Synthesis of N-(Aryl)-2-(phenylselanyl)acetamides and Their Antimicrobial Activities

Year 2016, Volume: 29 Issue: 2, 309 - 315, 20.06.2016

Yılmaz Yıldırır Serkan Yavuz Hamdi Özkan Özge Gürel

Abstract

Novel N-(aryl)-2-(phenylselanyl)acetamides (5a -5l, 6, 7) were synthesized by the reaction of 2-(phenylselanyl)acetyl chloride with substitute arylamine derivatives in dry benzene.  The structures of these compounds were characterized by the spectroscopic methods such as FT-IR, ¹H-NMR, ¹³C NMR and HRMS. Furthermore, all the synthesized compounds were tested in vitro for their antimicrobial and antifungal activity. The obtained results were compared with conventional reference antibiotics Ciprofloxacin and Griseofulvin's results. Their antioxidant potentials were evaluated using in vitro antioxidant models known as DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activities. Some of the tested compounds exhibited significant antibacterial, antifungal and antioxidant activities. Particularly, compound 5h showed more pronounced activity than reference antibiotics against Staphylococcus aureus. Compounds 5f and 5i showed excellent levels of antifungal activity against Penicillium roquefortii and Aspergillus niger. All the compounds showed moderate antioxidant activities.

Keywords

Selenium, antibacterial activity, antifungal activity, antioxidant activity, DPPH

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