Adverse Effects of Lead Treatment: Relationship of Histopathological Changes and Protective Role of Sodium Selenite on Non-Diabetic and Diabetic Rat Hearts

Abstract

The present study was designed to examine the effects of lead nitrate (LN) and whether selenium has a cardioprotective effect on diabetic and non-diabetic rats. Sodium and LN were administered orally for 28 days to streptozotocin-induced diabetic and non-diabetic rats. Animals were divided into 8 groups: control, sodium selenite, LN, LN+Sodium selenite, diabetic-control, diabetic sodium selenite, diabetic LN and diabetic LN+Sodium selenite. In our present study LN caused histopathological changes in heart of animals. In the present study we found that sodium selenite treatment did not show protective effect on DM caused damages but, although not completely shown a protective.

 

Keywords

• Lead toxicity
• sodium selenite
• diabetes mellitus
• histopathology
• hearth

References

1. El-Naggar, A.M,. Mahmoud, S.A. Tayel, S.I., “Bioaccumulation histopathological alterations in liver of Oreochromis niloticus in relation to water quality at different localities along the river nile, Egypt”, WJFMS. 1 (2): 105–114, (2009). heavy metals and FAO, “Committee for inland fisheries of Africa;
2. Report of the third session of the working party on pollution and fisheries”, FAO fisheries. Rep., No. 471, (1992).
3. Zbakh, H., Abbassi, A.E., “Potential use of olive mill wastewater in the preparation of functional beverages: a review”. J. Funct. Food, 4: 450–458 (2012). Dewanjee,
4. Gangopadhyay, M., “Toxic effects of lead exposure in Wistar rats: Involvement of oxidative stress and the beneficial role of edible jute (Corchorus olitorius) leaves”, Food Chem. Toxicol. 55: 78–91 (2013). S.,
5. Voors, A.W., Shuman, M.S., Johnson, W.D., “Additive statistical effects of cadmium and lead on heart-related disease in a North Carolina autopsy series”. Arch. Environ. Health, 37: 98–102 (1982).
6. Bellinger, D.C., “Very low lead exposures and children’s neurodevelopment”. Curr. Opin. Pediatr. 20: 172–177 (2008).
7. Rosenberg, C.E., Fink, N.E., Salibian, A., “Humoral immune alterations caused by lead: studies on an adult toad model”. Acta Toxicol. Arg. 15: 16–23 (2007).
8. Rastogi, S.K., “Renal effects of environmental and occupational lead exposure”. Ind. J. Occup. Env. Med. 12: 103–106 (2008).

9. Khalid, G., Fartosi, A.L., “Effect of selenium and lead on some blood parameters of male mice”. J. Dohuk Univ. 11: 62–66 (2008).
10. Kaur, P., Evje, L., Aschner, M., Syversen, T., “The in vitro effects of selenomethionine on methylmercury- induced neurotoxicity”, Toxicol. in Vitro, 23: 378–385 (2009).
11. World Health Organisation, “Environmental Health Criteria 58: Selenium” International Programme on Chemical Safety, Geneva. (1987).
12. Luo, Y., Zhang, B., Cheng, W., Wang, Q., “Preparation, characterization and evaluation of selenite-loaded chitosan/TPP nanoparticles with or without zein coating”. Carbohyd. Polym. 82: 942–951 (2010). Kalender,
13. Uzunhisarcıklı, M., Aslanturk, A., “Mercuric chloride- induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E”, Food Chem.Toxicol. 55: 456–462 (2013). F.G., Demir, F.,
14. Orun, I., Talas, Z.S, Ozdemir, I., Alkan, A., Erdogan, K., “Antioxidative role of selenium on some tissues of (Cd2+, Cr3+)-induced rainbow trout”, Ecotoxicol. Environ. Safe. 71: 71–75 (2008).
15. Altan, V.M., “The pharmacology of diabetic complications”, Curr. Med. Chem. 10: 1317–27 (2003).
16. Al-Khalifa, A., Mathew, T.C., Al-Zaid, N.S., Mathew, E., Dashti, H., “Low carbohydrate ketogenic diet prevents the induction of diabetes using streptozotocin in rats”, Exp. Toxicol. Pathol. 63: 663– 669 (2011).
17. Thirunavukkarasu, M., Penumathsa, S.V., Koneru, S., Juhasz, B., Zhan, L., Otani, H., Bagchi, D., Das, D.K., Maulik, N., “Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase”, Free Radical Bio. Med. 43: 720–729 (2007). Abbott,
18. Kannel,W.B.;Wilson, P.W., “The impact of diabetes on survival following myocardial infarction in men vs women: the Framingham Study” JAMA 260: 3456– 3460 (1988). Donahue, R.P.;
19. Ayaz, M., Turan, B., “Selenium prevents diabetes- induced alterations in [Zn2+]i and metallothionein level of rat heart via restoration of cell redox cycle”, Am J Physiol Heart Circ Physiol 290: H1071-H1080 (2006).
20. Sharma, V., Sharma, A., Kansal, L., “The effect of oral administration of Allium sativum extracts on lead nitrate induced toxicity in male mice”, Food Chem. Toxicol. 48: 928-936 (2010).
21. Othman, A.I., El Missiry, M.A., “The role of selenium against lead toxicity in male rats”, J. Biochem. Mol. Toxicol. 12: 345-349 (1998).
22. Plastunov, B., Zub, S.,. “Lipid peroxidation processes intoxication and iodine-deficient in experiment”, Anales Universitatis Mariae Curie Sklodowska Lublin-pol. 21: 215-217 (2008). defense under lead
23. Schmatz, R., Melazzo Mazzanti, C., Spanevello, R., Stefanello, N., Gutierres, J., Corrêa, M., Melgarejo da Rosa, M., Rubin, M.A., Schetinger, M.R.C., Morsch, V.M., “Resveratrol prevents memory deficits and the increase streptozotocin-induced Pharmacol. 610: 42-48 (2009). activity in J. diabetic rats”, Eur. activated mitogen protein kinases”,
24. Franco, R., Sánchez-Olea, R., Reyes-Reyes, E.M., Panayiotidis, M.I., “Environmental toxicity, oxidative stress and apoptosis: Ménage à Trois”, Mutat. Res. 674: 3–22 (2009).
25. Mana, P., Sinha, M., Sil, P.C., “Amelioration of cadmium-induced cardiac impairment by taurine”, Chem. Biol. Interact. 174: 88–97 (2008).
26. Lakshmi, B.V.S., Sudhakar, M., Aparna, M., “Protective potential of Black grapes against lead induced oxidative stress in rats”, Environ. Toxicol. Pharmacol. 35: (361–368 (2013).
27. Soudani, N., Troudi, A., Bouaziz, H.,Amara, I.B., Boudawara, T., Zeghal, N., “Cardioprotective effects of selenium on chromium (VI) -induced toxicity in female rats”, Ecotoxicol. Environ. Safe. 74: 513-520 (2011).
28. Assis, G.P.S., Silva, C.E.C., Stefanon, I., Vassallo, D.V., “Effects of small concentrations of mercury on the contractile activity of the rat ventricular myocardium”, Comp. Biochem. Physiol., 134: 375–383 (2003).
29. Machado, A.C., Padilha, A.S., Wiggers, G.A., Siman, F.D.M., Stefanon, I., Vassallo, D.V., “Small doses of mercury increase arterial pressure reactivity to phenylephrine in rats”, Environ. Toxicol. Pharmacol., 24: 92–97 (2007).