Testis Tümörlü Hastalarda Tümör Grade İle Preoperatif Nötrofil Lenfosit Oranının İlişkisi

Yıl 2017, Cilt: 9 Sayı: 3, 158 - 168, 01.09.2017

Engin Kölükçü , Fikret Erdemir Şahin Kılıç Fatih Fırat İlker Etikan

Öz

Amaç:Bu çalışmada
testis tümörü sebebi ile opere edilen hastalarda nötrofil-lenfosit oranının
(NLO) postoperatif tümör evresini belirlemedeki etkisinin değerlendirilmesi
amaçlanmıştır.

Gereç ve Yöntem:Ocak 2006- Eylül
2017 yılları arasında primer testis tümörü nedeniyle orşiektomi yapılan 17
hastanın verileri retrospektif olarak incelendi. Çalışmaya alınan hastaların
yaşı, tümör histolojik tipi, patolojik evresi, serum nötrofil sayısı, serum
lenfosit sayısı ve nötrofil-lenfosit oranları kayıt edildi. T1 evre testis
tümörü olan hastalar grup 1, T2 evre ve üzeri testis tümörü olan hastalar ise
grup 2 olarak sınıflandırıldı. Bağımsız gruplarda Levenee testi kullanılarak
her iki grubun nötrofil-lenfosit oranları istatistiksel olarak karşılaştırıldı.

Bulgular: Hastaların
ortalama yaşları, ortalama kan nötrofil sayıları, lenfosit sayıları ve
nötrofil-lenfosit oranları sırasıyla 30.47±16.83 yıl, 6.1189±0.242 (K/uL),
2.4165±0.106 (K/uL) ve 2.88±1.8 idi. Histopatolojik incelemede, 3 (%17.64)
hastada saf seminom, 11 (%64.7) hastada mikst germ hücreli tümör, 2 (%11.74)
hastada yolk sac tümörü ve 1 (%5.88) hastada lenfoma olduğu belirlendi.
Hastaların 9 (%52.94)’unda T1, 8 (%47.05)’inde T2 ve üzeri hastalık izlendi.
Grup 1 ve 2'nin NLO’ları sırasıyla, 2.72 (SD:1.862) ve 3.05 (SD:1.913) idi. NLO
açısından değerlendirildiğinde iki grup arasında istatistiksel olarak anlamlı
fark izlenmedi. (p:0.723)

Sonuç: Çalışmada elde
edilen sonuçlara göre NLO, preoperatif olarak testis tümörü evresini
öngörememektedir. Ancak sonuçların desteklenmesi için daha fazla hasta sayılı
ve prospektif verilere ihtiyaç vardır.

Anahtar Kelimeler

Nötrofil-lenfosit oranı, testis tümörü, evresi

The Relationship Between Tumor Grade And Preoperatif Neuthrophil Lymphocyte Ratio In Patients with Tecticular Tumor

Öz

Aim: 
The effect of serum parameters on survival and tumor
stage still being investigated for cancer patients. In this study, we aimed to
evaluate the effect of neutrophil-lymphocyte ratio (NLR) in determining the
postoperative tumor stage in patients with testicular tumors.

Material and Methods: The
data of 17 patients who were performed orchiectomy for primary testicular tumor
at our clinic between January 2006 and Sempember 2017 was evaluated
retrospectively. Patients’ age, histological type of tumor, pathologic stage,
serum neutrophil, lymphocytecounts NLR values were recorded. Patients were
divided into two groups as Group 1 and 2, which contain stage T1 and stage T≥2
diseases, respectively. NLR of both groups were compared statistically using
the Levenee test for independent samples.

Results:
For all patients, mean age, mean serum neutrophil, lymphocyte value and mean
NLR were 30.47±16.83 years, 6.1189±0.242 (K/uL), 2.4165±0.106 (K/uL) and
2.88±1.8 respectively. Pathologic examination revealed pure seminoma in 3
(%17.64) patients, mixed germ cell tumor in 11 (%64.7) patients, yolk sac tumor
in 2 (%11.74)  patients, lymphoma in 1
(%5.88) patient. T 1 disease and T ≥2 disease were revealed in 9 (%52.94) and 8
(%47.05) of the patients. The NLR for groups 1 and 2 were 2.72 (SD:1.862) and
3.05 (SD:1.913) respectively. There was no statistically significant difference
between both groups regarding the NLR. (p:0.723)

Conclusion:
NLR could not predict the pathological stage of testicular tumor
preoperatively. However, high patient volume and prospective trails are needed
to support our results.

Anahtar Kelimeler

Neutrophil-lymphocyte ratio, testicular tumor, stage

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