin Belir- lenmesi. Firat Med J 2005;10:164-8.
  • Karvonen JJ, Kentala E, Mustala O. The effects of training on heart rate: a "longitudinal" study. Ann Med Exp Biol- Fenn 1957;35:307-15.
  • American College of Sports Medicine (ACSM). Guidelines for ExerciseTestingand Prescription (9th ed.). Baltimore, MD: Lippincott, Williams andWilkins, 2014.
  • Ozcelik O, Ozkan Y, Algul S, Colak R. Beneficial effects of training at the anaerobic threshold in addition to pharma- co therapy on weight loss, body composition, and exercise performance in women with obesity.Patient Prefer Adhe- rence 2015;9:999-1004.
  • Roca-Rivada A, Castelao C, Senin LL, et al. FNDC5/irisin is not only a myokine but also an adipokine. PLoS One 2013;8:60563.
  • Scalzo RL, Peltonen GL, Giordano GR, et al. Regulators of human white adipose browning: evidence for sympathetic control and sexual dimorphic responses to sprint interval training. PLoS One 2014;9:90696.
  • Swick AG, Orena S, O'Connor A. Irisin levels correlate with energy expenditure in a subgroup of humans with energy expenditure greater than predicted by fat free mass. Meta- bolism2013;62:1070-73.
  • Loeffler D, Mueller U, Scheuermann K, et al. Serum irisin levels are regulated by acute strenuous exercise. J ClinEn- docrinolMetab 2015;100:1289-99.
  • Anastasilakis AD, Polyzos SA, Saridakis ZG, et al. Circula- ting irisin in healthy, young individuals: day-night rhythm, effects of food intake and exercise, and associations with- gender, physical activity, diet, and body composition. J Clin Endocrinol Metab 2014;99:3247-355.
  • Tsuchiya Y, Ando D, Takamatsu K, Goto K. Resistance exer- cise induces a greater irisin response than endurance exer- cise. Metabolism 2015;64:1042-50.
  • Kurdiova T, Balaz M, Vician M, et al. Effects of obesity, di- abetes and exercise on Fndc5 gene expression and irisin re- lease in human skeletal muscle and adipose tissue: in vivo and in vitro studies. J Physiol 2014;592:1091-107.
  • Irving BA, Still CD, Argyropoulos G. Does irisin have a bri- te future as a therapeuticagent in humans? Curr Obes Rep 2014;3:235-41.
There are 26 citations in total.

Details

Primary Language Turkish
Journal Section Original Article
Authors

Sermin Algül This is me

Oğuz Özçelik This is me

Mustafa Deniz This is me

Fatma Baydaş This is me

Fatih Tan This is me

Publication Date March 1, 2017
Published in Issue Year 2017 Volume: 27 Issue: 1

Cite

Vancouver Algül S, Özçelik O, Deniz M, Baydaş F, Tan F. Sabah ve Gece Yapılan Aerobik Egzersizin Antrenmanlı Deneklerde Serum İrisin Düzeyine Etkilerinin Belirlenmesi. Genel Tıp Derg. 2017;27(1):1-5.

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