Grapefruit Juice and its Interaction with Drugs (Turkish with English Abstract)

Year 2006, Volume: 31 Issue: 2, - , 01.04.2006

Canan Ece Tamer Bige Karaman

Abstract

Grapefruit juice interacts with some drugs and causes adverse effects that can be finalized with death. Especially blood pressure regulating, antihistaminic and cholesterol drugs cause this interaction with naringin, naringenin, furanocumarin, bergapten (5-methoxypsoralen), bergomottin and flavonoids of grapefruit juice. This compounds inhibit decomposition of drugs with the related enzymes in intestines and liver. As a result of this, concentration of the drug in blood is increased and poisioning is occured.

Keywords

Grapefruit juice, Interaction  

Greyfurt Suyu ve İlaçlarla Etkileşimi

Abstract

Greyfurt suyu bazı ilaçlarla etkileşime girerek ölümle sonuçlanabilen yan etkiler oluşturmaktadır. Özellikle tansiyon, kolesterol ve antihistaminik ilaçlarla görülen bu etkileşim, greyfurt suyunda bulunan naringin, naringenin, furanokumarin, bergapten (5-methoxypsoralen), bergomottin ve flavonoidler tarafından gerçekleştirilmektedir. Bu maddeler, ilacın, bağırsak ve karaciğerde bulunan ilgili enzimce parçalanmasını önlemekte ve sonuçta ilacın kandaki konsantrasyonunun artışına bağlı olarak ilaç zehirlenmesi meydana gelmektedir.

Keywords

Greyfurt suyu, Etkileşim 

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