Lead Nitrate Induced Oxidative Stress in Brain Tissues of Rats: Protective Effect of Sodium Selenite

Year 2014, Volume: 27 Issue: 3, 883 - 889, 28.04.2014

Suna Kalender Fatma Apaydın Filiz Demir Hatice Baş

Abstract

Lead used in many industrial applications and it has been recognized as a toxic metal. The aim of this study is to investigate the effects of lead nitrate on brain tissues of diabetic and non-diabetic rats and the protective role of sodium selenite. Four weeks later, changes in antioxidant enzyme activities and MDA levels determined in the brain tissues. At the end of the study, we showed that lead nitrate causes oxidative stress in diabetic and non-diabetic rat brain and the sodium selenite can ameliorate this toxicity, but not protect completely.

Keywords

Lead Nitrate, Sodium selenite, Antioxidant Enzymes, Oxidative stress, Brain

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