A New Approach to Counteracting Obesity: Diacylglycerol Oil (Turkish with English Abstract)

Year 2013, Volume: 38 Issue: 5, 315 - 322, 01.10.2013

Şükran Kuleaşan

Abstract

Recent years studies on the use of diacylglycerol oil in as edible oil has become focus of attention. Diacylglycerol oil has liquid character and contains about 80-81% of diglycerides. Diacylglycerol oil is very similar to triacylglycerol oil in terms of physicochemical properties. Besides, it has unique crystallization and plasticity characteristics features for the development of new products. Human studies and animal feeding experiments have shown that diacylglycerol oil is metabolized in a different pathway than that of triacylglycerol oil. Therefore, diacylglycerol oil has been reported to be effective on decreasing body fat mass, suppression of hypertriglyceridemia together with hypertension, controlling fluctuations of blood serum lipids and insulin in high risk-group individuals for cardiovascular problems. This article provides information about the relationship between diacylglycerol oil and health.

Keywords

Diacylglycerol oil, obesity, health.

Obeziteile Mücadelede Yeni Bir Yaklaşım: Digliserit Yağ

Abstract

Son yıllarda digliserit yağın yemeklik yağ olarak kullanımına yönelik çalışmalar ilgi odağı haline gelmiştir. Yemeklik digliserit yağ sıvı karakterde olup, yaklaşık %80-81 oranında digliserit içermektedir. Fizikokimyasal özellikleri bakımından trigliserit yağlara oldukça benzerlik gösteren bu yağın ayrıca yeni ürün geliştirmeye yönelik kendine has kristalizasyon ve plastisite özellikleri de vardır. İnsanlarda ve hayvan besleme deneyleri ile yapılan çalışmalarda, digliserit yağın trigliserit yağdan farklı bir şekilde metabolize olduğu; bu nedenle de digliserit yağın, vücuttaki yağ kitlesinin azalmasında, hipertrigliseridemi ve beraberinde seyreden hipertansiyonun baskılanmasında, kalp damar sağlığı bakımından yüksek risk grubundaki bireylerin kan serumundaki lipit ve insülin değerlerindeki dalgalanmaların kontrol altına alınmasında etkili olduğu bildirilmiştir. Bu makalede digliserit yağ ve sağlık ilişkisi hakkında bilgi verilmiştir.

Keywords

Digliserit yağ, obezite, sağlık.

References

• Anonym. 2013. World Health Organization. Obesity and overweight. Fact sheet N°311, March 2013. http://www.who.int/mediacentre/factsheets/ fs311/en/ (Eriflim tarihi: 20.04.2013)
• Hamam F, Shahidi F. 2008. Incorporation of selected long-chain fatty acids into trilinolein and trilinolenin. Food Chem, 106, 33-39.
• Akoh CC, Kim BH. 2008. Structured Lipids. In: Food Lipids: Chemistry Nutrition and Biotechnology. (Akoh, C.C., Min, D.B.,-eds.), Third Edition, CRC Press, pp. 841-872.
• Akoh CC, Xu X. 2002. Enzymatic Production of Betapol and Other Specialty Fats. In: Lipid Biotechnology.(Kuo, T.M., Gardner, H.W., -eds.), Marcel Dekker Inc., New York, pp. 461-478.
• Marangoni AG. 2002. Lipases: Structure, Function, and Properties. In: Lipid Biotechnology. (Kuo, T.M., Gardner, H.W., -eds.), Marcel Dekker Inc., New York, pp. 357 - 386.
• Wong WC, Basri M, Razak CAN, Salleh AB. 2000. Synthesis of medium-chain glycerides using lipase from Candida rugosa. J Am Oil Chem Soc, 77, 85-88.
• Yang TH, Jang Y, Han JJ, Rhee JS. 2001. Enzymatic synthesis of low-calori structured lipids in a solvent-free system. J Am Oil Chem Soc, 78, 291-296. 8. Willis WM, Marangoni AG. 2002. Enzymatic Interesterification. In: Food Lipids: Chemistry Nutrition and Biotechnology.(Akoh, C.C., Min, D.B.,-eds.), Marcel Dekker Inc., New York., pp. 837-875.
• Xue C, Liu Y,Wang J, Zhang R, Zhang Y, Zhang J, Zheng Z, Yu X, Jing H, Nosaka N, Arai C, Kasai M, Aoyama T, Wu J. 2009. Consumption of medium- and long-chain triacylglycerols decreases body fat and blood triglyceride in chinese hypertriglyceridemic subjects. Eur J Clin Nutr, 63(7), 879-886.
• Uribe AR, Hernandez E. 2004. Solvent-free enzymatic synthesis of structured lipids containing CLA from coconut oil and tricaprylin. J Am Oil Chem Soc,81, 685-689.
• Zhang Y, Liu Y, Wang J, Zhang R, Jing H, Yu X, Zhang Y, Xu Q, Zhang J, Zheng Z, Nosaka N, Arai C, Kasai M, Aoyama T, Wu J, Xue C. 2010. Medium- and long-chain triacylglycerols reduce body fat and blood triacylglycerols in hypertriacylglycerolemic, overweight but not obese, Chinese individuals. Lipids, 45(6), 501-510.
• Watkins BA, Li Y, Hennig B, Toborek M. 2005. Dietary Lipids and Health. In: Bailey’s Industrial Oil And Fat Products,Sixth Edition, Volume 1, Edible Oil and Fat Products: Chemistry, Properties, and Health Effects. (Edited by Fereidoon Shahidi), A John Wiley & Sons Inc., New Jersey, pp. 1:213-267.
• Sandrou DK, Arvanitoyannis IS. 2000. Low-Fat/ Calorie Foods: Current state and perspectives. Crit Rev Food Sci Nutr, 40(5), 427-447.
• Auerbach MH, Klemann LP, Heydinger JA. 2001. Reduced-Energy Lipids. In: Structured and Modified Lipids.(Edited by Frank D. Gunstone), Marcel Dekker, Inc., New York, pp. 485-510.
• Senanayake SPJN, Shahidi F. 2005. Dietary Fat Substitutes. In: Bailey’s Industrial Oil And Fat Products,Sixth Edition, Volume 3, Edible Oil and Fat Products: Specialty Oils and Oil Products. (Edited by Fereidoon Shahidi), A John Wiley & Sons Inc., New Jersey, pp. 3, 503-534.
• Stein J. 1999. Chemically defined structured lipids: current status and future directions in gastrointestinal diseases. Int J Colorectal Dis, 14, 79-85.
• Mu H, Porsgaard T. 2005. The metabolizm of structured triacylglycerols. Prog Lipid Res, 44, 430-448.
• Vamecq J, Vallée L, Lesage F, Gressens P, Stables JP. 2005. Antiepileptic popular ketogenic diet: Emerging twists in an ancient story. Prog Neurobiol,75, 1-28.
• Marten B, Pfeuffer M, Schrezenmeir J. 2006. Medium-chain triglycerides. Int Dairy J, 16, 1374-1382. 24. Mu H, H y CE. 2000. Effects of different medium-chain fatty acids on intestinal absorption of structured triacylglycerols. Lipids, 35, 83-89.
• Tsuji H, Takeuchi H, Nakamura M, Okazaki M, Kondo K. 2001. Dietary medium-chain triacylglycerols suppress accumulation of body fat in a double-blind, controlled trial in healthy men and women. J Nutr, 131(11), 2853-2859.
• Reena MB, Lokesh BR. 2007. Hypolipidemic effect of oils with balanced amounts of fatty acids obtained by blending and interesterification of coconut oil with rice bran oil or sesame oil. J Agric Food Chem, 55, 10461-10469.
• Taguchi H, Watanabe H, Onizawa K, Nagao T, Gotoh N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. 2000. Double-blind controlled study on the effects of dietary diacylglycerol on postprandial serum and chylomicron triacylglycerol responses in healthy humans. J Am Coll Nutr, 19(6), 789-796.
• Yasukawa T, Katsuragi Y. 2008. Diacylglycerols. In: Diacylglycerol Oil. (Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., -eds.), Second Edition, AOCS Press, Champaign IL., pp. 1-16.
• Maki KC, Matsuo N, Dicklin MR. 2008. Clinical studies evaluating the benefits of diacylglycerol for managing excess adiposity. In: Diacylglycerol Oil.(Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., -eds.), Second Edition, AOCS Press, Champaign IL., pp. 109-123.
• Kristensen JB, J rgensen H, Mu H. 2006. Diacylglycerol oil does not affect portal vein transport of nonesterified fatty acids but decreases the postprandial plasma lipid response in catheterized pigs. J Nutr, 136(7), 1800-1805.
• Kim HJ, Lee KT, Lee MK, Jeon SM, Choi MS. 2006. Diacylglycerol-enriched structured lipids containing CLA and capric acid alter body fat mass and lipid metabolism in rats. Ann Nutr Metab, 50(3), 219-228.
• Yanai H, Tomono Y, Ito K, Furutani N, Yoshida H, Tada N. 2007. Diacylglycerol oil for the metabolic syndrome. Nutrition Journal, 6, 43.
• Yang T, Zhang H, Mu H, Sinclair AJ, Xu X. 2004. Diacylglycerols from butterfat: Production by glycerolysis and short-path distillation and analysis of physical properties. J Am Oil Chem Soc, 81, 979–987.
• Craven RJ, Lencki RW. 2010. Preparation of diacid 1,3-diacylglycerols. J Am Oil Chem Soc, 87, 1281-1291.
• Kahveci D, Guo Z, Özçelik B, Xu X, 2009. Lipase-catalyzed glycerolysis in ionic liquids directed towards diglyceride synthesis. Process Biochem, 44, 1358-1365.
• Wang Y, Zhao M, Ou S, Song K. 2009. Partial hydrolysis of soybean oil by phospholipase A1 to produce diacylglycerol-enriched oil. J Food Lipids, 16, 113-132.
• Wang L, Wang Y, Hu C, Cao Q, Yang X, Zhao M. 2011. Preparation of diacylglycerol-enriched oil from free fatty acids using lecitase ultra- catalyzed esterification. J Am Oil Chem Soc, 88, 1557-1565.
• Duan ZQ, Du W, Liu DH. 2012. Rational synthesis of 1,3-diolein by enzymatic esterification. J Biotechnol, 159, 44-49.
• Liu N, Wang Y, Zhao Q, Cui C, Fu M, Zhao M. 2012. Immobilisation of lecitase ultra for production of diacylglycerols by glycerolysis of soybean oil. Food Chem, 134, 301-307.
• Feltes MMC, Villeneuve P, Bare´a B, Barouh N, Oliveira JV, Oliveira D, Ninow JL. 2012. Enzymatic production of monoacylglycerols (MAG) and diacylglycerols (DAG) from fish oil in a solvent-free system. J Am Oil Chem Soc, 89, 1057-1065.
• Nishide T, Shimizu M, Tiffany TR, Ogawa H. 2008. Cooking Oil: Cooking Properties and Sensory Evaluation. In: Diacylglycerol Oil. (Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., -eds.), Second Edition, AOCS Press, Champaign IL., pp. 219-229.
• Craven RJ, Lencki RW. 2011. Binary phase behavior of diacid 1,3-diacylglycerols. J Am Oil Chem Soc, 88, 1125-1134.
• Craven RJ, Lencki RW. 2011. Crystallization and polymorphism of 1,3-acyl-palmitoyl- rac-glycerols. J Am Oil Chem Soc, 88, 1113-1123. 48. Hatzakis E, Agiomyrgianaki A, Kostidis S, Dais P. 2011. High-resolution NMR spectroscopy: An alternative fast tool for qualitative and quantitative analysis of diacylglycerol (DAG) oil. J Am Oil Chem Soc, 88, 1695-1708.
• Saberi AH, Lai OM, Toro-Vázquez JF. 2011. Crystallization kinetics of palm oil in blends with palm-based diacylglycerol. Food Res Int, 44(1), 425-435.
• Saberi AH, Chin-Ping T, Oi-Ming L. 2011. Phase behavior of palm oil in blends with palm-based diacylglycerol. J Am Oil Chem Soc, 88, 1857-1865.
• Saitou K, Mitsui Y, Shimizu M, Kudo N, Katsuragi Y, Sato K. 2012. Crystallization behavior of diacylglycerol rich oils produced from rapeseed oil. J Am Oil Chem Soc, 89, 1231-1239.
• Miklos R, Zhang H, Lametsch R, Xu X. 2013. Physicochemical properties of lard-based diacylglycerols in blends with lard. Food Chem, 138, 608-614.
• Watanabe H, Tokimitsu I. 2008. Digestion and Absorption of Diacylglycerol. In: Diacylglycerol Oil. (Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., - eds.), Second Edition, AOCS Press, Champaign IL., pp. 31-47.
• Flickinger BD, Matsuo N. 2003. Nutritional characteristics of DAG oil. Lipids, 38, 129-132.
• Maki KC, Davidson MH, Tsushima R, Matsuo N, Tokimitsu I, Umporowicz DM, Dicklin MR, Foster GS, Ingram KA, Anderson BD, Frost SD, Bell M. 2002. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil1-3. Am J Clin Nutr, 76(6), 1230-1236.
• Nagao T, Watanabe H, Goto N, Onizawa K, Taguchi H, Matsuo N, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. 2000. Dietary diacylglycerol suppresses accumulation of body fat compared to triacylglycerol in men in a double-blind controlled trial. J Nutr, 130(4), 792-797.
• Yuan Q, Ramprasath VR, Harding SV, Rideout TC, Chan YM, Jones PJH. 2010. Diacylglycerol oil reduces body fat but does not alter energy or lipid metabolism in overweight, hypertriglyceridemic women. J Nutr, 140, 1122-1126.
• Hibi M, Sugiura Y, Yokoyama R, Takase H, Shiiba D, Meguro S, Katashima M, Shimizu A, Tokimitsu I. 2011. The short-term effect of diacylglycerol oil consumption on total and dietary fat utilization in overweight women. Obesity, 19(3), 536-540.
• Watanabe H, Onizawa K, Naito S, Taguchi H, Goto N, Nagao T, Matsuo N, Tokimitsu I, Yasukawa T, Tsushima R, Shimasaki H, Itakura H. 2001. Fat-soluble vitamin status is not affected by diacylglycerol consumption. Ann Nutr Metab, 45, 259-264.
• Morita O, Soni MG. 2009. Safety assessment of diacylglycerol oil as an edible oil: A review of the published literature. Food Chem Toxicol, 47, 9-21.
• Lee YY, Tang TK, Lai OM. 2012. Health benefits, enzymatic production, and application of medium- and long-chain triacylglycerol (MLCT) in food industries: A review. J Food Sci, 77(8), 137-144.
• Lo SK, Tan CP, Long K, Yusoff MSA, Lai OM. 2008. Diacylglycerol oil-Properties, processes and products: A review. Food Bioprocess Technol, 1, 223-233.
• Borzelleca JF, Glinsmann W, Kennepohl E. 2008. Safety aspects of diacylglycerol oil. In: Diacylglycerol Oil. (Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., -eds.), Second Edition, AOCS Press, Champaign IL., pp. 182-203.
• Watanabe T, Yamaguchi H, Yamada N, Lee I. 2008. Manufacturing process of diacylglycerol oil. In: Diacylglycerol Oil. (Katsuragi, Y., Yasukawa, T., Matsuo, N., Flickinger, B., Tokimitsu, I. and Matlock, M., -eds.), Second Edition, AOCS Press, Champaign IL., pp. 275-284.
• Kuleaflan fi. 2011. Orta zincir uzunlu¤undaki ya¤ asitlerini yüksek miktarda içeren yapılandırılmıfl ya¤ların enzimatik interesterifikasyon yöntemi ile üretimi ve sa¤lık üzerindeki etkilerinin belirlenmesi. Süleyman Demirel Üniversitesi Fen Bilimleri Enstitüsü Gıda Mühendisli¤i Anabilim Dalı Doktora Tezi, Isparta, Türkiye, 90s.
• Hernandez-Martin E, Hill Jr CG, Otero C. 2009. Selective synthesis of diacylglycerols of conjugated linoleic acid. J Am Oil Chem Soc, 86, 427-435.
• Zhong N, Gui Z, Xu L, Huang J, Hu K, Gao Y, Zhang X, Xu Z, Su J, Li B. 2013. Solvent-free enzymatic synthesis of 1, 3-Diacylglycerols by direct esterification of glycerol with saturated fatty acids. Lipids in Health and Disease, 12:65.
• Kawashima H, Takase H, Yasunaga K, Wakaki Y, Katsuragi, Y, Mori K, Yamaguchi T, Hase T, Matsuo N, Yasukawa T, Tokimitsu I, Koyama W. 2008. One-year ad libitum consumption of diacylglycerol oil as part of a regular diet results in modest weight loss in comparison with consumption of a triacylglycerol control oil in overweight Japanese subjects. J Am Diet Assoc, 108, 57-66.