Review
BibTex RIS Cite

Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri

Year 2024, Volume: 7 Issue: 3, 240 - 252, 31.12.2024
https://doi.org/10.47141/geriatrik.1454707

Abstract

Günümüzde, dünya nüfusunda geriatrik bireylerin oranı hızla artmaktadır. Bu demografik değişim sağlık alanında da önemli etkiler yaratmaktadır. Özellikle diş hekimliği pratiğinde geriatrik bireylerin sayısındaki artış, geriatrik hastalıkların ve buna bağlı ağız sağlığı sorunlarının insidansında bir artışa neden olmaktadır. Geriatrik bireylerde ağız sağlığının önemi giderek daha fazla vurgulanmaktadır, çünkü ağız sağlığı genel sağlık ve konforun bir göstergesi olarak kabul edilmektedir.
Yaşlı popülasyonda sık görülen sistemik hastalıkların ağız sağlığı üzerinde de ciddi etkileri olduğu bilinmektedir. Ağız sağlığının, özellikle de diş etleri ve dişlerin durumunun, birçok sistemik hastalığın risk faktörleri arasında yer aldığı belirtilmektedir. Bu nedenle, geriatrik bireylerde sistemik hastalıkların ve ağız sağlığının birbirini etkileyen dinamiklerinin iyi anlaşılması gerekmektedir.
Ayrıca, geriatrik bireylerin sıklıkla kullandığı ilaçlar ve bu ilaçların yan etkileri, diş hekimlerinin dikkate alması gereken önemli bir husustur. Geriatrik bireylerde farmakokinetik ve farmakodinamik süreçlerin gençlerden farklıdır. Bu nedenle, diş hekimlerinin geriatrik bireylerin tedavisinde ilaç etkileşimleri ve yan etkileri konusunda dikkatli olmaları gerekmektedir.
Son olarak, geriatrik hasta grubundaki ilaç kullanımı ve etkileri üzerine yapılan araştırmalar, diş hekimlerinin bu alandaki bilgisini güncel tutmalarını sağlamaktadır. Bu bilgiler, tanı koyma ve olası komplikasyonlara müdahale etme konusunda diş hekimlerine rehberlik ederken, aynı zamanda geriatrik bireylerde daha etkili ve güvenli tedavi planları oluşturmalarına yardımcı olur. Bu bağlamda, PubMed, Google Akademik ve Web of Science gibi veri tabanlarından elde edilen güncel literatür, diş hekimlerinin bu alandaki bilgi birikimini artırmak için önemli bir kaynaktır. Bu nedenle, küresel olarak yaşlanan nüfus ve sıklıkla kullanılan ilaçlar arasındaki ilişkiyi anlamak ve bu ilaçların ağız sağlığı üzerindeki etkilerini değerlendirmek için bir derleme hazırlama ihtiyacı doğmuştur.

References

  • Dünya Sağlık Örgütü.Yaşlanma ve Sağlık. https://www.who.int/news-room/fact-sheets/detail/ageingandhealth. Erişim tarihi: 14.02.2024
  • Birleşmiş Milletler. Dünya Nüfusunun Yaşlanması 2019. https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/files/documents/2020/Jan/un_2019_worldpopulationageing_report.pdf. Erişim tarihi: 14.02.2024
  • https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2023-53710#:~:text=T%C3%9C%C4%B0K%20Kurumsal&text=Ya%C5%9Fl%C4%B1%20n%C3%BCfus%20olarak%20kabul%20edilen,722%20bin%20806%20ki%C5%9Fi%20oldu. Erişim tarihi: 05.08.2024
  • Kirkwood TB. Understanding ageing from an evolutionary perspective. J Intern Med. 2008; 263(2).: 117-27.
  • Akdeniz M, Kavukcu E, Teksan A. Yaşlanmaya bağlı fizyolojik değişiklikler ve kliniğe yansımaları. İzbırak G, editör. Birinci Basamakta Yaşlı Sağlığı. Ankara: Türkiye Klinikleri; 2019; 1: 1-15.
  • Aksüllü NŞ. Kurumda ve Evde Yaşayan Yaşlı Bireylerin Algılanan Sosyal Destek Faktörleri ile Depresyon Arasındaki İlişki. Cumhuriyet Üniversitesi/Sağlık Bilimleri Enstitüsü, Sivas. 2002: 8: 84-102.
  • Lee SB, Hun Oh J, Park JH, et al. Clinical and Experimental Emergency Medicine, 2018; 5(4).: 249–255.
  • Karakovan A. Yaşlı sağlığı ve bakım 1. Baskı. Ankara: Akademisyen Tıp Kitapevi; 2014: 4-16.
  • Brunton P. Prevention in the older dentate patient, Br Dent J , 2003; 195(5).: 237-241.
  • Wyatt CC, Kawato T. Changes in Oral Health and Treatment Needs for Elderly, Essential Dental Knowledge, 2019; 85: 1-3.
  • DuMontier C, Sedrak MS, Soo WK, et. al. Arti Hurria and the progress in integrating the geriatric assessment into oncolo-gy: Young International Society of Geriatric Oncology review paper. J Geriatr Oncol. 2020; 11(2).: 203-211.
  • Wilkinson I, Harper A. Comprehensive geriatric assessment, rehabilitation and discharge planning. Medicine, 2021; 49(1).; 10-16.
  • Andres TM, McGrane T, McEvoy MD, Allen BFS. Geriatric Pharmacology: An Update. Anesthesiol Clin. 2019; 37(3).: 475-492.
  • Sofulu F, Karadakovan A. Geriatrik oranlarının Polifarmasi ve İlaç Kullanımı ile İlgili Bilgi ve Uygulamalarının Değer-lendirilmesi. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. Eylül 2022;7(3).:529-533.
  • Ștefan CS, Nechita A, Dragostin OM, Fulga A, Lisă EL, Vatcu R, Dragostin I, Velicescu C, Fulga I. Drugs Associated with Ad-verse Effects in Vulnerable Groups of Patients. Clin Pract. 2024;14(3).:1010-1020.
  • Drugs for hypertension. Med Lett Drugs Ther. 2024; 66(1703).:81-88.
  • Sirker A, Missouris CG, MacGregor GA. Dihydropyridine calcium channel blockers and peripheral side effects. J Hum Hy-pertens. 2001;15(10).:745-6.
  • Aubertin MA., Horbelt C., Wasson W., Woods M. Medication use in geriatric populations: dental implications of frequently prescribed medications. Gen Dent. 2010;58(2).:100-109.
  • Shepler SA, Grogan TA, Pater KS. Keep your older patients out of medication trouble. Nursing 2006; 36(9).: 44-7.
  • Kayaalp O. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. 11.Baskı, Ankara: Hacettepe-Taş Kitapçılık, 2005: 1-8
  • McInerney BE, Cross AJ, Alderman CP, et al. Signs and Symptoms of Psychotropic Adverse Drug Events to Monitor in Resi-dents of Long-Term Care Facilities. J Am Med Dir Assoc. 2024;25(9).:105-118.
  • Mathews M, Mathews M, Mathews J. Recognition and treatment of depression in the elderly. Primary Psychiatry 2004; 11(2).: 33-37.
  • Dağdelen S, Erbaş T. Diabetes Mellitus. İçinde: Temel Geriatri Gökçe-Kutsal Y, Aslan D, Editörler, 1. Baskı, Ankara: Öncü Basımevi, 2007: 801-805.
  • Liu Za Zhi ZZ. Expert consensus on safety management of bone-modifying agents 2024;46(7).:637-645.
  • Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonates-induced exposed bone (osteonecrosis / osteopetrosis). of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005; 63: 1567-75.
  • Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, et al. Osteonecrosis of the jaw in cancer after treatment bisphosphonates: incidence and risk factors. J Clin Oncol 2005; 23: 8580-7.
  • Seymour RA, Rudralingham M. Oral and Dental Adverse Drug Reactions. Periodontology 2000 2008; 46: 9-26.
  • Wolff A, Joshi RK, Ekstrom J, et. al. A Guide to Medications Causing Salivary Gland Dysfunction, Xerostomia, and Subjec-tive Sialorrhea: A Systematic Review Under the Sponsorship of the VI World Workshop on Oral Medicine. Drugs RD. 2017; 17: 1-28.
  • Vigarios E, Epstein JB, Sibaud V: Oral Mucosal Changes Induced by Anticancer Targeted Therapies and Immune Check-point Inhibitors. Supportive Care in Cancer. 2017; 25: 1713-1739.
  • Scully C. Drug effects on salivary glands; dry mouth. Oral Dis. 2003; 9: 165-176.
  • Einhorn OM, Georgiou K, Tompa A. Salivary dysfunction caused by medication usage. Physiol Int. 2020;107(2).:195-208.
  • Ouanounou A. Xerostomia in the Geriatric Patient: Causes, Oral Manifestations, and Treatment. Compend Contin Educ Dent. 2016;37(5).:306-312.
  • Donovan T. Maust MD, Solway MSE. Prescription and Nonprescription Sleep Product Use Among Older Adults in the Unit-ed States. American Journal of Geriatric Psychiatry. 2019; 27(1).: 32-41.
  • Meurman JH, Murtomaa H. Oral discomfort and health behavior of patients with typical vs. atypical antipsychotic drugs. Front Psychiatry. 2024;15:1420010.
  • Thomson WM, Slade GD, Spencer AJ. Dental caries experience and use of prescription medication amongst people age 60+ in South Australia. Gerodontology. 1995: 12: 104–110.
  • Janket SJ, Jones JA, Rich S, et al. Xerostomic medications and oral health: the Veterans Dental Study (part I).. Gerodontol-ogy. 2003: 20: 41–49.
  • Seymour RA, Rudralingham M. Oral and Dental Adverse Drug Reactions. Periodontology 2000. 2008; 46: 9-26.
  • Amiri S, Nikvarz N, Sabouri S. Drug-induced Tongue Disorders: A Comprehensive Literature Review. Curr Drug Saf. 2024.
  • Henkin RI. Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treat-ment of sensory receptor dysfunction. Drug Safety, 1994; 11: 318-327.
  • Scully C, Bagan J. Oral mucosal diseases: erythema multiforme. Br J Oral Maxillofac Surg. 2008; 46(2).: 90-95.
  • Li D, Li J, Li C, et. al. The association of thyroid disease and oral lichen planus: a literature review and meta-analysis. Front Endocrinol (Lausanne)., 2017; 8: 310.
  • Israeli ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology. Ann Intern Med. 1992; 117: 234-42.
  • Bakker MH, Vissink A, de Baat C, et al. Medicaments and oral healthcare 6. Oral side effects of -medications commonly used by older people. Ned Tijdschr Tandheelkd. 2017;124(12).:645-652.
  • Lafzi A, Farahani RM, Shoja MA. Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal. 2006; 11(6).: E480-E482.
  • Boulinguez S, Reix S, Bedane C, et. al. Role of drug exposure in aphthous ulcers: a case-control study. Br J Dermatol. 2000; 143: 1261-1265.
  • Goffin E, Pochet JM, Lejuste P, et al. Aphtous ulcers of the mouth associated with losartan. Clin Nephrol. 1998; 50: 197.
  • Lerman MA, Karimbux N, Guze KA, et al. Pigmentation of the hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol En-dod. 2009; 107: 8-12.
  • Arora B, Kumar L, Sharma A, et al. Pigmentary changes in chronic myeloid leukemia patients treated with imatinib mesyl-ate. Ann Oncol. 2004; 15: 358-359.
  • Nakib N, Ashrafi SS. Drug-induced gingival overgrowth. Dis Mon. 2011; 57(4).: 225-230.
  • Al-Mohaya M, Treister N, Al-Khadra O, et al. Calcineurin inhibitor-associated oral inflammatory polyps after transplanta-tion. J Oral Pathol Med 2007; 36: 570-574.
  • Ruggiero SL, Dodson TB, Fantasia J, et al. American Association of Oral and Maxillofacial Surgeons position paper on med-ication-related osteonecrosis of the jaw: 2014 update. J Oral Maxillofac Surg 2014; 72: 1938-1956.
  • Christodoulou C, Pervena A, Klouvas G, et. al. Combination of bisphosphonates and antiangiogenic factors induces oste-onecrosis of the jaw more frequently than bisphosphonates alone. Oncology 2009; 76: 209-211.
  • Zarringhalam P, Brizman E, Shakib K. Medication-related osteonecrosis of the jaw associated with aflibercept. Br J Oral Maxillofac Surg. 2017; 55: 314-315.
  • Nicolatou-Galitis O, Kouri M, Papadopoulou E, et. al. Osteonecrosis of the jaw related to non-antiresorptive medications: a systematic review. Support Care Cancer 2019; 27: 383-394.
  • Ruiz-Mojica CA, Brizuela M. Viral Infections of the Oral Mucosa. In: StatPearls. Treasure Island (FL).: StatPearls Publishing; March 19, 2023.
  • Bongartz T, Sutton AJ, Sweeting MJ, et. al.: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious in-fections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295: 2275-2285.
  • Salvana EM, Salata RA. Infectious complications associated with monoclonal antibodies and related small molecules. Clin Microbiol Rev. 2009; 22: 274-290.

The Oral Side Effects of Medications Used in Geriatric Patients

Year 2024, Volume: 7 Issue: 3, 240 - 252, 31.12.2024
https://doi.org/10.47141/geriatrik.1454707

Abstract

The proportion of geriatric individuals in the world population is rapidly increasing, leading to significant implications in the healthcare domain. Particularly in the field of dentistry, the rising number of geriatric individuals contributes to an increased incidence of geriatric diseases and associated oral health issues. The importance of oral health in the geriatric population is increasingly emphasized, as oral health is recognized as an indicator of overall health and well-being.
It is well-established that systemic diseases commonly observed in the elderly population have serious effects on oral health. The condition of the gums and teeth, especially, is noted as a risk factor for many systemic diseases. Therefore, it is crucial to understand the dynamics of systemic diseases and oral health in geriatric individuals and their interplay.
Moreover, the medications frequently used by geriatric individuals and their side effects are significant considerations for dental practitioners. Pharmacokinetic and pharmacodynamic processes differ in geriatric individuals compared to younger populations. Hence, dental practitioners need to exercise caution regarding drug interactions and side effects when treating geriatric patients.
Furthermore, research on medication use and its effects in the geriatric patient group serves to keep dental practitioners updated in this field. Such information not only guides dental practitioners in diagnosis and intervention for potential complications but also assists in the formulation of more effective and safe treatment plans for geriatric individuals. In this context, contemporary literature obtained from databases like PubMed, Google Scholar, and Web of Science serves as a crucial source for enhancing dental practitioners’ knowledge in this area. Therefore, there is a need to compile a review to understand the relationship between the globally aging population and commonly used medications and evaluate the effects of these medications on oral health.

References

  • Dünya Sağlık Örgütü.Yaşlanma ve Sağlık. https://www.who.int/news-room/fact-sheets/detail/ageingandhealth. Erişim tarihi: 14.02.2024
  • Birleşmiş Milletler. Dünya Nüfusunun Yaşlanması 2019. https://www.un.org/development/desa/pd/sites/www.un.org.development.desa.pd/files/files/documents/2020/Jan/un_2019_worldpopulationageing_report.pdf. Erişim tarihi: 14.02.2024
  • https://data.tuik.gov.tr/Bulten/Index?p=Istatistiklerle-Yaslilar-2023-53710#:~:text=T%C3%9C%C4%B0K%20Kurumsal&text=Ya%C5%9Fl%C4%B1%20n%C3%BCfus%20olarak%20kabul%20edilen,722%20bin%20806%20ki%C5%9Fi%20oldu. Erişim tarihi: 05.08.2024
  • Kirkwood TB. Understanding ageing from an evolutionary perspective. J Intern Med. 2008; 263(2).: 117-27.
  • Akdeniz M, Kavukcu E, Teksan A. Yaşlanmaya bağlı fizyolojik değişiklikler ve kliniğe yansımaları. İzbırak G, editör. Birinci Basamakta Yaşlı Sağlığı. Ankara: Türkiye Klinikleri; 2019; 1: 1-15.
  • Aksüllü NŞ. Kurumda ve Evde Yaşayan Yaşlı Bireylerin Algılanan Sosyal Destek Faktörleri ile Depresyon Arasındaki İlişki. Cumhuriyet Üniversitesi/Sağlık Bilimleri Enstitüsü, Sivas. 2002: 8: 84-102.
  • Lee SB, Hun Oh J, Park JH, et al. Clinical and Experimental Emergency Medicine, 2018; 5(4).: 249–255.
  • Karakovan A. Yaşlı sağlığı ve bakım 1. Baskı. Ankara: Akademisyen Tıp Kitapevi; 2014: 4-16.
  • Brunton P. Prevention in the older dentate patient, Br Dent J , 2003; 195(5).: 237-241.
  • Wyatt CC, Kawato T. Changes in Oral Health and Treatment Needs for Elderly, Essential Dental Knowledge, 2019; 85: 1-3.
  • DuMontier C, Sedrak MS, Soo WK, et. al. Arti Hurria and the progress in integrating the geriatric assessment into oncolo-gy: Young International Society of Geriatric Oncology review paper. J Geriatr Oncol. 2020; 11(2).: 203-211.
  • Wilkinson I, Harper A. Comprehensive geriatric assessment, rehabilitation and discharge planning. Medicine, 2021; 49(1).; 10-16.
  • Andres TM, McGrane T, McEvoy MD, Allen BFS. Geriatric Pharmacology: An Update. Anesthesiol Clin. 2019; 37(3).: 475-492.
  • Sofulu F, Karadakovan A. Geriatrik oranlarının Polifarmasi ve İlaç Kullanımı ile İlgili Bilgi ve Uygulamalarının Değer-lendirilmesi. İzmir Katip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi. Eylül 2022;7(3).:529-533.
  • Ștefan CS, Nechita A, Dragostin OM, Fulga A, Lisă EL, Vatcu R, Dragostin I, Velicescu C, Fulga I. Drugs Associated with Ad-verse Effects in Vulnerable Groups of Patients. Clin Pract. 2024;14(3).:1010-1020.
  • Drugs for hypertension. Med Lett Drugs Ther. 2024; 66(1703).:81-88.
  • Sirker A, Missouris CG, MacGregor GA. Dihydropyridine calcium channel blockers and peripheral side effects. J Hum Hy-pertens. 2001;15(10).:745-6.
  • Aubertin MA., Horbelt C., Wasson W., Woods M. Medication use in geriatric populations: dental implications of frequently prescribed medications. Gen Dent. 2010;58(2).:100-109.
  • Shepler SA, Grogan TA, Pater KS. Keep your older patients out of medication trouble. Nursing 2006; 36(9).: 44-7.
  • Kayaalp O. Rasyonel Tedavi Yönünden Tıbbi Farmakoloji. 11.Baskı, Ankara: Hacettepe-Taş Kitapçılık, 2005: 1-8
  • McInerney BE, Cross AJ, Alderman CP, et al. Signs and Symptoms of Psychotropic Adverse Drug Events to Monitor in Resi-dents of Long-Term Care Facilities. J Am Med Dir Assoc. 2024;25(9).:105-118.
  • Mathews M, Mathews M, Mathews J. Recognition and treatment of depression in the elderly. Primary Psychiatry 2004; 11(2).: 33-37.
  • Dağdelen S, Erbaş T. Diabetes Mellitus. İçinde: Temel Geriatri Gökçe-Kutsal Y, Aslan D, Editörler, 1. Baskı, Ankara: Öncü Basımevi, 2007: 801-805.
  • Liu Za Zhi ZZ. Expert consensus on safety management of bone-modifying agents 2024;46(7).:637-645.
  • Marx RE, Sawatari Y, Fortin M, Broumand V. Bisphosphonates-induced exposed bone (osteonecrosis / osteopetrosis). of the jaws: risk factors, recognition, prevention, and treatment. J Oral Maxillofac Surg 2005; 63: 1567-75.
  • Bamias A, Kastritis E, Bamia C, Moulopoulos LA, Melakopoulos I, Bozas G, et al. Osteonecrosis of the jaw in cancer after treatment bisphosphonates: incidence and risk factors. J Clin Oncol 2005; 23: 8580-7.
  • Seymour RA, Rudralingham M. Oral and Dental Adverse Drug Reactions. Periodontology 2000 2008; 46: 9-26.
  • Wolff A, Joshi RK, Ekstrom J, et. al. A Guide to Medications Causing Salivary Gland Dysfunction, Xerostomia, and Subjec-tive Sialorrhea: A Systematic Review Under the Sponsorship of the VI World Workshop on Oral Medicine. Drugs RD. 2017; 17: 1-28.
  • Vigarios E, Epstein JB, Sibaud V: Oral Mucosal Changes Induced by Anticancer Targeted Therapies and Immune Check-point Inhibitors. Supportive Care in Cancer. 2017; 25: 1713-1739.
  • Scully C. Drug effects on salivary glands; dry mouth. Oral Dis. 2003; 9: 165-176.
  • Einhorn OM, Georgiou K, Tompa A. Salivary dysfunction caused by medication usage. Physiol Int. 2020;107(2).:195-208.
  • Ouanounou A. Xerostomia in the Geriatric Patient: Causes, Oral Manifestations, and Treatment. Compend Contin Educ Dent. 2016;37(5).:306-312.
  • Donovan T. Maust MD, Solway MSE. Prescription and Nonprescription Sleep Product Use Among Older Adults in the Unit-ed States. American Journal of Geriatric Psychiatry. 2019; 27(1).: 32-41.
  • Meurman JH, Murtomaa H. Oral discomfort and health behavior of patients with typical vs. atypical antipsychotic drugs. Front Psychiatry. 2024;15:1420010.
  • Thomson WM, Slade GD, Spencer AJ. Dental caries experience and use of prescription medication amongst people age 60+ in South Australia. Gerodontology. 1995: 12: 104–110.
  • Janket SJ, Jones JA, Rich S, et al. Xerostomic medications and oral health: the Veterans Dental Study (part I).. Gerodontol-ogy. 2003: 20: 41–49.
  • Seymour RA, Rudralingham M. Oral and Dental Adverse Drug Reactions. Periodontology 2000. 2008; 46: 9-26.
  • Amiri S, Nikvarz N, Sabouri S. Drug-induced Tongue Disorders: A Comprehensive Literature Review. Curr Drug Saf. 2024.
  • Henkin RI. Drug-induced taste and smell disorders. Incidence, mechanisms and management related primarily to treat-ment of sensory receptor dysfunction. Drug Safety, 1994; 11: 318-327.
  • Scully C, Bagan J. Oral mucosal diseases: erythema multiforme. Br J Oral Maxillofac Surg. 2008; 46(2).: 90-95.
  • Li D, Li J, Li C, et. al. The association of thyroid disease and oral lichen planus: a literature review and meta-analysis. Front Endocrinol (Lausanne)., 2017; 8: 310.
  • Israeli ZH, Hall WD. Cough and angioneurotic edema associated with angiotensin-converting enzyme inhibitor therapy: a review of the literature and pathophysiology. Ann Intern Med. 1992; 117: 234-42.
  • Bakker MH, Vissink A, de Baat C, et al. Medicaments and oral healthcare 6. Oral side effects of -medications commonly used by older people. Ned Tijdschr Tandheelkd. 2017;124(12).:645-652.
  • Lafzi A, Farahani RM, Shoja MA. Amlodipine-induced gingival hyperplasia. Med Oral Patol Oral Cir Bucal. 2006; 11(6).: E480-E482.
  • Boulinguez S, Reix S, Bedane C, et. al. Role of drug exposure in aphthous ulcers: a case-control study. Br J Dermatol. 2000; 143: 1261-1265.
  • Goffin E, Pochet JM, Lejuste P, et al. Aphtous ulcers of the mouth associated with losartan. Clin Nephrol. 1998; 50: 197.
  • Lerman MA, Karimbux N, Guze KA, et al. Pigmentation of the hard palate. Oral Surg Oral Med Oral Pathol Oral Radiol En-dod. 2009; 107: 8-12.
  • Arora B, Kumar L, Sharma A, et al. Pigmentary changes in chronic myeloid leukemia patients treated with imatinib mesyl-ate. Ann Oncol. 2004; 15: 358-359.
  • Nakib N, Ashrafi SS. Drug-induced gingival overgrowth. Dis Mon. 2011; 57(4).: 225-230.
  • Al-Mohaya M, Treister N, Al-Khadra O, et al. Calcineurin inhibitor-associated oral inflammatory polyps after transplanta-tion. J Oral Pathol Med 2007; 36: 570-574.
  • Ruggiero SL, Dodson TB, Fantasia J, et al. American Association of Oral and Maxillofacial Surgeons position paper on med-ication-related osteonecrosis of the jaw: 2014 update. J Oral Maxillofac Surg 2014; 72: 1938-1956.
  • Christodoulou C, Pervena A, Klouvas G, et. al. Combination of bisphosphonates and antiangiogenic factors induces oste-onecrosis of the jaw more frequently than bisphosphonates alone. Oncology 2009; 76: 209-211.
  • Zarringhalam P, Brizman E, Shakib K. Medication-related osteonecrosis of the jaw associated with aflibercept. Br J Oral Maxillofac Surg. 2017; 55: 314-315.
  • Nicolatou-Galitis O, Kouri M, Papadopoulou E, et. al. Osteonecrosis of the jaw related to non-antiresorptive medications: a systematic review. Support Care Cancer 2019; 27: 383-394.
  • Ruiz-Mojica CA, Brizuela M. Viral Infections of the Oral Mucosa. In: StatPearls. Treasure Island (FL).: StatPearls Publishing; March 19, 2023.
  • Bongartz T, Sutton AJ, Sweeting MJ, et. al.: Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious in-fections and malignancies: systematic review and meta-analysis of rare harmful effects in randomized controlled trials. JAMA 2006; 295: 2275-2285.
  • Salvana EM, Salata RA. Infectious complications associated with monoclonal antibodies and related small molecules. Clin Microbiol Rev. 2009; 22: 274-290.
There are 57 citations in total.

Details

Primary Language Turkish
Subjects Geriatrics and Gerontology
Journal Section Review
Authors

Fulya Karaduman 0009-0007-6237-3100

Funda Bayindir 0000-0001-5699-2879

Publication Date December 31, 2024
Submission Date March 18, 2024
Acceptance Date September 2, 2024
Published in Issue Year 2024 Volume: 7 Issue: 3

Cite

APA Karaduman, F., & Bayindir, F. (2024). Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri. Geriatrik Bilimler Dergisi, 7(3), 240-252. https://doi.org/10.47141/geriatrik.1454707
AMA Karaduman F, Bayindir F. Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri. JoGS. December 2024;7(3):240-252. doi:10.47141/geriatrik.1454707
Chicago Karaduman, Fulya, and Funda Bayindir. “Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri”. Geriatrik Bilimler Dergisi 7, no. 3 (December 2024): 240-52. https://doi.org/10.47141/geriatrik.1454707.
EndNote Karaduman F, Bayindir F (December 1, 2024) Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri. Geriatrik Bilimler Dergisi 7 3 240–252.
IEEE F. Karaduman and F. Bayindir, “Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri”, JoGS, vol. 7, no. 3, pp. 240–252, 2024, doi: 10.47141/geriatrik.1454707.
ISNAD Karaduman, Fulya - Bayindir, Funda. “Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri”. Geriatrik Bilimler Dergisi 7/3 (December 2024), 240-252. https://doi.org/10.47141/geriatrik.1454707.
JAMA Karaduman F, Bayindir F. Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri. JoGS. 2024;7:240–252.
MLA Karaduman, Fulya and Funda Bayindir. “Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri”. Geriatrik Bilimler Dergisi, vol. 7, no. 3, 2024, pp. 240-52, doi:10.47141/geriatrik.1454707.
Vancouver Karaduman F, Bayindir F. Geriatrik Hastalarda Kullanılan İlaçların Ağız İçi Yan Etkileri. JoGS. 2024;7(3):240-52.

Creative Commons Lisansı

Articles published in this journal are licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.


The Journal of Geriatric Science is indexed in Turkey Citation Index, Turkish MEDLINE, Asos Index, Scilit, EuroPub, Index Copernicus International - Journals Master List since September 2022 and ULAKBIM TR-INDEX since 2023 issues.

31219     | download   | 24435    |        |    24370   

24026    |    17423    |    scholar_logo_64dp.png     |     24050