Nöromiyelitis optika

Year 2014, Volume: 24 Issue: 3, 112 - 114, 01.01.2014

Tuba Berra Sarıtaş Alper Yosunkaya Hale Borazan Ahmet Keçecioğlu

Abstract

Nöromyelitis optika, nadir görülen ancak oldukça ciddi bir demiyelinizan hastalıktır. Optik sinirlerin ve spinal kordun akut ya da tekrarlayan demiyelinizan enflamasyonu ile görülür. Yirmibir yaşında, kadın hasta, akut görme kaybı, tetrapleji ve solunum arresti nedeniyle yoğun bakım ünitesine kabul edildi. Beyin omurilik sıvısında pleositoz, ve artmış protein seviyesi tespit edildi. Ig G ye bağlı oligoklonal bant formasyonu negatifti. Kraniyal manyetik rezonans görüntülemesinde periventriküler bölgede, mezensefalonda ve sol temporal lob subkortikal bölgede demyelinizasyon mevcuttu. Aynı zamanda servikomeduller bileşkeden servikal vertebra 2. seviyeye kadar uzanan demiyelinizasyon vardı. Hasta steroid ve azotiyopirin tedavisine cevap vermedi. Ancak plazmaferez olgunun kliniğinde dramatik bir iyileşme sağladı

Keywords

Nöromiyelitis optika, plazmaferez, steroid

Neuromyelitis optica

Abstract

Neuromyelitis optica is a rare but severe demyelinating disease. It is represented with acute or relapsing inflammatory demyelination of optic nerves and spinal cord. A 21 year old woman was admitted to intensive care unit with acute visual loss, tetraplegia and respiratory arrest. The cerebrospinal fluid included prominent pleosytosis and increased protein level. Oligoclonal band formation of Ig G is negative. There were demyelination in the periventricular region, mesencephalon and left temporal lobe subcortical region in the cranial magnetic resonance imaging. Also demyelination present from cervicomedullar junction to cervical 2 vertebrae level. The patient did not respond to steroid and azothiyopirine treatment. But plasmapheresis provided a dramatic improvement in her clinical status

Keywords

Neuromyelitis optica, plasmapheresis, steroid

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