İdyopatik Hirşutizm Hastalarında QT Dispersiyonu

Year 2013, Volume: 23 Issue: 1, 10 - 14, 01.01.2013

Tolga Çimen Evrim Çakır Mehmet Doğan Mustafa Gökhan Vural Uğur Arslantaş Sadık Açıkel Ekrem Yeter Tuncay Delibaşı

Abstract

Amaç: Çalışmada idyopatik hirşutizm tanılı hastaların QT dispersiyonu açısından değerlendirilmesi amaçlanmıştır. Metod: 28 İH hastası ve kontrol grubu olarak 35 sağlıklı kadın çalışmaya dahil edildi. Hastaların hormonal incelemeleri ile birlikte elektrokardiyografi EKG analizleri yapılarak QT dispersiyonları QTd ile düzeltilmiş QT QTc değerleri kullanılarak düzeltilmiş QT dispersiyon QTcd değerleri elde edilmiştir. Bulgular: İH ve kontrol hastalarının minimum QT 336±30; 337±32 ms , maksimum QT 358±30; 358±34 ms , minimum QTc 391 ± 24; 399 ± 25 ms ; maksimum QTc 417 ± 24; 424 ± 26 ms , QTd 22±5; 21±7, P=0.6 ve QTcd 26 ± 6, 25 ± 9 ms, P= 0.7 değerleri arasındaki fark istatistiksel olarak anlamsızdı. Hirşutizm hastalarında açlık insülin, Homeostasis model assessment HOMA indeksi ve androjen düzeyleri anlamlı olarak yüksek saptandı. Sonuç: Hormonal ve metabolik bozukluklara rağmen İH hastalarında sağlıklı kadınlara göre anlamlı QT dispersiyonu saptanmamıştır

Keywords

Kardiyak aritmi, insülin direnci, testosteron, hirşutizm

QT Dispertion in Patients With İdiopathic Hirsutism

Abstract

Objective: Our study purposed to evaluate QT dispertion in idiopathic hirsutism IH patients. Method: Study included 28 IH patient and 35 healty women as control group. Patient’s hormonal workups and electrocardiograms ECG analyzed and QT dispertion QTd and corrected QT dispertion QTcd values were calculated. Results: Minimum QT 336±30; 337±32 ms , maximum QT 358±30; 358±34 ms , minimum QTc 391 ± 24; 399 ± 25 ms ; maximum QTc 417 ± 24; 424 ± 26 ms , QTd 22±5; 21±7, P=0.6 and QTcd 26 ± 6, 25 ± 9 ms, P= 0.7 values were not significantly different between IH and healthy women. Fasting insulin, Homeostasis model assessment HOMA index and androgen levels were significantly high in IH patients. Conclusion: Despite differences in hormonal and metabolic pattern, our data demonstrate no significant difference in ECG pattern in IH compared to healthy controls

Keywords

Cardiac arrhythmia, insulin resistance, testosterone, hirsutism

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