Erkek Tip 2 Diyabetik Hastalarda Ürik Asit/HDL Oranı ile Monosit/HDL Oranı ve Glisemik Kontrol Arasındaki İlişki

Year 2024, Volume: 34 Issue: 2, 207 - 211, 30.04.2024

Semra Özkan Öztürk , Seval Müzeyyen Ecin

https://doi.org/10.54005/geneltip.1366271

Abstract

Amaç: Tip 2 diabetes mellitus (T2DM) dünya çapında önemli bir sağlık sorunudur Glisemik kontrol kötüleştikçe, hem mikrovasküler hem de makrovasküler komplikasyon riski artar. Bu çalışmada amacımız, tip 2 diyabet tanısı almış erkek bireylerde kan şekeri regülasyonu ile iki farklı parametre arasındaki ilişkiyi araştırmaktır: ürik asit/HDL oranı (UHR) ve monosit/HDL oranı (MHR).
Yöntem: Bu retrospektif araştırmada, tip 2 diyabet tanısı konmuş toplam 166 erkek hasta ve kontrol kohortu olarak 83 sağlıklı yetişkin erkek çalışmaya dahil edilmiştir. Diyabetik erkek katılımcılar eşit olarak iki alt gruba ayrıldı: kan şekeri kontrol altında olmayan grup (7'yi aşan HbA1c seviyeleri, n=83) ve iyi glisemik kontrolü olan grup (7 veya altında HbA1c seviyeleri, n=83). Analizimiz, yüksek yoğunluklu lipoprotein (HDL), trigliserit , düşük yoğunluklu lipoprotein (LDL), ürik asit, nötrofil, lenfosit, monosit, beyaz kan hücresi, hemoglobin ve trombosit seviyeleri dahil olmak üzere çeşitli serum belirteçlerinin değerlendirilmesini kapsamıştır. Ayrıca, UHR, vücut kitle indeksi ve MHR karşılaştırılmıştır.
Bulgular: Çalışma kapsamında tüm katılımcıların kreatinin düzeyleri normaldi. gruplarda yaşlar benzerdi. Trigliserid düzeyleri diyabetik hastalarda sağlıklı grubuna kıyasla belirgin şekilde yüksekti (P<0.001). Buna karşılık, diyabetik hastaların HDL seviyeleri sağlıklı bireylerden daha düşüktü (P=0.002). Serum ürik asit düzeyleri, kan şekeri düzenlenmemiş grupta, kan şekeri iyi düzenlenmiş gruptan ve sağlıklı bireylerden daha düşüktü. (P<0.001). Kan şekeri düzenlenmemiş grupta, kan şekeri iyi düzenlenmiş gruba ve sağlıklı bireylere kıyasla UHR daha düşüktü (P=0.003). Beyaz kan hücreleri, nötrofil ve lenfosit sayıları diyabetik hastalarda sağlıklı gruptan yüksek bulundu (P<0.001, P<0.001 ve P=0.002). Trombosit sayısı ve MHR değerleri kan şekeri regüle olmayan grupta kan şekeri regüle edilen gruba ve sağlıklı bireylere kıyasla daha yüksek bulunmuştur (P=0.007).
Sonuç: Tip 2 diyabetli erkek hastalarda artmış MHR ve azalmış UHR düzeyleri kontrolsüz kan şekeri regülasyonu ile ilişkilidir.

Keywords

ip 2 diyabet, Ürik asit/HDL oranı, Monosit/HDL oranı, HbA1C

The Relationship Between Uric Acid/HDL Ratio and Monocyte/HDL Ratio and Glycemic Control in Male Type 2 Diabetic Patients

Abstract

Background: Type 2 diabetes mellitus (T2DM) is a major health problem worldwide. As glycemic control worsens, the risk of both microvascular and macrovascular complications increases. . The aim of this study was to investigate the relationship between blood glucose regulation and two different parameters: uric acid/HDL ratio (UHR) and monocyte/HDL ratio (MHR) in male subjects with type 2 diabetes.
Methods: In this retrospective study, a total of 166 male patients diagnosed with type 2 diabetes and 83 healthy adult men as a control cohort were included. Diabetic male participants were equally divided into two subgroups: the group with uncontrolled blood glucose (HbA1c levels exceeding 7, n=83) and the group with good glycemic control (HbA1c levels at or below 7, n=83). Our analysis included assessment of several serum markers, including triglyceride, high-density lipoprotein (HDL), uric acid, low-density lipoprotein (LDL), neutrophil, lymphocyte, monocyte, white blood cell, hemoglobin and platelet levels. In addition, uric acid/HDL ratio, body mass index and monocyte/HDL ratio were compared.
Results: Creatinine levels were normal in all study participants and ages were similar in the groups. Triglyceride levels were significantly higher in diabetic patients compared to the healthy group (P<0.001). In contrast, diabetic patients had lower HDL levels than healthy subjects (P=0.002). Serum uric acid levels were lower in the blood glucose unregulated group than in the blood glucose well-regulated group and healthy subjects (P<0.001). UHR was lower in the blood glucose unregulated group compared to the blood glucose well-regulated group and healthy subjects (P=0.003). White blood cell, neutrophil and lymphocyte counts were higher in diabetic patients than in the healthy group (P<0.001, P<0.001, P=0.002). Platelet count and MHR values were higher in the blood glucose-unregulated group compared to the blood glucose-regulated group and healthy subjects (P=0.007).
Conclusion: Increased MHR and decreased UHR levels are associated with uncontrolled blood glucose regulation in male patients with type 2 diabetes.

Keywords

Type 2 diabetes mellitus, Uric acid/HDL ratio, Monocyte/HDL ratio, HbA1C

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