BARİATRİK CERRAHİ UYGULAMALARININ MİKROBİYOTA ÜZERİNE ETKİLERİNİN DEĞERLENDİRİLMESİ

Yıl 2018, Cilt: 3 Sayı: 1, 38 - 44, 30.03.2018

Zeynep Uzdil , Mendane Saka

Öz

Obezitenin
tedavisine ve bazı kronik hastalıkların önlenmesine yardımcı olan bariatrik
cerrahi uygulaması vücutta çeşitli fizyolojik etkilere neden olmaktadır.
Bunlardan birisi mikrobiyota olarak adlandırılan bağırsak florasının içeriğinin
değişmesidir. Cerrahi sonrası mikrobiyotanın değerlendirildiği insan ve rat
çalışmalarında mikrobiyotanın önemli filumu olan Firmicutes ve
Bacteroidetes bakterilerinde bu değişiminin daha çok görüldüğü
bilinmektedir. Bağırsakta daha çok kısa zincirli yağ asidi üretimine ve
emilimine neden olan Firmicutes filumunda cerrahi sonrası azalma
olmaktadır. Cerrahi sonrasında safraya dirençli olan Proteobacteria filumundaki bakterilerde
artış olduğu bilinmektedir. Cerrahiye bağlı metabolik değişikliklerin
mikrobiyal içeriği etkilediği belirtilmektedir. 

Anahtar Kelimeler

Bariatrik cerrahi, mikrobiyota, mikroorganizmalar

Kaynakça

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