Sklerodermalı hastalarda karotis intima-media kalınlığı ile subklinik aterosklerozun değerlendirilmesi

Year 2022, Volume: 32 Issue: 1, 61 - 67, 28.02.2022

Sina Alı , Demet Menekse Gerede , Kerim Esenboğa , Murat Turgay Mustafa Kılıçkap

https://doi.org/10.54005/geneltip.1029623

Abstract

Amaç: Enflamasyon ateroskleroz gelişiminde önemli bir role sahiptir. Enflamatuvar aktivitenin yüksek olduğu sistemik lupus eritematozus ve romatoid artrit gibi hastalıkları olan hastalarda ateroskleroz ve ateroskleroza bağlı gelişebilecek komplikasyon riski sağlıklı bireylere göre daha yüksektir. Bununla birlikte, birkaç çalışma sklerodermalı hastalarda çelişkili sonuçlar göstermiştir. Bu çalışmada karotis intima-media kalınlığı (KİMK) kullanılarak sklerodermalı hastalar ve kontrol grubu karşılaştırıldı.
Yöntemler: Çalışmaya skleroderma tanısı konan 30 hasta (ortalama yaş 51.3 ± 11.8 yıl) ve 30 sağlıklı gönüllü dahil edildi. Gruplar yaş, cinsiyet ve ateroskleroz için risk faktörleri açısından benzerdi.
Bulgular: Gruplar arasında yaş, cinsiyet, lipid düzeyi, hipertansiyon ve diabetes mellitus prevalansı açısından istatistiksel olarak anlamlı fark yoktu (p>0.05). Ortalama KİMK (skleroderma grubu: 0.070±0.011, kontrol grubu: 0.048±0.008, p<0.001) ve maksimum KİMK sklerodermalı hastalarda (skleroderma grubu: 0.076±0.013, kontrol grubu: 0.054±0.009, p<0.001) istatistiksel olarak anlamlı derecede yüksekti. Ayrıca ortalama KİMK ile hsCRP arasında (r=0.48, p<0.001) ve ortalama KİMK ile eritrosit sedimantasyon hızı arasında (r=0.50, p=0.007) skleroderma grubunda istatistiksel olarak anlamlı fark izlendi. Diffüz tip sklerodermalı hastalarda maksimum KİMK ve ortalama KİMK, lokalize sklerodermalı hastalara göre anlamlı olarak daha yüksekti (sırasıyla p değerleri 0.001 ve 0.011).
Sonuç: Sonuçlarımız, kontrol grubuna göre sklerodermalı hastalarda KİMK'nin daha yüksek olduğunu ve bunun artmış enflamatuar aktivite ile ilişkili olabileceğini göstermektedir.

Keywords

ateroskleroz, enflamasyon, karotis intima-medya kalınlığı, skleroderma

Supporting Institution

Destekleyen kurum bulunmamaktadır.

Assessment of subclinical atherosclerosis with carotid intima-media thickness in patients with scleroderma

Abstract

Aim: Inflammation has an important role in the development of atherosclerosis. The risk of atherosclerosis and its complications is higher for patients with diseases such as systemic lupus erythematosus and rheumatoid arthritis in whom inflammatory activity is high than for healthy individuals. However, several studies have shown conflicting results in patients with scleroderma. In this study, carotid intima-media thickness (CIMT) was compared in patients with scleroderma and a control group.
Methods: Thirty patients diagnosed with scleroderma (mean age 51.3 ± 11.8 years) and 30 healthy volunteers were included in the study. The groups were similar regarding age, gender, and risk factors for atherosclerosis.
Results: There was no statistically significant difference between the groups regarding age, gender, lipid level, hypertension, and diabetes mellitus prevalence (p>0.05). The mean CIMT (scleroderma group: 0.070±0.011, control group: 0.048±0.008, p<0.001) and the maximum CIMT (scleroderma group: 0.076±0.013, control group: 0.054±0.009, p<0.001) were statistically significantly higher in the patients with scleroderma. There was a statistically significant correlation between the mean CIMT and hsCRP (r=0.48, p<0.001); and the mean CIMT and the erythrocyte sedimentation rate (r=0.50, p=0.007) in the scleroderma group. The maximum CIMT and the mean CIMT were significantly higher in patients with diffuse type scleroderma compared to the patients with localized scleroderma (p values 0.001 and 0.011, respectively).
Conclusion: Our results show that CIMT is higher in patients with scleroderma compared to the control group, and this is associated with increased inflammatory activity.

Keywords

atherosclerosis, carotid intima-media thickness, inflammation, scleroderma

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