Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler

Sahra Setenay Baran; Belma Aslım

doi:10.5281/zenodo.4317954

Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler

Öz

Neurodegenerative disorders are results of structural and functional dysfunction of the nervous system. Although there are several therapeutic approaches for these diseases, these approaches cannot be effective in pathological processes and are applied only palliative. For this reason, new compounds for neurodegenerative diseases are crucial. Calcium (Ca2+) which acts as a second messenger, is required for neuronal activity as well as for many biological activities. The pivotal role of Ca2+ homeostasis has long been recognized in hypertension and cardiovascular disease. Ca2+ channel blockers have been commonly prescribed for treatment of the hypertension and cardiovascular diseases because of their mechanism of action due to reducing the influx of Ca2+ . Disruptions in the intracellular Ca2+ homeostasis play a central role in the pathophysiology of neurodegenerative diseases such as Alzheimer and Parkinson. Channel blockers may be effective in neurodegenerative diseases. In this review, we aimed to review the relationship between the metabolism of neurodegenerative diseases and Ca2+ dyshomeostasis and to reveal natural compounds, which have therapeutic effects in neurodegenerative diseases, with modulation of Ca2+ homeostasis. Evolution of their potentials for drug candidates represents an important step for the prevention of neurodegeneration and for molecular mechanisms of Ca2+ homeostasis disorders.

Anahtar Kelimeler

Kaynakça

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Ayrıntılar

Birincil Dil

Türkçe

Konular

-

Bölüm

Derleme

Yazarlar

Sahra Setenay Baran ^* Bu kişi benim
Türkiye

Belma Aslım
Türkiye

Yayımlanma Tarihi

30 Aralık 2020

Gönderilme Tarihi

5 Kasım 2020

Kabul Tarihi

5 Aralık 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 1 Sayı: 1-2

DOI

https://doi.org/10.5281/zenodo.4317954

IZ

https://izlik.org/JA77WB53NX

Kaynak Göster

RIS / Bibtex

APA

Baran, S. S., & Aslım, B. (2020). Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler. Gazi Üniversitesi Fen Fakültesi Dergisi, 1(1-2), 36-50. https://doi.org/10.5281/zenodo.4317954

AMA

1.Baran SS, Aslım B. Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler. GÜFFD. 2020;1(1-2):36-50. doi:10.5281/zenodo.4317954

Chicago

Baran, Sahra Setenay, ve Belma Aslım. 2020. “Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler”. Gazi Üniversitesi Fen Fakültesi Dergisi 1 (1-2): 36-50. https://doi.org/10.5281/zenodo.4317954.

EndNote

Baran SS, Aslım B (01 Aralık 2020) Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler. Gazi Üniversitesi Fen Fakültesi Dergisi 1 1-2 36–50.

IEEE

[1]S. S. Baran ve B. Aslım, “Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler”, GÜFFD, c. 1, sy 1-2, ss. 36–50, Ara. 2020, doi: 10.5281/zenodo.4317954.

ISNAD

Baran, Sahra Setenay - Aslım, Belma. “Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler”. Gazi Üniversitesi Fen Fakültesi Dergisi 1/1-2 (01 Aralık 2020): 36-50. https://doi.org/10.5281/zenodo.4317954.

JAMA

1.Baran SS, Aslım B. Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler. GÜFFD. 2020;1:36–50.

MLA

Baran, Sahra Setenay, ve Belma Aslım. “Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler”. Gazi Üniversitesi Fen Fakültesi Dergisi, c. 1, sy 1-2, Aralık 2020, ss. 36-50, doi:10.5281/zenodo.4317954.

Vancouver

1.Sahra Setenay Baran, Belma Aslım. Nörodejeneratif Hastalıkların Ca+2 Homeostazisi ile İlişkisi ve Ca+2 Homeostazisinin Düzenlenmesini Hedef Alan Doğal Bileşenler. GÜFFD. 01 Aralık 2020;1(1-2):36-50. doi:10.5281/zenodo.4317954