ONE-POT SYNTHESIS OF 2-AMINO-4H-PYRANS AND 2-AMINO-TETRAHYDRO-4H-CHROMENES USING L-PROLINE

Abstract

A one-pot procedure for the synthesis of 2-amino-4-aryl-4H-pyrans and 2-amino-tetrahydro-4H-chromenes via the multi-component reaction between aryl aldehydes, β-dicarbonyl compounds and malononitrile in the presence of L-proline-in ethanol under reflux conditions has been developed rapidly and smoothly in good to excellent yields.

Keywords

• multicomponent; L-proline; 2-amino-4H-pyrans; chromenes; synthesis

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