Factors Affecting Bioavailability of Flavonoids (Turkish with English Abstract)

Abstract

The health effects of flavonoids which are highly found in fruits and vegetables were mostly investigated by in vitro studies and the topics of metabolic changes and bioavailability of these compounds in humans were ignored. However, it is of great importance to provide information on the absorption, bioavailability and metabolism of flavonoids in order to evaluate their health effects. Current literature showed that the factors affecting the bioavailability of flavonoids are related with the flavonoid class, its chemical structure, and the glycoside group attached to its structure. In addition, dosage, vehicle of administration, diet, sex differences, individual genetic properties, microbial population of the colon, and other compounds pres¬ent in the food material were also found to affect absorption and bioavailability. In this study, the research studies which investigated the bioavailability of flavonoids and the factors affecting it were investigated.

Keywords

• Bioavailability, absorption, metabolism, flavonoids, health

Flavonoidlerin Biyoyararlılığını Etkileyen Faktörler

Abstract

Meyve ve sebzelerde yüksek düzeyde bulunan flavonoidlerin sağlık üzerindeki olumlu etkileri çoğunlukla in vitro çalışmalarla ortaya konmuş olup bu bileşiklerin insanlardaki metabolik dönüşümleri ve biyoyarar¬lılık konuları göz ardı edilmiştir. Ancak flavonoidlerin sağlık üzerindeki etkileri değerlendirilirken emilimi, biyoyararlılığı ve metabolizması gibi konular hakkında bilgi edinmek oldukça önemlidir. Yapılan çalışmalar flavonoidlerin biyoyararlılığını etkileyen faktörlerin flavonoidin sınıfı, kimyasal yapısı ve yapısında bulunan şeker gruplarıyla ilişkili olduğunu göstermiştir. Ayrıca, alınan dozun ve alım şeklinin, beslenmenin, cinsiyet farklılıklarının, genetik özelliklerin, kolondaki mikrobiyal populasyonun ve tüketilen gıdada mevcut diğer bileşenlerin de emilim ve biyoyararlılığı etkilediği tespit edilmiştir. Bu çalışmada, flavonoidlerin biyoyarar¬lılığı ve bunu etkileyen faktörleri ele alan araştırmalar derlenmiştir.

Keywords

• Biyoyararlılık, emilim, metabolizma, flavonoidler, sağlık

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