Development of a PEDOT nanowire-modified pencil graphite electrode for the electrochemical determination of 5-Fluorouracil

Abstract

An electrochemical sensor based on a pencil graphite electrode (PGE) coated with poly(3,4-ethylenedioxythiophene) nanowires (PEDOT NWs) was developed for the detection of 5-Fluorouracil (5-FU). The PEDOT NWs were electrodeposited onto the surface of the PGE as a modifier. PGE/PEDOT NWs exhibited a remarkable increment in anodic peak current corresponding to the electrochemical oxidation of 5-FU. The investigation of oxidation peaks in buffer solutions at varying pH levels indicated that the measured current values ​​allowed the determination of the optimal pH, which was found to be 7. The PEDOT nanowire-modified electrode demonstrated effective detection of 5-FU, with a limit of detection (LOD) of 0.80 µmol L^–1 and a linear response range of 4-100 µmol L^–1. In this study, the specificity of the designed electrochemical sensor platform was evaluated in the presence of various electroactive species.

Keywords

• Poly(3,4-ethylenedioxythiophene)
• 5-Fluorouracil
• Electrochemical sensor
• Pencil graphite electrode
• Differential pulse voltammetry

5-Florourasil'in elektrokimyasal tayini için PEDOT nanotel-modifiye kalem grafit elektrot geliştirilmesi

Abstract

5-Florourasil (5-FU) tayini için yeni bir elektrokimyasal sensör, poli(3,4-etilendioksitiyofen) nanotel (PEDOT NWs) kaplı kalem grafit elektrot (PGE) kullanılarak geliştirilmiştir. PEDOT NWs, bir modifiye edici olarak PGE yüzeyine elektrokaplanmıştır. PGE/PEDOT NWs, 5-FU'nun elektrokimyasal yükseltgenmesine karşılık gelen anodik pik akımında dikkate değer bir artış göstermiştir. Değişen pH seviyelerinde tampon çözeltilerdeki yükseltgenme pikinin incelenmesi, ölçülen akım değerlerinin pH 7 olarak bulunan optimum pH'ın belirlenmesine izin verdiğini göstermiştir. PEDOT NWs ile modifiye edilmiş elektrot, 0,80 µmol L–1'lik bir gözlenebilme sınırı (LOD) ve 4-100 µmol L–1'lik doğrusal bir aralık göstererek 5-FU tayini için etkili olmuştur. Bu çalışmada, tasarlanan elektrokimyasal sensör platformunun özgüllüğü çeşitli elektroaktif türlerin varlığında değerlendirilmiştir.

Keywords

• Poli(3,4-etilendioksitiyofen)
• 5-Florourasil
• elektrokimyasal sensor
• kalem grafit elektrot
• diferansiyel puls voltametri

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