Atriyal natriüretik peptid infüzyonunun izole sıçan kalbinde iskemi sonrası oluşturduğu hemodinamik değişikliklerde egzersizin rolü

Year 2015, Volume: 25 Issue: 2, 40 - 45, 01.06.2015

Selma Arzu Vardar Orkide Palabıyık Tülin Yalta Serap Topçu Özen Zuhal Guksu Ruhan Topuz Çetin Hakan Karadağ

Abstract

Amaç: Bu çalışmada düşük akımlı iskemi sonrası reperfüzyon döneminde atriyal natriüretik peptid ANP uygulamasının sol ventrikül hemodinamik yanıtlarına etkisi ve bu etkide egzersizin rolü araştırıldı. Gereç ve yöntem: Çalışmada yer alan tüm sıçanlara 60 dakika düşük akımlı iskemi ve takiben 120 dk reperfüzyon uygulandı. Egzersiz E gruplarına ardışık olarak beş gün süreyle yürüyüş egzersizini takiben iskemi ve reperfüzyon uygulandı. Reperfüzyonun ilk 15 dakikasında 0.1 μM/L ANP infüzyonu yapılan iki grup; ANP n=6 ve Egzersiz-ANP n=6 gruplarını oluşturdu. Tüm gruplarda sol ventrikül gelişim basıncı SVGB , maksimum ve minimum sol ventrikül basınç değişim oranları +dP/dt and -dP/dt kaydedildi. Bulgular: Kontrol K , E, ANP ve E-ANP gruplarının SVGB, +dp/dt, -dp/dt ve kalp hızı değerleri iskemi öncesinde ve iskemi sonrası reperfüzyonun 1, 60 ve 120. dakikalarında karşılaştırıldığında gruplar arasında istatistiksel olarak anlamlı bir farklılık göstermedi. Benzer şekilde infarkt alanlarının yüzde değerleri karşılaştırıldığında dört grup arasında istatistiksel olarak anlamlı farklılık bulunmadı. Sonuç: Kısa süreli yoğun egzersiz, reperfüzyon döneminde ANP uygulamasına bağlı kardiyak kontraktilitede oluşan değişimleri etkilememektedir

Keywords

Egzersiz, atriyal natriüretik peptid, iskemi, reperfüzyon, kalp

The Role of Exercise on The Hemodynamic Alterations Which Was Occur Following İnfusion of Atrial Natriuretic Peptid After İschemia in İsolated Perfused Rat Heart

Abstract

Objectives: The effect of atrial natriuretic peptide ANP infusion on left ventricle hemodynamic responses following low flow isch- emia and the role of exercise in this effect were investigated in this study. Material and methods: All rats were applied low flow ischemia during 60 minutes and reperfusion during 120 minutes. Ischemia and reperfusion were applied for Exercise E groups throughout five consecutive days following Walking exercise. Two groups which were applied 0.1 μM/L ANP at the first 15 minutes of exercise constituted ANP n=6 and Exercise-ANP n=6 groups. Left ventricle developed pressure LVDP , maximum-minimum rates of change in left ventricular pressure +dP/dtmax and -dP/dt were recorded in all groups. Results: When SVGB, +dp/dt, -dp/ dt and heart rate values of LVDP, dP/dtmax and dP/dtmin were compared before ischemia and after at 1st, 60th and 120th minutes of reperfusion a statistically significant difference was not observed among groups. Similarly, when percent values of infarct areas were compared a statistically significant difference was not found among four groups. Conclusion: Short duration and intense exercise may not affect the alterations occurred at cardiac contractility resulted from ANP application in reperfusion period

Keywords

Exercise, atrial natriuretic peptide, ischemia, reperfusion, heart

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