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MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER

Year 2025, Volume: 50 Issue: 4, 629 - 643, 10.08.2025
https://doi.org/10.15237/gida.GD25052

Abstract

Mikotoksinler, halk sağlığı üzerinde oluşturdukları tehdit ve ekonomilere olan olumsuz etkileri nedeniyle dünya çapında önemli bir sorun olarak kabul edilmektedir. Bu nedenle, gıdalarda mikotoksinlerin önlenmesi, kısmen azaltılması veya tamamen ortadan kaldırılmasına yönelik çalışmalar önem taşımaktadır. Gıdalardaki mikotoksinleri engellemek için uygulanan ısıl işlem, fermantasyon ve ışınlama gibi bazı endüstriyel ve evsel işlemler incelendiğinde, bu işlemlerin mikotoksinlerin tamamen uzaklaştırılmasında yetersiz kaldığı gözlemlenmiştir. Bu sebeple son yıllarda mikotoksinlerin kontrol altına alınabilmesi amacıyla tamamlayıcı stratejiler ve yenilikçi yöntemlerin geliştirilmesine odaklanılmıştır. Mikotoksin detoksifikasyonu için fiziksel (ışınlama, soğuk plazma, yüksek basınç, darbeli elektrik alanları), kimyasal (amonyak, kitosan, ozon) ve biyolojik (laktik asit bakterileri, probiyotikler) birçok yöntem kullanılmaktadır. Fiziksel ve kimyasal yöntemlerle karşılaştırıldığında, biyolojik yöntemlerle detoksifikasyon süreçleri, gıda ürünlerinin besin değerlerinde daha az kayba neden oldukları için en umut verici yaklaşım olarak değerlendirilmektedir.

References

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  • Akbulut, İ. (2023). Sultaniye cinsi kuru üzümde bulunan Okratoksin (OTA) detoksifikasyonunda soğuk plazma teknolojisinin kullanımı ve kalite özelliklerinin incelenmesi. Ege Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisliği Anabilim Dalı Yüksek Lisans Tezi, İzmir Türkiye, 150 s.
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PHYSICAL, CHEMICAL AND BIOLOGICAL METHODS USED IN DETOXIFICATION OF MICOTOXINS

Year 2025, Volume: 50 Issue: 4, 629 - 643, 10.08.2025
https://doi.org/10.15237/gida.GD25052

Abstract

Mycotoxins are recognized as a major problem worldwide due to the threat they pose to public health and their negative impact on economies. Therefore, efforts to prevent, partially reduce or completely eliminate mycotoxins in foods are important. When some of the industrial and domestic processes such as heat treatment, fermentation and irradiation applied to prevent mycotoxins in foods are examined, it has been observed that these processes are insufficient to completely remove mycotoxins. Therefore, recent years have focused on the development of complementary strategies and innovative methods to control mycotoxins. Many physical (irradiation, cold plasma, high pressure, pulsed electric fields), chemical (ammonia, chitosan, ozone) and biological (lactic acid bacteria, probiotics) methods are used for mycotoxin detoxification. Compared to physical and chemical methods, detoxification processes by biological methods are considered to be the most promising approach as they cause less loss of nutritional value of food products.

References

  • Abraham, N., Schroeter, K. L., Zhu, Y., Chan, J., Evans, N., Kimber, M. S., Seah, S. Y. (2022). Structure–function characterization of an aldo–keto reductase involved in detoxification of the mycotoxin, deoxynivalenol. Scientific Reports, 12(1), 14737. https://doi.org/10.1038/ s41598-022-19040-8
  • Adeyeye, S.A.O. (2016). Fungal mycotoxins in foods: a review. Cogent Food & Agriculture, 2: 1213127. http://dx.doi.org/10.1080/ 23311932.2016.1213127
  • Afsah-Hejri, L., Hajeb, P., Ehsani, R.J. (2020). Application of ozone for degradation ofmycotoxins in food: A review. Comprehensive Reviews in Food Science and Food Safety 1-32. http://dx.doi.org/10.1111/1541-4337.12594
  • Akbulut, İ. (2023). Sultaniye cinsi kuru üzümde bulunan Okratoksin (OTA) detoksifikasyonunda soğuk plazma teknolojisinin kullanımı ve kalite özelliklerinin incelenmesi. Ege Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisliği Anabilim Dalı Yüksek Lisans Tezi, İzmir Türkiye, 150 s.
  • Alizadeh, A. M., Hashempour-Baltork, F., Khaneghah, A. M., Hosseini, H. (2021). New perspective approaches in controlling fungi and mycotoxins in food using emerging and green technologies. Current Opinion in Food Science, 39, 7-15. http://dx.doi.org/10.1016/j.cofs.2020.12.006
  • Alnaemi, H. S., Dawood, T. N., Algwari, Q. T. (2025). Ultraviolet C and Ozone Application for Detoxification of Aflatoxin B1, Ochratoxin A, and Fumonisin B1 in Poultry Feeds. Egyptian Journal of Veterinary Sciences, 56(4), 797-813. https://doi.org/10.21608/ejvs.2024.277904.1937
  • Aloui, A., Salah-Abbès J.B., Zinedine, A., Riba,A., Durand, N., Meile, J.C.,Montet, D., Catherine Brabet, C., Abbès, S. (2023). Prevention and detoxification of mycotoxins in human food and animal feed using bio-resources from south mediterranean countries: a critical review. Critical Reviews in Toxicology, 53(2), 117-130. https://doi.org/10.1080/10408444.2023.2211178
  • Avsaroglu, M. D., Bozoglu, F., Alpas, H., Largeteau, A., & Demazeau, G. (2015). Use of pulsed-high hydrostatic pressure treatment to decrease patulin in apple juice. High Pressure Research, 35(2), 214-222. https://doi.org/ 10.1080/08957959.2015.1027700
  • Awuchi, C.G., Nyakundi Ondari, E., Ogbonna, C.U., Upadhyay, A.K., Baran, K., Okpala, C.O.R., Korzeniowska, M., Raquel P. F. Guiné, R.P.F. (2021). Mycotoxins affecting animals, foods, humans, and plants: types, occurrence, toxicities, action mechanisms, prevention, and detoxification strategies a revisit. Foods, 10, 1279. https://doi.org/10.3390/foods10061279
  • Babaee, R., Karami-Osboo, R., Mirabolfathy, M. (2021). An overview of effective detoxification methods for aflatoxin-contaminated pistachio. Pistachio and Health Journal, 4(2), 75-93. https://10.22123/PHJ.2021.283744.1096
  • Bahari, HR., Khaneghah, AM., Ismail Eş, I. (2024). Upconversion nanoparticles-modified aptasensors for highly sensitivemycotoxin detection for food quality and safety. Comprehensive Reviews in Food Science and Food Safety, 23(3). https://doi.org/10.1111/1541-4337.13369
  • Balwan, W.K., Neelam Saba, N., Kour, S. (2023). Study of impact of mycotoxins on the human health. Scholars Bulletin, 9(2), 19-23. https://doi.org/10.36348/sb.2023.v09i02.003
  • Benzer Gürel, D. (2023). Atmosferik soğuk plazmanın yüksek ihracat kapasitesine sahip kuru incir ve kuru üzümdeki aflatoksinler ve okratoksin a üzerine etkisi. Manisa Celal Bayar Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisliği Anabilim Dalı Doktora Tezi, Manisa, Türkiye, 127s.
  • Calado, T., Fernández-Cruz, M.L., Verde, S.C., Venâncio, A., Abrunhosa, L. (2018). Gamma irradiation effects on ochratoxin A: Degradation, cytotoxicity and application in food. Food Chemistry, 240, 463–471. http://dx.doi.org/ 10.1016/j.foodchem.2017.07.136
  • Conte, G., Fontanelli, M., Galli, F., Cotrozzi, L., Pagni, L., Pellegrini, E. (2020). Mycotoxins in feed and food and the role of ozone in their detoxification and degradation: An update. Toxins, 12(8), 486. https://doi.org/ 10.3390/toxins12080486
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There are 60 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Food Hygiene and Technology
Journal Section Review
Authors

Hilal Demirpençe 0000-0001-6121-8909

Devrim Beyaz 0000-0001-8935-9850

Submission Date April 11, 2025
Acceptance Date July 21, 2025
Publication Date August 10, 2025
Published in Issue Year 2025 Volume: 50 Issue: 4

Cite

APA Demirpençe, H., & Beyaz, D. (2025). MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER. Gıda, 50(4), 629-643. https://doi.org/10.15237/gida.GD25052
AMA Demirpençe H, Beyaz D. MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER. The Journal of Food. August 2025;50(4):629-643. doi:10.15237/gida.GD25052
Chicago Demirpençe, Hilal, and Devrim Beyaz. “MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL Ve BİYOLOJİK YÖNTEMLER”. Gıda 50, no. 4 (August 2025): 629-43. https://doi.org/10.15237/gida.GD25052.
EndNote Demirpençe H, Beyaz D (August 1, 2025) MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER. Gıda 50 4 629–643.
IEEE H. Demirpençe and D. Beyaz, “MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER”, The Journal of Food, vol. 50, no. 4, pp. 629–643, 2025, doi: 10.15237/gida.GD25052.
ISNAD Demirpençe, Hilal - Beyaz, Devrim. “MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL Ve BİYOLOJİK YÖNTEMLER”. Gıda 50/4 (August2025), 629-643. https://doi.org/10.15237/gida.GD25052.
JAMA Demirpençe H, Beyaz D. MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER. The Journal of Food. 2025;50:629–643.
MLA Demirpençe, Hilal and Devrim Beyaz. “MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL Ve BİYOLOJİK YÖNTEMLER”. Gıda, vol. 50, no. 4, 2025, pp. 629-43, doi:10.15237/gida.GD25052.
Vancouver Demirpençe H, Beyaz D. MİKOTOKSİNLERİN DETOKSİFİKASYONUNDA KULLANILAN FİZİKSEL, KİMYASAL ve BİYOLOJİK YÖNTEMLER. The Journal of Food. 2025;50(4):629-43.