Synthesis of New Ligands Containing Azomethine Group and Investigation of Antioxidant, Antiurease Activities

Year 2020, Volume: 33 Issue: 3, 662 - 671, 01.09.2020

Nurhan Gümrükçüoğlu , Bahar Bilgin Sökmen

https://doi.org/10.35378/gujs.615818

Cited By: 1

Abstract

A series of Schiff base ligands containing 1,2,4-triazole ring were obtained by the addition of aldehydes to the amino compound under mild conditions in 80–82% yields. A reduction of these ligands with sodium borohydride resulted in Schiff base reduction products. New ligands were investigated for their antioxidant activities such as DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2’-azino-bis (3-ethylbenzo-thizoline-6-sulphonic acid) diammonium salt) radical scavenging and reducing power. 1H and 13C-NMR spectra (δ, ppm) were observed on a Varian Mercury 200 MHz spectrophotometer as standard substance using tetramethylsilane Match constants (J values) were given as Hertz. NMR coefficients are truncated as follows: s=singlet, d=dublet, t=triplet, m=multiplet signal. Combustion analysis was performed on a Carlo Erba 1106 elemental analyzer. All the compounds gave C, H, and N analysis results within ±0.6 % of the theoretical values. The IR spectra (υ, cm−1) were viewed with a Perkin-Elmer 1600 FTIR spectrometer in KBr pellets. 

Keywords

Antioxidant activity, Azomethine group, Characterization, Ligands, Urease inhibition activity

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