The Effect of Serum Igf-1,Igfbp-3 And Erythrocyte Transfusıons on Development of Mıld Retınopathy of Prematurıty

Year 2019, Volume: 9 Issue: 1, 9 - 14, 27.03.2019

Davut Bozkaya Ebru Ergenekon Aysegul Yucel Sengul Ozdek İbrahim Hirfanoglu Ozden Turan Canan Turkyilmaz Esra Onal Esin Koc Yıldız Atalay

https://doi.org/10.16899/gopctd.535602

Abstract

Introduction:
Most important factors in retinopathy of prematurity (ROP) are prematurity and
oxygen toxicity although blood transfusions, insulin like growth factor-1 (
IGF-1), insulin like growth factor binding protein 3 (IGFBP-3) and vascular
endothelial growth factor (VEGF) also have important roles.

The
objectives of this study were, to measure IGF-1 and IGFBP-3 levels in preterm
newborns before and after blood transfusion and assess if the effect of
transfusion in development of ROP is via these mediators, and to investigate
whether IGF-1 and IGFBP-3 levels measured at 32 and 33 gestational age (GA)
were different in preterm newborns with and without ROP.

Material
and Methods: Preterm newborns with gestational age ≤34 weeks were included and
blood samples were obtained before and after red blood cell (RBC) transfusion.

Results:
Thirty newborns were included, 17 of whom had ROP ( stage 1: n=11, stage 2:
n=5, stage 3: n=1). IGF-1 and IGFBP-3 levels did not change after RBC
tranfusion. Excluding the patient with stage 3 ROP all ROP patients were
referred as mild ROP. No difference was observed between IGF-1 and IGFBP-3
levels of the patients with and without mild ROP. Patients with mild ROP had
significantly more number of transfusions.

Conclusions:
Erythrocyte transfusion increased the frequency of ROP, whereas IGFBP-3 and
IGF-1 were not associated of ROP.

Keywords

Retinopathy of prematurity, IGF-1, IGFBP-3

References

• REFERENCES:1- Good WV, Hardy RJ, Dobson V, et al. Early treatment for retinopathy of prematurity cooperative group. The incidence and course of retinopathy of prematurity:findings fromthe earlytreatment of retinopathy of prematurity study. Pediatrics 2005;116(1):15-23.
• 2- Mathew MR, Fern AI, Hill R. Retinopathy of prematurity: Are we screening too many babies? Eye 2002;16(5):538-542.
• 3- Bas AY, Demirel N, Koc E, Ulubas Isik D, Hirfanoglu İM, Tunc T; TR-ROP Study Group. Incidence, risk factors and severity of retinopathy of prematurity in Turkey (TR-ROP study): a prospective, multicentre study in 69 neonatal intensive care units. prospective, multicentre study in 69 neonatal intensive care units. Br J Ophthalmol. 2018 Mar 8.
• 4- Smolkin T, Steinberg M, Sujov P,et al. Late postnatal systemic steroids predispose to retinopathy of prematurity in very low birth weight infants:a comparative study. Acta Paediatrica 2008;97(3):322-326.
• 5- Bizzarro MJ, Hussein N, Jonsson B, et al. Genetic susceptibility in retinopathy of prematurity. Pediatrics 2006;118(5):1858-1863.
• 6- Coleman R, Beharry KD, Brock RS, et al. Effects of brief , clustered versus dispersed hypoxic episodes on systemic and ocular growth factors in a rat model of oxygen induced retinopathy. Pediatr Res 2008;64(1):50-55.
• 7- Zhang S, Zhou R, Li B, et al. Caffeine preferentially protects against oxygen-induced retinopathy. FASEB J. 2017 Aug;31(8):3334-3348.
• 8- Hellstrom A, Perruzzi C, Ju M, Engstrom E . Low IGF-1 suppresses VEGF-survival signaling in retinal endothelial cells: Direct correlation with clinical retinopathy of prematurity. PNAS 2001; 98(10):5804-5808.
• 9- Chen J, Smith LE. Retinopathy of prematurity. Angiogenesis 2007;10(2):133-140.
• 10- Smith LE. Pathogenesis of retinopathy of prematurity Growth Hormone and IGF. Growth Horm IGF Res 2004;14:S140-S144.11- Smith LE. Pathogenesis of retinopathy of prematurity. Semin Perinatol 2003;8(6):469-473.
• 12- Yeung MY. Somatotropic axis derangement as an underlying factor in the genesis of retinopathy of prematurity. Acta Paediatrica 2006;95(11):1334-1340.
• 13- Dani C, Reali MF, Bertini G,et al. The role of blood transfusions and iron intake on retinopathy of prematurity. Earl Hum Dev 2001;62(1):57-63.
• 14- Hesse L, Eberl W, Schlaud M, et al. Blood transfusion iron load and retinopathy of prematurity. Eur J Pediatr 1997;156(6):465-470.
• 15- Azami M, Jaafari Z, Rahmati S, Farahani AD, Badfar G. Prevalence and risk factors of retinopathy of prematurity in Iran: a systematic review and meta-analysis. BMC Ophthalmol. 2018 Apr 2;18(1):83.
• 16- Hübler A, Knote K, Kauf E, et al. Does insulin-like growth factor 1 contribute in red blood cell transfusions to the pathogenesis of retinopathy of prematurity during retinal neovascularization? Biol Neonate 2006;89(2):92-98.
• 17- Lofqvist C, Chen J, Connor KM, et al. IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular growth. PNAS 2007;104(25): 10589-10594.
• 18- Rajah R, Valenitis B, Cohen P. Insulin-like growth factor binding protein-3 induces apoptosis and mediates the effects of transforming growth factor beta 1 on programmed cell death through a p53 and IGF independent mechanism. J Biol Chem 1997; 272(18):12181-12188.
• 19- American Academy of Pediatrics,American Academy of Opthalmology, American Association for Pediatric Opthalmology and Strabismus. Screening examination for premature infants for retinopathy of prematurity. Policy Statement. Pediatrics 2013 Jan;131(1):189-95.
• 20- International committee for the classification of retinopathy of prematurity. The international classification of retinopathy of prematurity revisited. Arch Opthalmol 2005;123(7):991-999.
• 21- Hellstrom A, Engstrom E, Hard AL, et al. Postnatal insulin-like growth factor deficiency is associated with retinopathy of prematurity and other complications of premature birth. Pediatrics 2003;112(5):1016-1020.
• 22- Lofqvist C, Enstrom E, Sigudsson J, et al. Postnatal head growth deficit among premature infants parallels retinopathy of prematurity and insulin-like growth factor deficit. Pediatrics 2006;117(6):1930-1938.
• 23- Modanlou HD, Gharraee Z, Hasan J et al. Ontogeny of VEGF, IGF-1, and GH in neonatal rat serum vitreous fluid, and retina from birth to weaning. Invest Opthtalmol Vis Sci 2006;47(2):738-744
• 24- Hellstrom A, Carlsson B, Niklasson A, et al. IGF-1 is critical for normal vascularization of the human retina. J Clin Endocrinol Metab 2002 ; 87(7):3413-3416.
• 25- Hansen-Pupp IH, Hellstrom-Westas L, Cilio CM, et al . Inflammation at birth and the insulin-like growth factor system in very preterm infants. Acta Paediatrica 2007;96(6): 830-836.