Evaluation of White Matter and Cerebellum Structures of Essential Tremor and Parkinson's Patients by Diffusion Tensor Imaging and Volbrain Method

Year 2023, Volume: 12 Issue: 4, 1887 - 1895, 26.12.2023

Özgür Palancı , Zekeriya Alioğlu , Ali Faruk Özyaşar , İlker Eyüboğlu , Elif Gökçen Köktürk Vildan Altunayoglu Cakmak

https://doi.org/10.37989/gumussagbil.1329521

Abstract

Essential tremor (ET) and Parkinson's disease (PD) are the two most commonly encountered tremor disorders in movement disorders. Diffusion tensor imaging (DTI) is one of the best in vivo ways of mapping white matter pathways in the human brain. The aim of our study was to investigate diffusion variables and cerebellum volume in ET and PD using parcellation methods. Our study included 20 ET, 20 PD and 20 healthy controls. Fraction Anisotropy (FA) and Mean Diffusivity (MD) values were obtained with DTI, while the volume of each lobe of the cerebellum was obtained with T1 images. One-way ANOVA was used for intergroup analysis and Scheffe test was used for post-hoc analysis. Significant differences were found in the diffusion values of the pedunculus cerebellaris, fornix stria, superior longitudinal fasciculus, sagittal stratum, cerebral pedunculus, tapatum and thalamus of ET and PD. Lobule V, Lobule IX, Lobule X volumes of the cerebellum showed significant differences between the groups. Stria thermialis shows involvement of mesolimbic dopaminergic system in PD and it is thought that disruption of strial networks leads to changes in the activity of cerebellar networks and reveals the role of the cerebellum in tremor. It is obvious that cerebellar thalamocortical pathways are affected in Parkinson's disease. In Parkinson's disease, patients should be evaluated for visual processing, conceptualisation, postural instability and gait disturbance to clarify the diagnosis or to differentiate from essential tremor.

Keywords

Diffusion tensor imaging, Essential tremor, Parkinson disease, Volbrain

Esansiyel Tremor ve Parkinson Hastalarında Beyaz Cevher ve Serebellum Yapılarının Difüzyon Tensör Görüntüleme ve Volbrain Yöntemi ile Değerlendirilmesi

Abstract

Esansiyel tremor (ET) ve Parkinson hastalığı (PH) hareket bozuklukları içinde en sık karşılaşılan iki tremor bozukluğudur. Difüzyon tensör görüntüleme (DTI), insan beynindeki beyaz madde yollarını haritalamanın en iyi in vivo yollarından biridir. Çalışmamızın amacı ET ve PH'da parselasyon yöntemlerini kullanarak difüzyon değişkenlerini ve serebellum hacmini araştırmaktır. Çalışmamıza 20 ET, 20 PH ve 20 sağlıklı kontrol dahil edildi. Fraksiyon Anizotropi (FA) ve Ortalama Difüzivite (MD) değerleri DTI ile elde edilirken, serebellumun her bir lobunun hacmi T1 görüntüleri ile elde edildi. Gruplar arası analiz için tek yönlü ANOVA ve post-hoc analiz için Scheffe testi kullanıldı. ET ve PD'de pedunculus cerebellaris, fornix stria, superior longitudinal fasciculus, sagittal stratum, serebral pedunculus, tapatum ve talamusun difüzyon değerlerinde anlamlı farklılıklar bulundu. Serebellumun Lobül V, Lobül IX, Lobül X hacimleri gruplar arasında anlamlı farklılıklar gösterdi. Stria thermialis, PH'da mezolimbik dopaminerjik sistemin tutulumunu gösterir ve strial ağların bozulmasının serebellar ağların aktivitesinde değişikliklere yol açtığı ve serebellumun tremordaki rolünü ortaya koyduğu düşünülmektedir. Parkinson hastalığında serebellar talamokortikal yolakların etkilendiği aşikardır. Parkinson hastalığında, tanıyı netleştirmek veya esansiyel tremordan ayırmak için hastalar görsel işleme, kavramsallaştırma, postüral instabilite ve yürüme bozukluğu açısından değerlendirilmelidir.

Keywords

Difüzyon tensor görüntüleme, Esansiyel tremor, Parkinson hastalığı, volbrain

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