Türk Popülasyonundaki Ülseratif Kolitli Hastalarda TLR1(RS4833095) Gen Polimorfizminin Hastalıkla İlişkisinin Değerlendirilmesi

Year 2024, Volume: 34 Issue: 5, 603 - 608, 31.10.2024

Dilek Çağlayan , Ramazan Dertli , Melek Çağlayan , Mahmut Selman Yıldırım , Hüseyin Ataseven

https://doi.org/10.54005/geneltip.1387463

Abstract

Amaç: Ülseratif Kolit, kolonun mukozal tabakasında tekrarlayan inflamasyon dönemleri ile karakterize olan çok faktörlü bir hastalıktır. Toll benzeri reseptörler (TLR'ler), pro/anti-inflamatuar genlerin uyarılmasında ve adaptif immün yanıtların kontrolünde anahtar rol oynayan transmembran, patern tanıma reseptörleridir. Bu çalışmada TLR1(rs4833095) tek nükleotid polimorfizmi ile ülseratif kolit arasındaki ilişkiyi değerlendirmeyi amaçladık.
Yöntem: Çalışmaya 90 ülseratif kolit hastası ve 90 kişiden oluşan sağlıklı kontrol grubu dahil edildi. Çalışmaya dahil edilen hastaların aldıkları tıbbi tedaviler, laboratuvar verileri, kolonoskopi bulguları, bağırsak dışı bulguları kaydedildi. TLR1(rs4833095) tek nükleotid polimorfizmi RT-PCR yöntemiyle çalışıldı.
Bulgular: Türk toplumunda TLR1(rs4833095) tek nükleotid polimorfizmi olan ülseratif kolit hastalarında ülseratif kolit riskinde artış saptanmadı (p>0,05). Çalışmamızda TLR 1(rs4833095) tek nükleotid polimorfizmi ile hastalığın kolondaki yayılımı, hastalığın şiddeti ve remisyon için gerekli tedavi arasında ilişki saptanmadı(p>0,05).
Sonuç: Türk toplumunda TLR1 (rs4833095) tek nükleotid polimorfizmi değerlendirilmiş ve ülseratif kolitli hastalar ile kontrol grubu arasında anlamlı fark saptanmamıştır.

Keywords

: Ülseratif kolit, toll benzeri reseptörler, inflamatuar barsak hastalığı, tek nükleotid polimorfizmi.

Evaluation of the Relationship between TLR1(RS4833095) Gene Polymorphism and Disease in Patients with Ulcerative Colitis in the Turkish Population

Abstract

Background: Ulcerative Colitis is a multifactorial disease which is characterized by recurrent periods of inflammation in the mucosal layer of the colon. Toll-like receptors (TLRs) are a class of transmembrane pattern recognition receptors that play a key role in the induction of pro/anti-inflammatory genes and in the control of adaptive immune responses. In this study, we aimed to evaluate the relation between TLR1(rs4833095) single nucleotide polymorphism and ulcerative colitis.
Methods: The study included 90 patients with ulcerative colitis and a healthy control group consisting of 90 people. Taken medical treatment, laboratory data, colonoscopy findings, extraintestinal manifestations of patients included in this study were recorded. TLR1(rs4833095) single nucleotide polymorphism was studied with RT-PCR methods.
Results: There was no increased risk for ulcerative colitis in patients with ulcerative colitis who has TLR1(rs4833095) single nucleotide polymorphism in Turkish population (p>0.05). There was no association between TLR 1(rs4833095) single nucleotide polymorphism and the spread of the disease in the colon, severity of disease and treatment required for remission in our study(p>0.05).
Conclusion: In the Turkish population, TLR1 (rs4833095) single nucleotide polymorphism was evaluated and no significant difference was found between the patients with ulcerative colitis and the control group.

Keywords

Ulcerative colitis, toll-like receptors, inflammatory bowel disease, single nucleotide polymorphism.

Supporting Institution

N.E.Ü BAP (Bilimsel Araştırma Projeleri)

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