Yaşlı Hastalarda Post-COVID Sendromunun Bir Diğer Yüzü: Sistemik Enflamasyona Bağlı Artan Kırılganlık

Year 2023, Volume: 6 Issue: 2, 114 - 123, 31.08.2023

Gülbahar Darılmaz Yüce Funda Salgür Samra Kamilova Özgün Çiçek Matin Iskandarov Meriç Yavuz Çolak Gaye Ulubay M. Şule Akçay

https://doi.org/10.47141/geriatrik.1276791

Abstract

Amaç: COVID-19’un yaşlı yetişkinlerde uzun süreli morbidite ve mortalite yaratan bir durum olduğu bilinmektedir. COVID-19 ve kırılganlık ilişkisi hakkında henüz yeterli bilgi yoktur. Çalışmamızda COVID-19’un uzun vadeli etkileri arasında sayılabilecek bir durum olan kırılganlığı arttırıp arttırmadığını araştırdık.

Gereç ve Yöntemler: Çalışmaya Başkent Üniversitesi Tıp Fakültesi Hastanesi COVID-19 İzolasyon Servisi’nde yatan 65 yaş üstü, COVID-19 PCR testi pozitif olan 73 hasta dahil edildi. Hastalar hafif-orta pnömoni, ağır pnömoni ve yoğun bakım ünitesine yatış gerektiren ciddi pnömoni olarak kategorize edildi. Hastalara yatışının ilk gününde FRAIL Frailty ölçeği uygulandı. Taburculuk sonrası 3. ay kontrolünde tekrar FRAIL Frailty ölçeği uygulandı. Hastaneye yatışın ilk günü ve taburculuk sonrası 3. ay kontrol FRAIL indeksleri karşılaştırıldı.

Bulgular: Çalışmamıza katılan hastaların %58,9’u erkek, %41,1’i kadındı. Ortalama yaşları 77,48±7,68 idi. Ortalama FRAIL skoru yatışın ilk günü 1,34±0,12 iken taburculuk sonrası 2,24±0,12 idi. İlk ve son FRAIL skorları arasındaki ortalama değişim %60,3 idi ve istatistiksel olarak anlamlıydı (p<0,001). FRAIL skorundaki değişim en fazla %95 ile yoğun bakım grubunda oldu (p<0,001).

Sonuç: COVID-19 sistemik inflamasyonu arttırarak kırılganlığın artmasına neden olur. Yaşlı hastalar COVID-19 sırasında ve sonrasında kırılganlık açısından değerlendirilmelidir.

Keywords

COVID-19, uzun süreli COVID-19, yaşlı, kırılgan yaşlı, hastane yatışı

Supporting Institution

Bu çalışma Başkent Üniversitesi Araştırma Fonu tarafınca desteklenmiştir.

Project Number

KA22/167

Another Face of the Post-COVID Syndrome in Elderly Patients: Increased Frailty Due to Systemic Inflammation

Abstract

Aim: COVID-19 is known to be a condition that creates long-term morbidity and mortality in older adults. There is not enough information yet about the relationship between COVID-19 and frailty. In our study, we investigated whether COVID-19 increases frailty, a condition that can be counted among its long-term effects.

Materials and Methods: The study included 73 patients over the age of 65 who were hospitalized in the Başkent University Medical Faculty Hospital COVID-19 Isolation Service, with positive COVID-19 PCR test. Patients were categorized as mild-moderate, severe, and critical pneumonia requiring intensive care unit admission. The FRAIL Frailty scale was applied to the patients on the first day of hospitalization. The FRAIL Frailty scale was applied again at the 3rd month follow-up after discharge. FRAIL index were compared on the first day of hospitalization and 3 months after discharge due to COVID-19.

Results: 58.9% of the patients participating in our study were male and 41.1% were female. Their mean age was 77.48±7.68 years. The mean FRAIL score was 1.34±0.12 on the first day of hospitalization and 2.24±0.12 after discharge. The mean change in FRAIL score between the first day of hospitalization and after discharge was 60.3% and was statistically significant (p<0.001). The change was the highest in the intensive care unit group, with 95% (p<0.001).

Conclusion: COVID-19 increases systemic inflammation, leading to increased frailty. Elderly patients should be evaluated for frailty during and after COVID-19.

Keywords

COVID-19,, long COVID, aged, frail elderly, hospitalization

Project Number

KA22/167

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