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Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması

Year 2018, Volume: 7 Issue: 3, 50 - 56, 30.09.2018

Abstract

Orta Doğu'ya özgü bir meyve olan nar yüz
yıllardır geleneksel tıpta kullanılmaktadır. İn vivo ve in vitro çalışmalara
göre nar ve nar suyu; artırılmış insülin duyarlılığı, a-glukosidazın
inhibisyonu, kolesterolün düşürülmesi ve terapötik hipoglisemik etkilere
sahiptir. Bu bilgiler ışığında bu çalışma narın kan basıncını düşürme üzerine
etkisini belirlemek için yapıldı.



Pubmed, ISI Web of Sciences ve Google
Akademik veri tabanlarında randomize kontrollü klinik araştırmalar araştırıldı.
Meta analize 8 randomize kontrollü çalışma dahil edildi.  Nar uygulamasının bitiminde elde edilen kan
basıncı sonuçları değerlendirmeye alındı. Narın diastolik kan basıncını düşürme
etkisini değerlendirmek için nar ve plasebo grubunun standartlaştırılmış
ortalama fark değeri hesaplandığında; bu değerin -0,255 (95% CI: 56,31-87,96)
olduğu görüldü. Narın sistolik kan basıncını düşürme etkisini değerlendirmek
için nar ve plasebo grubunun standartlaştırılmış ortalama fark değeri hesaplandığında;
bu değerin -0,160 (95% CI: 16,10-80,65) olduğu görüldü.



Bu meta analizin sonucunda Narın sistolik ve
diastolik kan basıncını düşürmede etkili bir yaklaşım olduğu görüldü

References

  • 1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. (2005). Global burden of hypertension: analysis of worldwide data. Lancet, 365(9455), 217-23.2. Hajjar I, Kotchen JM, Kotchen TA. (2006). Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health, 27, 465-90.3. JNC-7 Guidelines. (2003). The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hyper, 42, 1206.4. Lawes CM, Vander Hoorn S, Law MR, Elliott P, MacMahon S, Rodgers A. (2006). Blood pressure and the global burden of disease: part II. Estimates ofattributable burden, J. Hypertens, 24, 423–430.5. DeSimone ME, Crowe A. (2009). Nonpharmacological approaches in the management of hypertension. J Amer Acad N Pract, 21, 189-96.6. Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, Hu FB. (2014). Fruit and vegetableconsumption and mortality from all causes, cardiovascular disease, andcancer: systematic review and dose-response meta-analysis of prospectivecohort studies. BMJ, 349, g44907. Eilat-Adar S, Sinai T, Yosefy C, Henkin Y. (2013). Nutritional recommendations forcardiovascular disease prevention. Nutrients, 5 (9), 3646–3683.8. Grassi D, Desideri G, Ferri C. (2010). Flavonoids: antioxidants againstatherosclerosis, Nutrients, 2 (8), 889–902.9. Gil MI, Toma´s-Barbera´n FA, Hess-Pierce B, Holcroft DM, Kader AA. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem, 48, 4581–4589.10. Basu A and Penugonda K. (2009). Pomegranate juice: a heart-healthy fruit juice. Nutrition Reviews, 67(1), 49–56.11. Shema-Didi L, Sela S, Ore L, Shapiro G, Geron R, Moshe G, et al. (2012). One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial. Free Radic Biol Med, 53, 297–30412. Yoon J-H, Baek SJ. (2005). Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties. Yonsei Medical Journal, 46(5), 585-596. 13. Johanningsmeier SD, Harris GK. (2011). Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol, 2, 181–201.14. Ismail T, Sestili P, Akhtar S. (2012). Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol, 143, 397–405.15. Trottier G, Bostrom PJ, Lawrentschuk N, Fleshner NE. (2010). Nutraceuticals and prostate cancer prevention: a current review. Nat Rev Urol, 7, 21–30.16. Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. (2004). Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food, 7(3), 305–308.17. Tzulker R, Glazer I, Bar-Ilan I, Holland D, Aviram M, Amir R. (2007). Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions. J Agric Food Chem, 55, 9559–9570.18. Rock W, Rosenblat M, Miller-Lotan R, Levy AP, Elias M, Aviram M. (2008). Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. J Agric Food Chem, 56, 8704–8713.19. Jurenka JS. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev, 13, 128–44.20. Medjakovic S, Jungbauer A. (2013). Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct, 4, 19–39.21. Kelishadi R, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P. (2011). Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. J Res Med Sci, 16(3), 245-53. 22. Rosenblat M, Volkova N, Aviram M. (2010). Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2. Atherosclerosis, 212(1), 86–92.23. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. (2004). Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotidintima-media thickness, blood pressure and LDL oxidation. Clin Nutr, 23, 423–33.24. Rosenblat M, Hayek T, Aviram M. (2006). Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis, 187, 363–371.25. Parsaeyan N, Mozaffari-Khosravi H, Mozayan MR. (2012). Effect of pomegranate juice on paraoxonase enzyme activity in patients with type 2 diabetes. J Diabetes Metab Disord, 11(1), 11. 26. Aviram M, Dornfeld L. (2001). Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis, 158, 195–198.27. Razani Z, Dastani M, Kazerani HR. (2017). Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease. Phytother Res, 31, 1731–1738. 28. Moher D, Pham B, Jones A, Cook DJ, Jadad AR, et al. (1998). Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses. Lancet, 352, 609–613.29. Sumner MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, et al. (2005). Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol, 96, 810–814.30. Moazzen H & Alizadeh M. (2017). Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial. Plant Foods Hum Nutr, 72, 126–133.31. Kojadinovic M, Arsic AC, Debeljak-Martacic JD, Konic-Ristic AI, Nevena Dj, Kardum, Popovic TB, Glibetic MD. (2017). Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. J Sci Food Agric, 97, 1798–1804.32. Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME. (2012). Effects of Pomegranate Juice Supplementation on Pulse Wave Velocity and Blood Pressure in Healthy Young and Middle-aged Men and Women. Plant Foods Hum Nutr, 67, 309-314.33. Tsang C, Smail NF, Almoosawi S, Davidson I, Al-Dujaili E. (2012). Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers. Journal of Nutritional Science, 1(9), 1-9.34. Shema-Didi L, Kristal B, Sela S, Geron R, Ore L. (2014). Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients? Nutrition Journal, 13, 1835. Asgary S, Sahebkar A, Afshani M.R, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M. (2014). Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects. Phytother Res, 28, 193–199.Ör: Baybek, H , Çatalkaya, D , Kıvrak, A , Tozak Yıldız, H . (2017). “Hemşirelik Öğrencilerinin Nanoteknoloji Tutumlarının Belirlenmesi.” Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6 (4), 1-11.
Year 2018, Volume: 7 Issue: 3, 50 - 56, 30.09.2018

Abstract

References

  • 1. Kearney PM, Whelton M, Reynolds K, Muntner P, Whelton PK, He J. (2005). Global burden of hypertension: analysis of worldwide data. Lancet, 365(9455), 217-23.2. Hajjar I, Kotchen JM, Kotchen TA. (2006). Hypertension: trends in prevalence, incidence, and control. Annu Rev Public Health, 27, 465-90.3. JNC-7 Guidelines. (2003). The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure. Hyper, 42, 1206.4. Lawes CM, Vander Hoorn S, Law MR, Elliott P, MacMahon S, Rodgers A. (2006). Blood pressure and the global burden of disease: part II. Estimates ofattributable burden, J. Hypertens, 24, 423–430.5. DeSimone ME, Crowe A. (2009). Nonpharmacological approaches in the management of hypertension. J Amer Acad N Pract, 21, 189-96.6. Wang X, Ouyang Y, Liu J, Zhu M, Zhao G, Bao W, Hu FB. (2014). Fruit and vegetableconsumption and mortality from all causes, cardiovascular disease, andcancer: systematic review and dose-response meta-analysis of prospectivecohort studies. BMJ, 349, g44907. Eilat-Adar S, Sinai T, Yosefy C, Henkin Y. (2013). Nutritional recommendations forcardiovascular disease prevention. Nutrients, 5 (9), 3646–3683.8. Grassi D, Desideri G, Ferri C. (2010). Flavonoids: antioxidants againstatherosclerosis, Nutrients, 2 (8), 889–902.9. Gil MI, Toma´s-Barbera´n FA, Hess-Pierce B, Holcroft DM, Kader AA. (2000). Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem, 48, 4581–4589.10. Basu A and Penugonda K. (2009). Pomegranate juice: a heart-healthy fruit juice. Nutrition Reviews, 67(1), 49–56.11. Shema-Didi L, Sela S, Ore L, Shapiro G, Geron R, Moshe G, et al. (2012). One year of pomegranate juice intake decreases oxidative stress, inflammation, and incidence of infections in hemodialysis patients: A randomized placebo-controlled trial. Free Radic Biol Med, 53, 297–30412. Yoon J-H, Baek SJ. (2005). Molecular Targets of Dietary Polyphenols with Anti-inflammatory Properties. Yonsei Medical Journal, 46(5), 585-596. 13. Johanningsmeier SD, Harris GK. (2011). Pomegranate as a functional food and nutraceutical source. Annu Rev Food Sci Technol, 2, 181–201.14. Ismail T, Sestili P, Akhtar S. (2012). Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J Ethnopharmacol, 143, 397–405.15. Trottier G, Bostrom PJ, Lawrentschuk N, Fleshner NE. (2010). Nutraceuticals and prostate cancer prevention: a current review. Nat Rev Urol, 7, 21–30.16. Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. (2004). Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food, 7(3), 305–308.17. Tzulker R, Glazer I, Bar-Ilan I, Holland D, Aviram M, Amir R. (2007). Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions. J Agric Food Chem, 55, 9559–9570.18. Rock W, Rosenblat M, Miller-Lotan R, Levy AP, Elias M, Aviram M. (2008). Consumption of wonderful variety pomegranate juice and extract by diabetic patients increases paraoxonase 1 association with high-density lipoprotein and stimulates its catalytic activities. J Agric Food Chem, 56, 8704–8713.19. Jurenka JS. (2008). Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev, 13, 128–44.20. Medjakovic S, Jungbauer A. (2013). Pomegranate: a fruit that ameliorates metabolic syndrome. Food Funct, 4, 19–39.21. Kelishadi R, Gidding SS, Hashemi M, Hashemipour M, Zakerameli A, Poursafa P. (2011). Acute and long term effects of grape and pomegranate juice consumption on endothelial dysfunction in pediatric metabolic syndrome. J Res Med Sci, 16(3), 245-53. 22. Rosenblat M, Volkova N, Aviram M. (2010). Pomegranate juice (PJ) consumption antioxidative properties on mouse macrophages, but not PJ beneficial effects on macrophage cholesterol and triglyceride metabolism, are mediated via PJ-induced stimulation of macrophage PON2. Atherosclerosis, 212(1), 86–92.23. Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. (2004). Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotidintima-media thickness, blood pressure and LDL oxidation. Clin Nutr, 23, 423–33.24. Rosenblat M, Hayek T, Aviram M. (2006). Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis, 187, 363–371.25. Parsaeyan N, Mozaffari-Khosravi H, Mozayan MR. (2012). Effect of pomegranate juice on paraoxonase enzyme activity in patients with type 2 diabetes. J Diabetes Metab Disord, 11(1), 11. 26. Aviram M, Dornfeld L. (2001). Pomegranate juice consumption inhibits serum angiotensin converting enzyme activity and reduces systolic blood pressure. Atherosclerosis, 158, 195–198.27. Razani Z, Dastani M, Kazerani HR. (2017). Cardioprotective Effects of Pomegranate (Punica granatum) Juice in Patients with Ischemic Heart Disease. Phytother Res, 31, 1731–1738. 28. Moher D, Pham B, Jones A, Cook DJ, Jadad AR, et al. (1998). Does quality of reports of randomised trials affect estimates of intervention efficacy reported in meta-analyses. Lancet, 352, 609–613.29. Sumner MD, Elliott-Eller M, Weidner G, Daubenmier JJ, Chew MH, et al. (2005). Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol, 96, 810–814.30. Moazzen H & Alizadeh M. (2017). Effects of Pomegranate Juice on Cardiovascular Risk Factors in Patients with Metabolic Syndrome: a Double-Blinded, Randomized Crossover Controlled Trial. Plant Foods Hum Nutr, 72, 126–133.31. Kojadinovic M, Arsic AC, Debeljak-Martacic JD, Konic-Ristic AI, Nevena Dj, Kardum, Popovic TB, Glibetic MD. (2017). Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. J Sci Food Agric, 97, 1798–1804.32. Lynn A, Hamadeh H, Leung WC, Russell JM, Barker ME. (2012). Effects of Pomegranate Juice Supplementation on Pulse Wave Velocity and Blood Pressure in Healthy Young and Middle-aged Men and Women. Plant Foods Hum Nutr, 67, 309-314.33. Tsang C, Smail NF, Almoosawi S, Davidson I, Al-Dujaili E. (2012). Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers. Journal of Nutritional Science, 1(9), 1-9.34. Shema-Didi L, Kristal B, Sela S, Geron R, Ore L. (2014). Does Pomegranate intake attenuate cardiovascular risk factors in hemodialysis patients? Nutrition Journal, 13, 1835. Asgary S, Sahebkar A, Afshani M.R, Keshvari M, Haghjooyjavanmard S, Rafieian-Kopaei M. (2014). Clinical Evaluation of Blood Pressure Lowering, Endothelial Function Improving, Hypolipidemic and Anti-Inflammatory Effects of Pomegranate Juice in Hypertensive Subjects. Phytother Res, 28, 193–199.Ör: Baybek, H , Çatalkaya, D , Kıvrak, A , Tozak Yıldız, H . (2017). “Hemşirelik Öğrencilerinin Nanoteknoloji Tutumlarının Belirlenmesi.” Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 6 (4), 1-11.
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Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Original Article
Authors

Melike Demir Doğan 0000-0001-7051-2202

Publication Date September 30, 2018
Published in Issue Year 2018 Volume: 7 Issue: 3

Cite

APA Demir Doğan, M. (2018). Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, 7(3), 50-56.
AMA Demir Doğan M. Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. September 2018;7(3):50-56.
Chicago Demir Doğan, Melike. “Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 7, no. 3 (September 2018): 50-56.
EndNote Demir Doğan M (September 1, 2018) Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 7 3 50–56.
IEEE M. Demir Doğan, “Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması”, Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, vol. 7, no. 3, pp. 50–56, 2018.
ISNAD Demir Doğan, Melike. “Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi 7/3 (September 2018), 50-56.
JAMA Demir Doğan M. Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2018;7:50–56.
MLA Demir Doğan, Melike. “Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması”. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi, vol. 7, no. 3, 2018, pp. 50-56.
Vancouver Demir Doğan M. Narın Kan Basıncı Üzerine Etkisi: Bir Meta Analiz Çalışması. Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi. 2018;7(3):50-6.