Lactobacillus curvatus Suşu ile Asetofenon Türevlerinin Asimetrik İndirgenmesi

Year 2017, Volume: 7 Issue: 2, 285 - 308, 31.07.2017

Engin Şahin

Abstract

Sekiz farklı Lactobacillus curvatus suşu asetofenon’un 1-fenil etanol’e
asimetrik indirgenmesinde biyokatalizör olarak değerlendirildi. Test edilen bu
laktik asit bakteri (LAB) suşları arasında Lactobacillus
curvatus N5 asetofenon’un enantiyoseçici indirgenmesinde en etkili biyokatalizör
olarak bulundu. Optimize edilen reaksiyon şartları altında asetofenon türevleri
% 99 enantiyomerik fazlalığa kadar ilgili kiral sekonder alkollere dönüştürüldü.

Keywords

Lactobacillus curvatus, Biyokatalizör, Enantioseçici indirgenme, Keton, Kiral alkol, Lactobacillus curvatus

Asymmetric Reduction of Acetophenone Derivatives by a Lactobacillus curvatus strain

Abstract

Eight strains of Lactobacillus
curvatus were evaluated as biocatalysts in the
asymmetric reduction of acetophenone to 1-phenyl ethanol. Among the tested lactic
acid bacteria (LAB) strains Lactobacillus curvatus N5 was found to be an effective biocatalyst for the
enantioselective reduction of acetophenone. Under the optimized reaction
conditions, derivatives of acetophenones were converted to the corresponding
chiral secondary alcohols in up to 99% enantiomeric excess.

Keywords

Biocatalyst, enantioselective reduction, ketone, chiral alcohol, Lactobacillus curvatus

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