Relationship Between Autism Spectrum Disorder And The Brain-Gut Axis

Year 2024, Volume: 34 Issue: 6, 890 - 899, 31.12.2024

Faik Özdengül , Behiye Nur Karakuş Doğan

https://doi.org/10.54005/geneltip.1445907

Abstract

ABSTRACT
All of the microorganisms that live in the intestines are called the microbiota. Metabolites and molecules produced by the microbiota can affect the nervous system and help regulate how the brain works. Communication between the gut and the brain is mediated by the microbiota, the brain-gut axis. There is some evidence to suggest that changes in the microbiota may be associated with autism spectrum disorder (ASD). It is also thought that changes in the microbiota may have an impact on brain function.
Studies show that there is an altered microbiota profile in individuals with ASD compared to the normal population. Individuals with autism may have different gut microbiota communities and reduced overall microbiota diversity. However, whether these changes cause or result from autism has not yet been fully established.
Research into the causes and treatment of ASDs continues, and this area of research has promising potential and may contribute to the development of new treatment approaches for individuals with ASDs in the future.

Keywords

autism spectrum disorder, brain- gut axis, microbiota

Ethical Statement

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Supporting Institution

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Thanks

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Otizm Spektrum Bozukluğu ve Beyin- Bağırsak Aksı ve Mikrobiyota arasındaki İlişki

Abstract

ÖZET
Bağırsaklarda yaşayan mikroorganizmaların tamamına mikrobiyota denir. Mikrobiyotanın ürettiği metabolik ürünler ve moleküller, sinir sistemi üzerinde etkili olabilmekte ve beyin fonksiyonlarını düzenlemektedir. Mikrobiyota, beyin-bağırsak aksı, bağırsaklar ile beyin arasındaki iletişimi sağlamaktadır. Mikrobiyotadaki değişikliklerin otizm spektrum bozukluğu ile ilişkili olabileceğini düşündüren bazı bulgular vardır. Mikrobiyotadaki değişikliklerin beyin fonksiyonları üzerinde etkili olabileceği de düşünülmektedir.
Çalışmalar, otizm spektrum bozukluğu (OSB) olan bireylerde mikrobiyota profilinde normal popülasyona göre değişiklikler olduğunu göstermektedir. Otizmli bireylerde bağırsaklarda farklı mikroorganizma toplulukları bulunabilmekte ve genel olarak mikrobiyota çeşitliliği azalmaktadır. Bununla birlikte, bu değişikliklerin otizmin nedeni mi yoksa sonucu mu olduğu henüz tam olarak belirlenmemiştir.
Otizm spektrum bozukluğunun nedenleri ve tedavisi konusunda araştırmalar halen devam etmekte olup bu alanda yapılan araştırmalar umut verici bir potansiyele sahiptir ve gelecekte otizm spektrum bozukluğu (OSB) olan bireylere yönelik yeni tedavi yaklaşımlarının geliştirilmesine katkıda bulunacağı düşünülmektedir.

Keywords

otizm spektrum bozukluğu, beyin bağırsak aksı, mikrobiyota

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