Review
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APTAMER BASED IDENTIFICATION METHOD AND ITS APPLICATIONS IN FOOD SAFETY

Year 2024, Volume: 49 Issue: 3, 536 - 553

Melike Canpolat Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Abstract

Aptamers are single-stranded, short, synthetic nucleic acid sequences. Aptamers, which show high affinity and specific binding to various target molecules, are used for the sensitive detection of various risk factors such as pathogenic microorganisms, biotoxins, allergens, pesticides and heavy metals that may be present in foods. The selection of aptamers specifically binding to molecules that pose a risk in terms of food safety is carried out through a process called SELEX. The selected aptamer interacts specifically with the target molecule and this interaction is measured using electrochemical, optical, or other biosensor techniques. There is a growing interest in aptamer-based methods with high specificity and sensitivity, which provide faster results compared to conventional methods used in food analysis. This review summarized the general properties of aptamers and their production by the SELEX principle and given examples of their applications in food safety.

Keywords

Aptamer SELEX biosensor biomarker molecule contamination food safety

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APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI

Year 2024, Volume: 49 Issue: 3, 536 - 553

Melike Canpolat Zülal Kesmen

https://doi.org/10.15237/gida.GD23145

Abstract

Aptamerler, tek sarmallı, kısa, sentetik nükleik asit dizileridir. Çeşitli hedef moleküllere karşı yüksek afinite gösteren ve spesifik olarak bağlanan aptamerler, gıdalarda bulunabilecek patojen mikroorganizmalar, biyotoksinler, alerjenler, pestisitler ve ağır metaller gibi çeşitli risk faktörlerinin hassas bir şekilde tespiti için kullanılmaktadır. Gıda güvenliği açısından risk oluşturan moleküllere spesifik olarak bağlanan aptamerlerin seçilmesi SELEX adı verilen bir süreçle gerçekleştirilir. Seçilen aptamer, hedef molekül ile özgün olarak etkileşime girer ve bu etkileşim elektrokimyasal, optik veya diğer biyosensör teknikler kullanılarak ölçülür. Gıda analizlerinde kullanılan geleneksel yöntemlere kıyasla daha hızlı sonuçlar veren, yüksek özgüllüğe ve duyarlılığa sahip aptamer tabanlı yöntemlere duyulan ilgi giderek artmaktadır. Bu derlemede aptamerlerin genel özellikleri ve SELEX prensibiyle üretimleri özetlenmiş ve gıda güvenliği alanındaki uygulamalarına örnekler verilmiştir.

Keywords

Aptamer SELEX biyobelirteç molekülü biyosensör kontaminasyon gıda güvenliği

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There are 106 citations in total.

Details

Primary Language Turkish
Subjects Food Biotechnology
Journal Section Articles
Authors

Melike Canpolat 0000-0003-0345-465X

Zülal Kesmen 0000-0002-4505-6871

Publication Date
Submission Date December 26, 2023
Acceptance Date April 30, 2024
Published in Issue Year 2024 Volume: 49 Issue: 3

Cite

APA Canpolat, M., & Kesmen, Z. (n.d.). APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda, 49(3), 536-553. https://doi.org/10.15237/gida.GD23145
AMA Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. The Journal of Food. 49(3):536-553. doi:10.15237/gida.GD23145
Chicago Canpolat, Melike, and Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49, no. 3 n.d.: 536-53. https://doi.org/10.15237/gida.GD23145.
EndNote Canpolat M, Kesmen Z APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. Gıda 49 3 536–553.
IEEE M. Canpolat and Z. Kesmen, “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”, The Journal of Food, vol. 49, no. 3, pp. 536–553, doi: 10.15237/gida.GD23145.
ISNAD Canpolat, Melike - Kesmen, Zülal. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda 49/3 (n.d.), 536-553. https://doi.org/10.15237/gida.GD23145.
JAMA Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. The Journal of Food.;49:536–553.
MLA Canpolat, Melike and Zülal Kesmen. “APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI”. Gıda, vol. 49, no. 3, pp. 536-53, doi:10.15237/gida.GD23145.
Vancouver Canpolat M, Kesmen Z. APTAMER TABANLI TANIMLAMA YÖNTEMİ VE GIDA GÜVENLİĞİNDEKİ UYGULAMALARI. The Journal of Food. 49(3):536-53.
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