MEDICAL NUTRITION THERAPY APPROACHES IN THE MANAGEMENT OF LYMPHEDEMA
Yıl 2023,
Cilt: 8 Sayı: 3, 53 - 65, 07.01.2024
Hatice Bölükbaşı
,
Yasemin Akdevelioğlu
Öz
Lymphedema is a condition caused by the accumulation of protein-rich fluid in the interstitial space due to inadequate lymph drainage. The most important factors for treatment are preventing the development of lymphedema in the early stages and preventing and slowing down its progression if it has developed. Successful treatment of lymphedema requires a long and challenging process and requires a multidisciplinary approach. Nutrition is one of the main components in the therapeutic management of vascular diseases. It is thought that dietary therapies that provide ideal body weight control, support intestinal health, prevent the development of edema, prevent overload increase in the lymphatic system, and support the immune system can be considered one of the treatment components of disease management. This review aims to examine the results of the studies in the literature on the nutritional treatment of lymphedema.
Kaynakça
- REFERENCES
1. Vural SP. Self-Bandaging in Lower Extremity Lymphedema. Türkiye Clinics Physical Medicine and Rehabilitation-Special Topics. 2016;9(4):110-5.
- 2. Toktaş H, Çevik H, Dündar Ü, Güleç Ö. Lymphedema treatment. Kocatepe Medical Journal. 2015;16(4):269-72.
- 3. Balevi Batur E. Lymphedema Rehabilitation. Sedef AM, Güler OC (Ed.) Academician. 2020 p:213-20. ISBN: ISBN-13 (15) 978-605-258-954-0
- 4. Warren AG, Brorson H, Borud LJ, Slavin SA. Lymphedema: a comprehensive review. Annals of Plastic Surgery. 2007;59(4):464-72.
- 5. Borman P. Lymphedema diagnosis, treatment, and follow-up from the viewpoint of physical medicine and rehabilitation specialists. Turkish Journal of Physical Medicine and Rehabilitation. 2018;64(3):179.
- 6. Ünlü Z. Epidemiology of the Lymphedema Turkiye Clinics J PM&R-Special Topics. 2016;9(4):14-8.
- 7. Turna IF. Current Overview of Lymphedema Diagnosis and Treatment. Acıbadem University Journal of Health Sciences. 2020(1):14-22.
- 8. Grada AA, Phillips TJ. Lymphedema: Pathophysiology and clinical manifestations. Journal of the American Academy of Dermatology. 2017;77(6):1009-20.
- 9. Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. The American Journal of Surgery. 2004;187(1):69-72.
- 10. Kebudi A, Uludağ M, Yetkin G, Çitgez B, İşgör A. Lymphedema after modified radical mastectomy in the treatment of breast cancer: incidence and risk factors. Journal of Breast Health. 2005;1(1):1-5.
- 11. Meric F, Buchholz TA, Mirza NQ, Vlastos G, Ames FC, Ross MI. Long-term complications associated with breast-conservation surgery and radiotherapy. Annals of surgical oncology. 2002;(9):543-9.
- 12. Kaplan E, Avcı EE. Prevention Of Lymphedema After Breast Cancer Surgery and Multidisciplinary Approach in Its Treatment. III. International Congress of Vocational and Technical Sciences Full Textbook;2018. p:3554-59.
- 13. Keser İ. Lymphedema Treatment. Pelikan Publishing, 2022. p:131.
- 14. Özdemir ÖÇ, Yildirim B, Ebru K. Alternative Treatment Methods in Lymphedema. Izmir Democracy University Health Sciences Journal.3(1):1-7.
- 15. Pervane Vural S. Self-Bandaging in the Lower Extremity Lymphedema. Turkiye Klinikleri J PM&R-Special Topics. 2016;9(4):110-5.
- 16. Bellomo R, Buda R, Porreca A, Virgili E, Postacchini G, Bacci PA, et al. Treatment of lymphedema, two methods compared: Ketogenic diet and Endospheres, Ketogenic diet and Vodder lymphatic drainage. Journal of Applied Cosmetology. 2022;40(1):54/68-54/68.
- 17. Tenkorang GO, Amewu EKA, Asiedu SO, Kini P, Aglomasa BC, Koranteng K, et al. Poor Nutritional Status Among Human Filarial Lymphedema Patients in Ghana: A Cross-Sectional Study. 2021.
- 18. Greene AK.(eds.) LP, Diagnosis, and Treatment, DOI 10.1007/978-3-319-14493-1_17, © Springer International Publishing Switzerland 2015 p:209.
- 19. Tavares T, Vann V. Cancer-Related Lymphedema Management: Development of Patient Education Resources. Plastic and Aesthetic Nursing. 2022;42(2):99-102.
- 20. Zuther JE. Lymphedema management: the comprehensive guide for practioners. 2005.
- 21. Ehrlich C, Iker E, Herbst KL, Kahn L-A, Sears DD, Kenyon M, et al. Lymphedema and Lipedema Nutrition Guide: foods, vitamins, minerals, and supplements: Lymph Notes; 2016.
- 22. Treves N. An evaluation of the etiological factors of lymphedema following radical mastectomy. An analysis of 1,007 cases. Cancer. 1957;10(3):444-59.
- 23. Helyer LK, Varnic M, Le LW, Leong W, McCready D. Obesity is a risk factor for developing postoperative lymphedema in breast cancer patients. The breast journal. 2010;16(1):48-54.
- 24. Savetsky IL, Torrisi J, Cuzzone D, Ghanta S, Albano N, Gardenier JC, et al. Obesity worsens lymphedema via an exaggerated inflammatory response. Journal of the American College of Surgeons. 2014;219(4):e135.
- 25. Choi J, Kim J, Kim J, Jeong W, Jo T, Lee HW, et al. A high-fat diet in the absence of obesity increases lymphangiogenesis by inducing VEGF-C in a murine lymphedema model. Plastic and Reconstructive Surgery. 2023;152(1):87-96.
- 26. Gousopoulos E, Karaman S, Proulx ST, Leu K, Buschle D, Detmar M. High-fat diet in the absence of obesity does not aggravate surgically induced lymphoedema in mice. European surgical research. 2017;58(3-4):180-92.
- 27. Kim C, Lee S, Kim Y, Kim B, Choi H, Kawada T, et al. Visceral fat accumulation induced by a high‐fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity. 2008;16(6):1261-9.
- 28. Weitman ES, Aschen SZ, Farias-Eisner G, Albano N, Cuzzone DA, Ghanta S, et al. Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PloS one. 2013;8(8):e70703.
- 29. Castorena-Gonzalez JA. Lymphatic valve dysfunction in western diet-fed mice: New insights into obesity-induced lymphedema. Frontiers in pharmacology. 2022; 13:823266.
- 30. Greene AK, Maclellan RA. Obesity-induced upper extremity lymphedema. Plastic and Reconstructive Surgery Global Open. 2013;1(7).
- 31. Mehrara BJ, Greene AK. Lymphedema and obesity: is there a link? Plastic and reconstructive surgery. 2014;134(1):154e.
- 32. Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low‐fat diet with a weight‐reduction diet in breast cancer‐related lymphedema. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2007;109(10):1949-56.
- 33. Shaw C, Mortimer P, Judd PA. A randomized controlled trial of weight reduction as a treatment for breast cancer‐related lymphedema. Cancer. 2007;110(8):1868-74.
- 34. Keith L, Rowsemitt C, Richards LG. Lifestyle modification group for lymphedema and obesity results in significant health outcomes. American Journal of Lifestyle Medicine. 2020;14(4):420-8.
- 35. Hoffmann A, Kleniewska P, Pawliczak R. Antioxidative activity of probiotics. Archives of Medical Science: AMS. 2021;17(3):792.
- 36. Navaei M, Haghighat S, Janani L, Vafa S, Saneei Totmaj A, Raji Lahiji M, et al. The effects of synbiotic supplementation on antioxidant capacity and arm volumes in survivors of breast cancer-related lymphedema. Nutrition and cancer. 2020;72(1):62-73.
- 37. Vafa S, Zarrati M, Malakootinejad M, Totmaj AS, Zayeri F, Salehi M, et al. Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial. The Breast. 2020;54:37-45.
- 38. Cavezzi A, Urso SU, Ambrosini L, Croci S, Campana F, Mosti G. Lymphedema and nutrition: A review. Veins and Lymphatics. 2019;8(1).
- 39. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010 Aug;68(8):439-58.
40. Zuther J. Fluid and Sodium for Lymphedema. available at: https://www.lymphedemablog.com/2022/07/04/fluid-and-sodium-for-lymphedema/.26.09.2023
- 41. Türkiye Nutrition Guide (TÜBER)-2022. T.R. Ministry of Health Publication No: 1031, Ankara 2022.
- 42. Coetzee O, Filatova D. Lipidema and Lymphedema: the. Leaky Lymph,” Weight Loss Resistance and the Intestinal Permeability Connection” EC Nutrition. 2017;11:233-43.
- 43. Blum KS, Karaman S, Proulx ST, Ochsenbein AM, Luciani P, Leroux J-C, et al. Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PloS one. 2014;9(4):e94713.
- 44. Wang L, Zhen M, Li H, Yan H, Jiang B, Wiley JA, et al. Effects of dietary habits and catheterization type on breast cancer-related lymphedema: a retrospective cohort study. 2022.
- 45. Ryu E, Yim SY, Do HJ, Lim J-Y, Yang EJ, Shin M-J, et al. Risk of secondary lymphedema in breast cancer survivors is related to serum phospholipid fatty acid desaturation. Supportive Care in Cancer. 2016;24:3767-74.
- 46. Oliveira J, Cesar T. Influence of complex descongestive physical therapy associated with intake of medium-chain triglycerides for treating upper-limb lymphedema. Brazilian Journal of Physical Therapy. 2008;12:31-6.
- 47. Fink A, Kaltenegger I, Schneider B, Fruhauf J, Jurecka W, Steiner A. Serum level of VEGF-D in patients with primary lymphedema. Lymphology. 2004;37(4):185-9.
- 48. Saaristo A, Karkkainen MJ, Alitalo K. Insights into the molecular pathogenesis and targeted treatment of lymphedema. Annals of the New York Academy of Sciences. 2002;979(1):94-110.
- 49. Saneei Totmaj A, Haghighat S, Jaberzadeh S, Navaei M, Vafa S, Janani L, et al. The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial. Nutrition and Cancer. 2022;74(3):869-81.
- 50. Schmitz KH, Troxel AB, Dean LT, DeMichele A, Brown JC, Sturgeon K, et al. Effect of home-based exercise and weight loss programs on breast cancer–related lymphedema outcomes among overweight breast cancer survivors: The WISER Survivor randomized clinical trial. JAMA oncology. 2019;5(11):1605-13.
LENFÖDEM YÖNETİMİNDE TIBBİ BESLENME TEDAVİSİ YAKLAŞIMLARI
Yıl 2023,
Cilt: 8 Sayı: 3, 53 - 65, 07.01.2024
Hatice Bölükbaşı
,
Yasemin Akdevelioğlu
Öz
Lenfödem; lenf drenajındaki yetersizlik sonucunda proteinden zengin sıvının interstisyel alanda birikimi ile oluşan bir durumdur. Lenfödemin ilk evrelerde gelişiminin önlenmesi, gelişmiş ise ilerlemesinin engellenmesi ve yavaşlatılması tedavi için en önemli unsurlardandır. Uzun ve zor bir süreç gerektiren lenfödem tedavisinin başarılı olabilmesi multidisipliner bir yaklaşım gerektirmektedir. Beslenme, damar hastalıklarının terapötik yönetiminde temel bileşenlerden biridir. İdeal vücut ağırlığı kontrolü sağlayan, bağırsak sağlığını destekleyen, ödem gelişimini önleyici, lenfatik sistemdeki aşırı yük artışını engelleyici ve immün sistemi destekleyici diyet tedavilerinin hastalık yönetiminin tedavi bileşenlerinden biri olarak kabul edilebileceği düşünülmektedir. Bu derlemede lenfödemin beslenme tedavisine yönelik literatürde yer alan çalışma sonuçlarını incelemek amaçlanmıştır.
Kaynakça
- REFERENCES
1. Vural SP. Self-Bandaging in Lower Extremity Lymphedema. Türkiye Clinics Physical Medicine and Rehabilitation-Special Topics. 2016;9(4):110-5.
- 2. Toktaş H, Çevik H, Dündar Ü, Güleç Ö. Lymphedema treatment. Kocatepe Medical Journal. 2015;16(4):269-72.
- 3. Balevi Batur E. Lymphedema Rehabilitation. Sedef AM, Güler OC (Ed.) Academician. 2020 p:213-20. ISBN: ISBN-13 (15) 978-605-258-954-0
- 4. Warren AG, Brorson H, Borud LJ, Slavin SA. Lymphedema: a comprehensive review. Annals of Plastic Surgery. 2007;59(4):464-72.
- 5. Borman P. Lymphedema diagnosis, treatment, and follow-up from the viewpoint of physical medicine and rehabilitation specialists. Turkish Journal of Physical Medicine and Rehabilitation. 2018;64(3):179.
- 6. Ünlü Z. Epidemiology of the Lymphedema Turkiye Clinics J PM&R-Special Topics. 2016;9(4):14-8.
- 7. Turna IF. Current Overview of Lymphedema Diagnosis and Treatment. Acıbadem University Journal of Health Sciences. 2020(1):14-22.
- 8. Grada AA, Phillips TJ. Lymphedema: Pathophysiology and clinical manifestations. Journal of the American Academy of Dermatology. 2017;77(6):1009-20.
- 9. Ozaslan C, Kuru B. Lymphedema after treatment of breast cancer. The American Journal of Surgery. 2004;187(1):69-72.
- 10. Kebudi A, Uludağ M, Yetkin G, Çitgez B, İşgör A. Lymphedema after modified radical mastectomy in the treatment of breast cancer: incidence and risk factors. Journal of Breast Health. 2005;1(1):1-5.
- 11. Meric F, Buchholz TA, Mirza NQ, Vlastos G, Ames FC, Ross MI. Long-term complications associated with breast-conservation surgery and radiotherapy. Annals of surgical oncology. 2002;(9):543-9.
- 12. Kaplan E, Avcı EE. Prevention Of Lymphedema After Breast Cancer Surgery and Multidisciplinary Approach in Its Treatment. III. International Congress of Vocational and Technical Sciences Full Textbook;2018. p:3554-59.
- 13. Keser İ. Lymphedema Treatment. Pelikan Publishing, 2022. p:131.
- 14. Özdemir ÖÇ, Yildirim B, Ebru K. Alternative Treatment Methods in Lymphedema. Izmir Democracy University Health Sciences Journal.3(1):1-7.
- 15. Pervane Vural S. Self-Bandaging in the Lower Extremity Lymphedema. Turkiye Klinikleri J PM&R-Special Topics. 2016;9(4):110-5.
- 16. Bellomo R, Buda R, Porreca A, Virgili E, Postacchini G, Bacci PA, et al. Treatment of lymphedema, two methods compared: Ketogenic diet and Endospheres, Ketogenic diet and Vodder lymphatic drainage. Journal of Applied Cosmetology. 2022;40(1):54/68-54/68.
- 17. Tenkorang GO, Amewu EKA, Asiedu SO, Kini P, Aglomasa BC, Koranteng K, et al. Poor Nutritional Status Among Human Filarial Lymphedema Patients in Ghana: A Cross-Sectional Study. 2021.
- 18. Greene AK.(eds.) LP, Diagnosis, and Treatment, DOI 10.1007/978-3-319-14493-1_17, © Springer International Publishing Switzerland 2015 p:209.
- 19. Tavares T, Vann V. Cancer-Related Lymphedema Management: Development of Patient Education Resources. Plastic and Aesthetic Nursing. 2022;42(2):99-102.
- 20. Zuther JE. Lymphedema management: the comprehensive guide for practioners. 2005.
- 21. Ehrlich C, Iker E, Herbst KL, Kahn L-A, Sears DD, Kenyon M, et al. Lymphedema and Lipedema Nutrition Guide: foods, vitamins, minerals, and supplements: Lymph Notes; 2016.
- 22. Treves N. An evaluation of the etiological factors of lymphedema following radical mastectomy. An analysis of 1,007 cases. Cancer. 1957;10(3):444-59.
- 23. Helyer LK, Varnic M, Le LW, Leong W, McCready D. Obesity is a risk factor for developing postoperative lymphedema in breast cancer patients. The breast journal. 2010;16(1):48-54.
- 24. Savetsky IL, Torrisi J, Cuzzone D, Ghanta S, Albano N, Gardenier JC, et al. Obesity worsens lymphedema via an exaggerated inflammatory response. Journal of the American College of Surgeons. 2014;219(4):e135.
- 25. Choi J, Kim J, Kim J, Jeong W, Jo T, Lee HW, et al. A high-fat diet in the absence of obesity increases lymphangiogenesis by inducing VEGF-C in a murine lymphedema model. Plastic and Reconstructive Surgery. 2023;152(1):87-96.
- 26. Gousopoulos E, Karaman S, Proulx ST, Leu K, Buschle D, Detmar M. High-fat diet in the absence of obesity does not aggravate surgically induced lymphoedema in mice. European surgical research. 2017;58(3-4):180-92.
- 27. Kim C, Lee S, Kim Y, Kim B, Choi H, Kawada T, et al. Visceral fat accumulation induced by a high‐fat diet causes the atrophy of mesenteric lymph nodes in obese mice. Obesity. 2008;16(6):1261-9.
- 28. Weitman ES, Aschen SZ, Farias-Eisner G, Albano N, Cuzzone DA, Ghanta S, et al. Obesity impairs lymphatic fluid transport and dendritic cell migration to lymph nodes. PloS one. 2013;8(8):e70703.
- 29. Castorena-Gonzalez JA. Lymphatic valve dysfunction in western diet-fed mice: New insights into obesity-induced lymphedema. Frontiers in pharmacology. 2022; 13:823266.
- 30. Greene AK, Maclellan RA. Obesity-induced upper extremity lymphedema. Plastic and Reconstructive Surgery Global Open. 2013;1(7).
- 31. Mehrara BJ, Greene AK. Lymphedema and obesity: is there a link? Plastic and reconstructive surgery. 2014;134(1):154e.
- 32. Shaw C, Mortimer P, Judd PA. Randomized controlled trial comparing a low‐fat diet with a weight‐reduction diet in breast cancer‐related lymphedema. Cancer: Interdisciplinary International Journal of the American Cancer Society. 2007;109(10):1949-56.
- 33. Shaw C, Mortimer P, Judd PA. A randomized controlled trial of weight reduction as a treatment for breast cancer‐related lymphedema. Cancer. 2007;110(8):1868-74.
- 34. Keith L, Rowsemitt C, Richards LG. Lifestyle modification group for lymphedema and obesity results in significant health outcomes. American Journal of Lifestyle Medicine. 2020;14(4):420-8.
- 35. Hoffmann A, Kleniewska P, Pawliczak R. Antioxidative activity of probiotics. Archives of Medical Science: AMS. 2021;17(3):792.
- 36. Navaei M, Haghighat S, Janani L, Vafa S, Saneei Totmaj A, Raji Lahiji M, et al. The effects of synbiotic supplementation on antioxidant capacity and arm volumes in survivors of breast cancer-related lymphedema. Nutrition and cancer. 2020;72(1):62-73.
- 37. Vafa S, Zarrati M, Malakootinejad M, Totmaj AS, Zayeri F, Salehi M, et al. Calorie restriction and synbiotics effect on quality of life and edema reduction in breast cancer-related lymphedema, a clinical trial. The Breast. 2020;54:37-45.
- 38. Cavezzi A, Urso SU, Ambrosini L, Croci S, Campana F, Mosti G. Lymphedema and nutrition: A review. Veins and Lymphatics. 2019;8(1).
- 39. Popkin BM, D'Anci KE, Rosenberg IH. Water, hydration, and health. Nutr Rev. 2010 Aug;68(8):439-58.
40. Zuther J. Fluid and Sodium for Lymphedema. available at: https://www.lymphedemablog.com/2022/07/04/fluid-and-sodium-for-lymphedema/.26.09.2023
- 41. Türkiye Nutrition Guide (TÜBER)-2022. T.R. Ministry of Health Publication No: 1031, Ankara 2022.
- 42. Coetzee O, Filatova D. Lipidema and Lymphedema: the. Leaky Lymph,” Weight Loss Resistance and the Intestinal Permeability Connection” EC Nutrition. 2017;11:233-43.
- 43. Blum KS, Karaman S, Proulx ST, Ochsenbein AM, Luciani P, Leroux J-C, et al. Chronic high-fat diet impairs collecting lymphatic vessel function in mice. PloS one. 2014;9(4):e94713.
- 44. Wang L, Zhen M, Li H, Yan H, Jiang B, Wiley JA, et al. Effects of dietary habits and catheterization type on breast cancer-related lymphedema: a retrospective cohort study. 2022.
- 45. Ryu E, Yim SY, Do HJ, Lim J-Y, Yang EJ, Shin M-J, et al. Risk of secondary lymphedema in breast cancer survivors is related to serum phospholipid fatty acid desaturation. Supportive Care in Cancer. 2016;24:3767-74.
- 46. Oliveira J, Cesar T. Influence of complex descongestive physical therapy associated with intake of medium-chain triglycerides for treating upper-limb lymphedema. Brazilian Journal of Physical Therapy. 2008;12:31-6.
- 47. Fink A, Kaltenegger I, Schneider B, Fruhauf J, Jurecka W, Steiner A. Serum level of VEGF-D in patients with primary lymphedema. Lymphology. 2004;37(4):185-9.
- 48. Saaristo A, Karkkainen MJ, Alitalo K. Insights into the molecular pathogenesis and targeted treatment of lymphedema. Annals of the New York Academy of Sciences. 2002;979(1):94-110.
- 49. Saneei Totmaj A, Haghighat S, Jaberzadeh S, Navaei M, Vafa S, Janani L, et al. The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer with Lymphedema following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial. Nutrition and Cancer. 2022;74(3):869-81.
- 50. Schmitz KH, Troxel AB, Dean LT, DeMichele A, Brown JC, Sturgeon K, et al. Effect of home-based exercise and weight loss programs on breast cancer–related lymphedema outcomes among overweight breast cancer survivors: The WISER Survivor randomized clinical trial. JAMA oncology. 2019;5(11):1605-13.