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Glucosinolates and Human Health (Turkish with English Abstract)

Year 2007, Volume: 32 Issue: 6, 293 - 303, 01.12.2007

Abstract

In this review, general chemical structure, nomenclature, content and distribution among plants, degradation products, factors affecting glucosinolate composition, changes during processing and storage, analytical methods, health effects especially for goitrogenic and anticarcinogenic of glucosinolates have been discussed.

References

  • Fenwick GR, Haney RK, Mullin WJ. 1983. Glucosinolates and their breakdown products in food and food plants. Crict. Rev. Food Sci. Nutr. 18, 123-201.
  • Fahey JW, Zalcmann AT, Talalay P. 2001. The chemical diversity and distribution of glucosinolates and isothiocynates among plants. Phytochemistry, 56:5-51.
  • McGregor DI, Mullin WJ, Fenwick GR. 1983. Analytical methodology for determining glucosinolate composition. J. Assoc. Off. Anal. Chem., 66(4), 825-840.
  • Mithen RF, Dekker M, Verkerk R, Rabot S, Johnson IT. 2000. The nutritional signifinance, biosynthesis and bioavailability of glucosinolates in human foods. J. Sci. Food and Agric., 80, 967-984.
  • Cole RA. 1976. Isothiocyanates, nitrilles and thiocyanates as products of autolysis of glucosinolates in cruciferae. Phytochemistry, 15, 759-762.
  • Matthaus B, Fiebig HJ. 1996. Simultaneous determination of isothiocyanates, indoles, and oxazolidinethiones in myrosinase digests of rapeseeds and rapeseed meal by HPLC. J. Agric. Food Chem., 44, 3894-3899.
  • Szimigielska AM, Schoenau JJ, Levers V. 2000. Determination of glucosinolates in canola seeds using anion exchange membrane extraction combined with the high-pressure liquid chromatography. J. Agric. Food Chem., 48, 4487-4491.
  • Kore AM, Spencer F, Walling MA. 1993. Purification of the w-(Methylsulfinyl)alkyl glucosinolate hydrolysis products: 1- Isothiocyanato-3-(methylsulfinyl) propane, 1-Isothiocyanato-4-(methylsulfinyl) butane, 4-(methylsulfinyl) butanenitrile, and 5-(methylsulfinyl) pentannitrile from Broccoli and Lesqurella fendleri. J. Agric. and Food Chem., 41, 89-95.
  • Berteli D, Plessi M, Braghiroli D, Monzani A. 1998. Separation by solid phase extraction and quantification by reserve phase HPLC of sulforaphane in brocccoli. Food Chem., 63(3), 417-421.
  • Troyer JK, Stephenson KK, Fahey JW. 2001. Analysis of glucosinolates from broccoli and other cruciferous vegetables by hydrophilic interaction liquid chromatography. Journal of Chromatography A, 919: 299-304.
  • Delaquis PG, Mazza G. 1995. Antimicrobial properties of isothiocyanates in food preservation. Food Technology, 49(11), 73-84.
  • Peterson CJ, Tsao R, Coats JR. 1998. Glucosinolate aglucones and analogues:insecticidal properties and a QSAR. Pesticide Science, 54, 35-42.
  • Pedras M, Soledade C, Sorensen JL. 1998. Phytoalexin accumulation and antifungal compounds from the crucifer wasabi. Phytochemistry, 49(7), 1959-1965.
  • Ono H, Tesaki S, Tanabe S, Watanabe M. 1998. 6-methylsulfinylhexyl isothicyanate and its homologues as food- originated compounds with antibacterial activity aganist Escherichia coli and Staphhlococcus aureus. Bioscience and Biotechnology and Biochemistry, 62(2), 363-365.
  • Lazzeri L, Tacconi R, Palmieri S. 1993. In vitro activity of some glucosinolates and their reactia products toward a population of the nematode Heterodera schactii. J. Agric. and Food Chem., 41, 825-829.
  • Donkin SG, Eiteman MA, Williams PL. 1995. Toxicity of glucosinolates and their enzymatic decomposition products to carnorhabditis elegans. Journal of Nematology, 27(3), 258-268.
  • Manici LM, Lazzeri L, Palmieri, S. 1997. In vitro fungitoxic activity of some glucosinolates and their enyzme-derived products towards plant pathogenic fungi. J. Agric. and Food Chem., 42, 2768-2773.
  • Freeman GG, Mossadeghi N. 1973. Studies on relationship between water regime and flavour strength in watercress (Rorippa nasturtium-aquacitum (L), cabbage (Brassica oleracea capitata) and onion (Allium cepa). J. Hortic. Sci. 48, 365.
  • MacLeod AJ, MacLeod G. 1968. Volatiles of cooked cabbage. J. Sci. Food and Agric., 19, 273-277.
  • De Vos RH, Blijleven WGH. 1988. The effect of processing conditions on glucosinolates in cruciferous vegetables. Zeitschrift Lebensmittel Untersuchung Forschung, 187, 525-529.
  • Daxenbichler ME, Van Etten CH, Williams PH. 1980. Glucosinolate products in commercial sauerkraut. J. Agric. Food Chem., 28, 809-811.
  • Goodrich RM, Anderson JL, Stoewsand GS. 1989. Glucosinolate changes in blanched broccoli and Brussels sprouts. J. Food Proc. Preserv., 13, 275-280.
  • Wetter LR, Youngs CG. 1976. A thiourea-UV assay for total glucosinolate content in rapeseed meals. J.Am. Oil Chem. Soc. 53, 162-164.
  • VanEtten CH, McGrew CE, Daxenbicher ME. 1974. Glucosinolate determination in cruciferous seed and meals by measurement of enzymatically relaeased glucose. J. Agric. and Food Chem., 22(3), 483-487.
  • McGhee JE, Kirk LD, Mustakas GC. 1965. Methods for determining thioglucosides. in. Crambe abyssinica. Am. Oil Chem. Soc. 42, 889-891.
  • Zhao F, Evans EJ, Bilsborrow PE, Schung E, Syers JK. 1992. Correction for protein content in the determination of the glucosinolate content of rapeseed by the X-RF method. J. Sci. Food and Agric., 58(3), 431-433.
  • Heaney RK, Fenwick GR. 1980. Glucosinolates in Brassicca vegetables. Analysis of 22 varieties of Brussels sprout (Brassica oleracea var. gemmifera). J. Sci. Food and Agric., 31, 785-793.
  • Slominski BA, Campell LD. 1987. Gas chromatographic determination of indole glucosinolates - a re-examination. J. Sci. Food and Agric., 40(2), 131-143.
  • Helboe P, Olsen O, Sorensen J. 1980. Separation of glucosinolates by high performance liquid chromatography. Journal of Chromatography, 197, 199-205.
  • Minchinton I, Sang J, Burke D, Truscott JW. 1982. Separation of desulphoglucosinolates by reversed phase high performance liquid chromatography. Journal of Chromatography, 247, 141-148.
  • Björkqvist B, Hase A. 1988. Speration and determination of intact glucosinolates in rapeseed with HPLC. Journal of Chromatography, 435, 501-507.
  • Kaushik N, Agnihotri A. 1999. HPLC method for separation and quantification of intact glucosinolates. Chromatographia, 49(5/6), 281-284.
  • Nishie K, Daxenbichler ME. 1980. Toxicology of glucosinolate, related compounds (nitriles, R-goitrin, isothiocyanates) and Vitamin K found in Cruciferae. Food and Cosmetics Toxicology, 18(2), 159-172.
  • Yamaguchi T. 1980. Mutagenicity of isothiocyanates, thiocyanates and thioureas on Salmonella typhimurium. Agricultural and Biological Chemistry, 44, 3017-3018.
  • Cemeroğlu B, Yemenicioğlu A, Özkan M. 2001. Meyve ve Sebzelerin Bileşimi, Soğukta Depolanmaları. Gıda Teknolojisi Yayınları No:24, 328 s. Ankara.
  • Greer MA. 1965. The natural occurrence of goitrogenic agents. Recent Progress in Hormone Research, 18, 450-451.
  • Astwood EB. 1943. The chemical nature on compounds which inhibit function of the thyroid gland. The Journal of Pharmacology and Experimental Therapeutics, 78(1), 79-89.
  • World Cancer Research Fund. 1997. Food, Nutrition and the Prevention of Cancer: a Global Perspective, American Institute of Cancer Research, Washington, U.S.A.
  • Keck AS, Finley JW. 2004. Cruciferous Vgetables: Cancer protective mechanism of glucosinolate hydrolysis products and selenium. Integrative Cancer Therapies, 3(1), 5-12.
  • Wattenberg LW. 1977. Inhibition of carcinogenic effects of polycylic hydrocarbons by benzyl isothiocyanate and related compounds. Journal of the National Cancer Institute, 58, 395-398.
  • Fahey JW, Talalay P. 1999. Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enyzmes. Food and Chemical Toxicology, 37, 973-979.
  • Conaway C, Yang-Ming Y, Fung-Lung C. 2002. Isothiocyanates as cancer chemoproventive agents: Their biological activity and metabolism in rodents and humans. Current and Drug Metabolism, 3, 233-255.
  • Jin Y, Mingfu W, Rosen R, Chi-Tang H. 1999. Thermal degradation of sulphoraphane in aqueous solution. J. Agric. and Food Chem. 47: 3121-3223.
  • Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. 1994. Anticarcinogenic activities of sulforaphane and structually related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the U.S.A. 91(8), 3147- 3150.

Glukosinolatlar ve İnsan Sağlığı

Year 2007, Volume: 32 Issue: 6, 293 - 303, 01.12.2007

Abstract

Bu derlemede, glukosinolatların genel kimyasal yapılarına, adlandırılmalarına, bitkilerdeki dağılımına, parçalanma ürünlerine, içerik üzerine etki eden faktörlere, işleme ve depolama sırasında meydana gelen değişimlere, analiz yöntemlerine, sağlık açısından özellikle guatrojenik ve antikarsinojenik etkilerine değinilmiştir.

References

  • Fenwick GR, Haney RK, Mullin WJ. 1983. Glucosinolates and their breakdown products in food and food plants. Crict. Rev. Food Sci. Nutr. 18, 123-201.
  • Fahey JW, Zalcmann AT, Talalay P. 2001. The chemical diversity and distribution of glucosinolates and isothiocynates among plants. Phytochemistry, 56:5-51.
  • McGregor DI, Mullin WJ, Fenwick GR. 1983. Analytical methodology for determining glucosinolate composition. J. Assoc. Off. Anal. Chem., 66(4), 825-840.
  • Mithen RF, Dekker M, Verkerk R, Rabot S, Johnson IT. 2000. The nutritional signifinance, biosynthesis and bioavailability of glucosinolates in human foods. J. Sci. Food and Agric., 80, 967-984.
  • Cole RA. 1976. Isothiocyanates, nitrilles and thiocyanates as products of autolysis of glucosinolates in cruciferae. Phytochemistry, 15, 759-762.
  • Matthaus B, Fiebig HJ. 1996. Simultaneous determination of isothiocyanates, indoles, and oxazolidinethiones in myrosinase digests of rapeseeds and rapeseed meal by HPLC. J. Agric. Food Chem., 44, 3894-3899.
  • Szimigielska AM, Schoenau JJ, Levers V. 2000. Determination of glucosinolates in canola seeds using anion exchange membrane extraction combined with the high-pressure liquid chromatography. J. Agric. Food Chem., 48, 4487-4491.
  • Kore AM, Spencer F, Walling MA. 1993. Purification of the w-(Methylsulfinyl)alkyl glucosinolate hydrolysis products: 1- Isothiocyanato-3-(methylsulfinyl) propane, 1-Isothiocyanato-4-(methylsulfinyl) butane, 4-(methylsulfinyl) butanenitrile, and 5-(methylsulfinyl) pentannitrile from Broccoli and Lesqurella fendleri. J. Agric. and Food Chem., 41, 89-95.
  • Berteli D, Plessi M, Braghiroli D, Monzani A. 1998. Separation by solid phase extraction and quantification by reserve phase HPLC of sulforaphane in brocccoli. Food Chem., 63(3), 417-421.
  • Troyer JK, Stephenson KK, Fahey JW. 2001. Analysis of glucosinolates from broccoli and other cruciferous vegetables by hydrophilic interaction liquid chromatography. Journal of Chromatography A, 919: 299-304.
  • Delaquis PG, Mazza G. 1995. Antimicrobial properties of isothiocyanates in food preservation. Food Technology, 49(11), 73-84.
  • Peterson CJ, Tsao R, Coats JR. 1998. Glucosinolate aglucones and analogues:insecticidal properties and a QSAR. Pesticide Science, 54, 35-42.
  • Pedras M, Soledade C, Sorensen JL. 1998. Phytoalexin accumulation and antifungal compounds from the crucifer wasabi. Phytochemistry, 49(7), 1959-1965.
  • Ono H, Tesaki S, Tanabe S, Watanabe M. 1998. 6-methylsulfinylhexyl isothicyanate and its homologues as food- originated compounds with antibacterial activity aganist Escherichia coli and Staphhlococcus aureus. Bioscience and Biotechnology and Biochemistry, 62(2), 363-365.
  • Lazzeri L, Tacconi R, Palmieri S. 1993. In vitro activity of some glucosinolates and their reactia products toward a population of the nematode Heterodera schactii. J. Agric. and Food Chem., 41, 825-829.
  • Donkin SG, Eiteman MA, Williams PL. 1995. Toxicity of glucosinolates and their enzymatic decomposition products to carnorhabditis elegans. Journal of Nematology, 27(3), 258-268.
  • Manici LM, Lazzeri L, Palmieri, S. 1997. In vitro fungitoxic activity of some glucosinolates and their enyzme-derived products towards plant pathogenic fungi. J. Agric. and Food Chem., 42, 2768-2773.
  • Freeman GG, Mossadeghi N. 1973. Studies on relationship between water regime and flavour strength in watercress (Rorippa nasturtium-aquacitum (L), cabbage (Brassica oleracea capitata) and onion (Allium cepa). J. Hortic. Sci. 48, 365.
  • MacLeod AJ, MacLeod G. 1968. Volatiles of cooked cabbage. J. Sci. Food and Agric., 19, 273-277.
  • De Vos RH, Blijleven WGH. 1988. The effect of processing conditions on glucosinolates in cruciferous vegetables. Zeitschrift Lebensmittel Untersuchung Forschung, 187, 525-529.
  • Daxenbichler ME, Van Etten CH, Williams PH. 1980. Glucosinolate products in commercial sauerkraut. J. Agric. Food Chem., 28, 809-811.
  • Goodrich RM, Anderson JL, Stoewsand GS. 1989. Glucosinolate changes in blanched broccoli and Brussels sprouts. J. Food Proc. Preserv., 13, 275-280.
  • Wetter LR, Youngs CG. 1976. A thiourea-UV assay for total glucosinolate content in rapeseed meals. J.Am. Oil Chem. Soc. 53, 162-164.
  • VanEtten CH, McGrew CE, Daxenbicher ME. 1974. Glucosinolate determination in cruciferous seed and meals by measurement of enzymatically relaeased glucose. J. Agric. and Food Chem., 22(3), 483-487.
  • McGhee JE, Kirk LD, Mustakas GC. 1965. Methods for determining thioglucosides. in. Crambe abyssinica. Am. Oil Chem. Soc. 42, 889-891.
  • Zhao F, Evans EJ, Bilsborrow PE, Schung E, Syers JK. 1992. Correction for protein content in the determination of the glucosinolate content of rapeseed by the X-RF method. J. Sci. Food and Agric., 58(3), 431-433.
  • Heaney RK, Fenwick GR. 1980. Glucosinolates in Brassicca vegetables. Analysis of 22 varieties of Brussels sprout (Brassica oleracea var. gemmifera). J. Sci. Food and Agric., 31, 785-793.
  • Slominski BA, Campell LD. 1987. Gas chromatographic determination of indole glucosinolates - a re-examination. J. Sci. Food and Agric., 40(2), 131-143.
  • Helboe P, Olsen O, Sorensen J. 1980. Separation of glucosinolates by high performance liquid chromatography. Journal of Chromatography, 197, 199-205.
  • Minchinton I, Sang J, Burke D, Truscott JW. 1982. Separation of desulphoglucosinolates by reversed phase high performance liquid chromatography. Journal of Chromatography, 247, 141-148.
  • Björkqvist B, Hase A. 1988. Speration and determination of intact glucosinolates in rapeseed with HPLC. Journal of Chromatography, 435, 501-507.
  • Kaushik N, Agnihotri A. 1999. HPLC method for separation and quantification of intact glucosinolates. Chromatographia, 49(5/6), 281-284.
  • Nishie K, Daxenbichler ME. 1980. Toxicology of glucosinolate, related compounds (nitriles, R-goitrin, isothiocyanates) and Vitamin K found in Cruciferae. Food and Cosmetics Toxicology, 18(2), 159-172.
  • Yamaguchi T. 1980. Mutagenicity of isothiocyanates, thiocyanates and thioureas on Salmonella typhimurium. Agricultural and Biological Chemistry, 44, 3017-3018.
  • Cemeroğlu B, Yemenicioğlu A, Özkan M. 2001. Meyve ve Sebzelerin Bileşimi, Soğukta Depolanmaları. Gıda Teknolojisi Yayınları No:24, 328 s. Ankara.
  • Greer MA. 1965. The natural occurrence of goitrogenic agents. Recent Progress in Hormone Research, 18, 450-451.
  • Astwood EB. 1943. The chemical nature on compounds which inhibit function of the thyroid gland. The Journal of Pharmacology and Experimental Therapeutics, 78(1), 79-89.
  • World Cancer Research Fund. 1997. Food, Nutrition and the Prevention of Cancer: a Global Perspective, American Institute of Cancer Research, Washington, U.S.A.
  • Keck AS, Finley JW. 2004. Cruciferous Vgetables: Cancer protective mechanism of glucosinolate hydrolysis products and selenium. Integrative Cancer Therapies, 3(1), 5-12.
  • Wattenberg LW. 1977. Inhibition of carcinogenic effects of polycylic hydrocarbons by benzyl isothiocyanate and related compounds. Journal of the National Cancer Institute, 58, 395-398.
  • Fahey JW, Talalay P. 1999. Antioxidant Functions of Sulforaphane: a Potent Inducer of Phase II Detoxication Enyzmes. Food and Chemical Toxicology, 37, 973-979.
  • Conaway C, Yang-Ming Y, Fung-Lung C. 2002. Isothiocyanates as cancer chemoproventive agents: Their biological activity and metabolism in rodents and humans. Current and Drug Metabolism, 3, 233-255.
  • Jin Y, Mingfu W, Rosen R, Chi-Tang H. 1999. Thermal degradation of sulphoraphane in aqueous solution. J. Agric. and Food Chem. 47: 3121-3223.
  • Zhang Y, Kensler TW, Cho CG, Posner GH, Talalay P. 1994. Anticarcinogenic activities of sulforaphane and structually related synthetic norbornyl isothiocyanates. Proceedings of the National Academy of Sciences of the U.S.A. 91(8), 3147- 3150.
There are 44 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Oktay Yemiş This is me

Nevzat Artık This is me

Publication Date December 1, 2007
Published in Issue Year 2007 Volume: 32 Issue: 6

Cite

APA Yemiş, O. ., & Artık, N. . (2007). Glukosinolatlar ve İnsan Sağlığı. Gıda, 32(6), 293-303.
AMA Yemiş O, Artık N. Glukosinolatlar ve İnsan Sağlığı. The Journal of Food. December 2007;32(6):293-303.
Chicago Yemiş, Oktay, and Nevzat Artık. “Glukosinolatlar Ve İnsan Sağlığı”. Gıda 32, no. 6 (December 2007): 293-303.
EndNote Yemiş O, Artık N (December 1, 2007) Glukosinolatlar ve İnsan Sağlığı. Gıda 32 6 293–303.
IEEE O. . Yemiş and N. . Artık, “Glukosinolatlar ve İnsan Sağlığı”, The Journal of Food, vol. 32, no. 6, pp. 293–303, 2007.
ISNAD Yemiş, Oktay - Artık, Nevzat. “Glukosinolatlar Ve İnsan Sağlığı”. Gıda 32/6 (December 2007), 293-303.
JAMA Yemiş O, Artık N. Glukosinolatlar ve İnsan Sağlığı. The Journal of Food. 2007;32:293–303.
MLA Yemiş, Oktay and Nevzat Artık. “Glukosinolatlar Ve İnsan Sağlığı”. Gıda, vol. 32, no. 6, 2007, pp. 293-0.
Vancouver Yemiş O, Artık N. Glukosinolatlar ve İnsan Sağlığı. The Journal of Food. 2007;32(6):293-30.

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