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Duygudurumla İlişkili ve Duygudurumla İlişkili Olmayan Psikozlarda Nötrofil-Lenfosit Oranının (NLR) Karşılaştırılması

Year 2024, Volume: 34 Issue: 5, 624 - 628, 31.10.2024
https://doi.org/10.54005/geneltip.1413078

Abstract

Amaç: İltihaplı belirteçler, özellikle yükselmiş NLR seviyesi, sistemik iltihabın bilinen göstergeleridir ve psikozu anlamak için pratik araçlar olarak önerilmiştir. Bu çalışmanın birincil amacı, hem duygusal hem de duygusal olmayan psikozda nötrofil, lenfosit ve monosit sayıları ve bunların türetilmiş oranları (NLR, MLR, PLR) dahil olmak üzere kan parametrelerini araştırmaktır. Bu araştırma, psikozun patofizyolojik temellerini aydınlatmada bu biyobelirteçlerin potansiyel rolüne ışık tutmayı ve tanı ve tedavi yaklaşımlarını bilgilendirebilecek içgörüler sunmayı amaçlamaktadır.
Materyaller ve Yöntemler: Bu retrospektif vaka kontrol çalışması, şizofreni (SCH), ilk epizod psikoz (FEP) ve bipolar bozukluk (BD) tanısı konmuş hastalara odaklanmıştır. 2016’dan 2021’e kadar olan dijital tıbbi kayıtlar retrospektif olarak analiz edildi. Çalışmaya toplam 437 hasta dahil edildi ve üç gruba ayrıldı: şizofreni (n = 199), ilk atak psikoz (n = 127) ve bipolar bozukluk (n = 111) ve daha önce psikiyatrik bozukluğu olmayan bireylerden oluşan sağlıklı bir kontrol (HC) grubu (n = 200).
Sonuçlar: Bu çalışmada, şizofreni (SCH) ve bipolar bozukluk (BP) hastalarında nötrofil ve lenfosit sayılarında önemli artışlar gözlemledik. Tersine, monosit sayıları SCH hastalarında kontrol grubuna kıyasla önemli ölçüde azaldı. Özellikle, nötrofil-lenfosit oranı (NLR), ilk atak psikoz (FEP) hastalarında kontrollere kıyasla önemli ölçüde yüksekti. Ayrıca, çalışma grupları arasında monosit-lenfosit oranı (MLR) ve trombosit-lenfosit oranı (PLR) açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (her karşılaştırma için p > 0,05).
Sonuç: Çalışmamız, ilk epizod psikoz (FEP) hastalarında yüksek nötrofil-lenfosit oranına (NLR) dikkat çekerek, NLR’nin psikotik bozuklukların akut ve kronik evrelerini ayırt etme potansiyeli olduğunu göstermektedir. Ancak, bazı önceki çalışmaların aksine, bipolar bozukluk (BP) hastaları ve kontroller arasında anlamlı bir NLR farkı bulamadık. Psikiyatrik bozukluklarda inflamasyon belirteçlerinin rolünü tam olarak anlamak için daha fazla prospektif araştırmaya ihtiyaç vardır.

References

  • Özdin S, Böke Ö. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatry Res. 2019; 271:131-135.
  • Sandberg AA, Steen VM, Torsvik A. Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review. Frontiers in Psychiatry. 2021; 16;12:728990.
  • Fond G, Lançon C, Auquier P, Boyer L. C-reactive protein as a peripheral biomarker in schizophrenia. An updated systematic review. Front Psychiatry. 2018; 23;9:392.
  • Zhu X, Li R, Zhu Y, Zhou J, Huang J, Zhou Y, Tong J, Zhang P, Luo X, Chen S, Li Y, Tian B, Tan SP, Wang Z, Han X, Tian L, Li CSR, Tan YL. Changes in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study. Neuropsychiatr Dis Treat. 2023; 12;19:1597-1604.
  • Karageorgiou V, Milas GP, Michopoulos I. Neutrophil-to-lymphocyte ratio in schizophrenia: A systematic review and meta-analysis. Schizophrenia Research. 2019; 206:4-12.
  • Onur D, Neslihan AK, Samet K. A comparative study of complete blood count inflammatory markers in substance-free acute psychotic disorder and substance-induced psychosis. Early Interv Psychiatry. 2021; 15(6):1522-1530.
  • Çatak Z. Comparison of neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in patients with schizophrenia, bipolar and major depressive disorder. Int J Med Biochem. 2018; 1(3):106-10
  • Zhu X, Zhou J, Zhu Y, Yan F, Han X, Tan Y, Li R. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in schizophrenia. Australas Psychiatry. 2022; 30(1):95-99.
  • Çelik HEA. Assessment of the Inflammatory Markers in Patients with First-episode Psychosis: A Comparative Study. South Clin Istanbul Eurasia. 2023; 34(3):214-219.
  • Kumarasamy C, Sabarimurugan S, Madurantakam RM, Lakhotiya K, Samiappan S, Baxi S, Nachimuthu R, Gothandam KM, Jayaraj R. Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer - A protocol for systematic review and meta-analysis. Medicine (United States). 2019; 98(24):e14834.
  • Chen L, Zeng H, Yang J, Lu Y, Zhang D, Wang J, Kuang C, Zhu S, Wang M, Ma X. Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma. BMC Cancer. 2018; 13;18(1):816.
  • Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31(12):305.
  • Tudurachi BS, Anghel L, Tudurachi A, Sascău RA, Stătescu C. Assessment of Inflammatory Hematological Ratios (NLR, PLR, MLR, LMR and Monocyte/HDL–Cholesterol Ratio) in Acute Myocardial Infarction and Particularities in Young Patients. International Journal of Molecular Sciences. 2023; 21;24(18):14378.
  • Zengin A, Karaca M, Aruǧaslan E, Yildirim E, Karataş MB, Çanga Y, Emre A, Tayyareci G. Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome. J Cardiovasc Thorac Res. 2021; 13(2):125-130.
  • Zeng J, Chen M, Feng Q, Wan H, Wang J, Yang F, Cao H. The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus. Diabetes, Metab Syndr Obes. 2022; 22;15:3617-3626.
  • Varsak N, Aydin M, Eren I. Evaluation of neutrophil-lymphocyte ratio in first-episode psychosis. Klin Psikofarmakol Bul. 2015; 25: Supplement S9-S10.
  • Müller N, Weidinger E, Leitner B, Schwarz MJ. The role of inflammation in schizophrenia. Frontiers in Neuroscience. 2015; 21;9:372.
  • Pandurangi AK, Buckley PF. Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia. Current topics in behavioral neurosciences. 2020; 44:227-244.
  • Wang X, Chen X, Guan X, Li Z. The neutrophil-to-Lymphocyte ratio is associated with clinical symptoms in first-episode medication-naïve patients with schizophrenia. Schizophrenia. 2024; 3;10(1):13.
  • Lu X, Sun Q, Wu L, Liao M, Yao J, Xiu M. The neutrophil-lymphocyte ratio in first-episode medication-naïve patients with schizophrenia: A 12-week longitudinal follow-up study. Prog Neuro-Psychopharmacology Biol Psychiatry. 2024; 131:110959.
  • Llorca-Bofí V, Madero S, Amoretti S, Cuesta MJ, Moreno C, González-Pinto A, Bergé D, Rodriguez-Jimenez R, Roldán A, García-León MÁ, Ibáñez A, Usall J, Contreras F, Mezquida G, García-Rizo C, Berrocoso E, Bernardo M, Bioque M. Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia. Schizophr Res. 2024; 267:24-31.
  • Ayhan MG, Cicek IE, Inanli I, Caliskan AM, Ercan SK, Eren I. Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder. Psychiatry Clin Psychopharmacol. 2017; 27:3, 278-282.
  • Barbosa IG, Machado-Vieira R, Soares JC, Teixeira AL. The immunology of bipolar disorder. Neuroimmunomodulation. 2014; 21(2-3):117-22.

Comparative Study of Inflammatory Markers in Schizophrenia, FirstEpisode Psychosis, and Bipolar Disorder

Year 2024, Volume: 34 Issue: 5, 624 - 628, 31.10.2024
https://doi.org/10.54005/geneltip.1413078

Abstract

Objective: An elevated level of NLR level is defined as an indicator of systemic inflammation, and it is stated that it can be used as an effective tool in navigating psychosis. The aim of the present study is to explore the blood parameters such as neutrophil, lymphocyte, and monocyte and their ratios (NLR, MLR, PLR) in both affective and non-affective psychosis.
Materials and Methods: This is a retrospective case-control study conducted on schizophrenia(Sch), first-episode psychosis(FEP), and bipolar disorder(BD). Digital medical records were retrospectively analyzed between 2016 to 2021. The total number of patients recruited for this study is 437. Patients were divided into 3 groups which are schizophrenia (n:199), FEP (n:127), and Bipolar Disorder (n:111). The healthy control (HC) group (n:200) was selected who had never been diagnosed with any psychiatric disorders.
Results: In this study, no difference was found between the patient groups in terms of substance use (Chi-square= 5.008; p= 0.082), platelet count was lower in SCH patients and no difference was found between the other groups in terms of platelet count. There was no statistical difference between the study groups in terms of lymphocyte, neutrophil, and monocyte counts and their ratios (NLR, MLR, PLR) (p>0.05 for each).
Conclusion: In contrast to the previous findings, we did not show any significant differences in NLR, MLR, and PLR levels in both affective and non-affective psychosis. To better understand the pathophysiology of psychosis, it might be more suitable to conduct a clinical trial with drug-naive FEP patients in a prospective manner.

References

  • Özdin S, Böke Ö. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in different stages of schizophrenia. Psychiatry Res. 2019; 271:131-135.
  • Sandberg AA, Steen VM, Torsvik A. Is Elevated Neutrophil Count and Neutrophil-to-Lymphocyte Ratio a Cause or Consequence of Schizophrenia?—A Scoping Review. Frontiers in Psychiatry. 2021; 16;12:728990.
  • Fond G, Lançon C, Auquier P, Boyer L. C-reactive protein as a peripheral biomarker in schizophrenia. An updated systematic review. Front Psychiatry. 2018; 23;9:392.
  • Zhu X, Li R, Zhu Y, Zhou J, Huang J, Zhou Y, Tong J, Zhang P, Luo X, Chen S, Li Y, Tian B, Tan SP, Wang Z, Han X, Tian L, Li CSR, Tan YL. Changes in Inflammatory Biomarkers in Patients with Schizophrenia: A 3-Year Retrospective Study. Neuropsychiatr Dis Treat. 2023; 12;19:1597-1604.
  • Karageorgiou V, Milas GP, Michopoulos I. Neutrophil-to-lymphocyte ratio in schizophrenia: A systematic review and meta-analysis. Schizophrenia Research. 2019; 206:4-12.
  • Onur D, Neslihan AK, Samet K. A comparative study of complete blood count inflammatory markers in substance-free acute psychotic disorder and substance-induced psychosis. Early Interv Psychiatry. 2021; 15(6):1522-1530.
  • Çatak Z. Comparison of neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in patients with schizophrenia, bipolar and major depressive disorder. Int J Med Biochem. 2018; 1(3):106-10
  • Zhu X, Zhou J, Zhu Y, Yan F, Han X, Tan Y, Li R. Neutrophil/lymphocyte, platelet/lymphocyte and monocyte/lymphocyte ratios in schizophrenia. Australas Psychiatry. 2022; 30(1):95-99.
  • Çelik HEA. Assessment of the Inflammatory Markers in Patients with First-episode Psychosis: A Comparative Study. South Clin Istanbul Eurasia. 2023; 34(3):214-219.
  • Kumarasamy C, Sabarimurugan S, Madurantakam RM, Lakhotiya K, Samiappan S, Baxi S, Nachimuthu R, Gothandam KM, Jayaraj R. Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer - A protocol for systematic review and meta-analysis. Medicine (United States). 2019; 98(24):e14834.
  • Chen L, Zeng H, Yang J, Lu Y, Zhang D, Wang J, Kuang C, Zhu S, Wang M, Ma X. Survival and prognostic analysis of preoperative inflammatory markers in patients undergoing surgical resection for laryngeal squamous cell carcinoma. BMC Cancer. 2018; 13;18(1):816.
  • Ying HQ, Deng QW, He BS, Pan YQ, Wang F, Sun HL, Chen J, Liu X, Wang SK. The prognostic value of preoperative NLR, d-NLR, PLR and LMR for predicting clinical outcome in surgical colorectal cancer patients. Med Oncol. 2014; 31(12):305.
  • Tudurachi BS, Anghel L, Tudurachi A, Sascău RA, Stătescu C. Assessment of Inflammatory Hematological Ratios (NLR, PLR, MLR, LMR and Monocyte/HDL–Cholesterol Ratio) in Acute Myocardial Infarction and Particularities in Young Patients. International Journal of Molecular Sciences. 2023; 21;24(18):14378.
  • Zengin A, Karaca M, Aruǧaslan E, Yildirim E, Karataş MB, Çanga Y, Emre A, Tayyareci G. Performance of neutrophil to lymphocyte ratio for the prediction of long-term morbidity and mortality in coronary slow flow phenomenon patients presented with non-ST segment elevation acute coronary syndrome. J Cardiovasc Thorac Res. 2021; 13(2):125-130.
  • Zeng J, Chen M, Feng Q, Wan H, Wang J, Yang F, Cao H. The Platelet-to-Lymphocyte Ratio Predicts Diabetic Retinopathy in Type 2 Diabetes Mellitus. Diabetes, Metab Syndr Obes. 2022; 22;15:3617-3626.
  • Varsak N, Aydin M, Eren I. Evaluation of neutrophil-lymphocyte ratio in first-episode psychosis. Klin Psikofarmakol Bul. 2015; 25: Supplement S9-S10.
  • Müller N, Weidinger E, Leitner B, Schwarz MJ. The role of inflammation in schizophrenia. Frontiers in Neuroscience. 2015; 21;9:372.
  • Pandurangi AK, Buckley PF. Inflammation, Antipsychotic Drugs, and Evidence for Effectiveness of Anti-inflammatory Agents in Schizophrenia. Current topics in behavioral neurosciences. 2020; 44:227-244.
  • Wang X, Chen X, Guan X, Li Z. The neutrophil-to-Lymphocyte ratio is associated with clinical symptoms in first-episode medication-naïve patients with schizophrenia. Schizophrenia. 2024; 3;10(1):13.
  • Lu X, Sun Q, Wu L, Liao M, Yao J, Xiu M. The neutrophil-lymphocyte ratio in first-episode medication-naïve patients with schizophrenia: A 12-week longitudinal follow-up study. Prog Neuro-Psychopharmacology Biol Psychiatry. 2024; 131:110959.
  • Llorca-Bofí V, Madero S, Amoretti S, Cuesta MJ, Moreno C, González-Pinto A, Bergé D, Rodriguez-Jimenez R, Roldán A, García-León MÁ, Ibáñez A, Usall J, Contreras F, Mezquida G, García-Rizo C, Berrocoso E, Bernardo M, Bioque M. Inflammatory blood cells and ratios at remission for psychosis relapse prediction: A three-year follow-up of a cohort of first episodes of schizophrenia. Schizophr Res. 2024; 267:24-31.
  • Ayhan MG, Cicek IE, Inanli I, Caliskan AM, Ercan SK, Eren I. Neutrophil/lymphocyte and platelet/lymphocyte ratios in all mood states of bipolar disorder. Psychiatry Clin Psychopharmacol. 2017; 27:3, 278-282.
  • Barbosa IG, Machado-Vieira R, Soares JC, Teixeira AL. The immunology of bipolar disorder. Neuroimmunomodulation. 2014; 21(2-3):117-22.
There are 23 citations in total.

Details

Primary Language English
Subjects Psychiatry
Journal Section Original Article
Authors

Beyazit Garip

Begüm Oğur

Şükran Tekin

Öykü İnanç

Early Pub Date October 27, 2024
Publication Date October 31, 2024
Submission Date January 2, 2024
Acceptance Date September 16, 2024
Published in Issue Year 2024 Volume: 34 Issue: 5

Cite

Vancouver Garip B, Oğur B, Tekin Ş, İnanç Ö. Comparative Study of Inflammatory Markers in Schizophrenia, FirstEpisode Psychosis, and Bipolar Disorder. Genel Tıp Derg. 2024;34(5):624-8.

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