Dalak ve Karaciğer Tutulumu ile Seyreden T Hücre/ Histiyositten Zengin B Hücreli Lenfoma Olgusu

Year 2017, Volume: 9 Issue: 4, 304 - 309, 01.12.2017

Ayşe Kevser Demir , Ayşe Kefeli Ali Akın , Şafak Şahin Eda Albayrak Sedanur Kurban Memiş Hilmi Atay

Abstract

T hücre/Histiyositten zengin B hücreli lenfoma (TC/HRBCL), diffüz büyük
B-hücreli lenfoma (DBBHL)’nin son zamanlarda tanınmış morfolojik bir
varyantıdır. DLBCL’lerin %2’den azını oluşturur. Diğer DLBCL alt tiplerine göre
daha erken yaşlarda görülür ve sıklıkla erkek bireyler etkilenir. Bu sunumda
diffüz karaciğer ve dalak tutulumu olan TC/HRBCL tanısı almış otuz üç yaşında
erkek bir olgunun klinik ve radyolojik bulgularının sunumu yapılmaktadır.

Keywords

T hücre/Histiyositten zengin B hücreli lenfoma, karaciğer tutulumu

T-Cell/Histiocyte-Rich B-Cell Lymphoma with Spleen and Liver Involvement

Abstract

T-Cell/Histiocyte-Rich B-Cell Lymphoma (TC/HRBCL) is a recently recognized
morphological variant of diffuse large B-cell lymphoma (DBBHL). It is compose
of less than 2% of DLBCLs. It is seen at earlier ages than other DLBCL subtypes
and is often affected by male subjects. In this presentation, we present
clinical and radiological findings of a thirty-three-year-old male patient with
a diagnosis of TC/HRBCL with diffuse liver and spleen involvement.

Keywords

T-Cell/Histiocyte-Rich B-Cell Lymphoma, liver involvement

References

• 1. Diffüz büyük B hücreli lenfoma tanı ve tedavi kılavuzu. 2016.
• 2. Anderson T, Chabner BA, Young RC, et al. Malignant lymphoma. 1.The histology and staging of 473 patients at the National Cancer Institute. Cancer. 1982;50:2699-707.
• 3. Ferhanoğlu B. Diffüz büyük B hücreli lenfomalar - klinik ve tedavi. Türk Hematoloji Derneği Klinisyen-Patolog Ortak Lenfoma Kursu. 2004; 54-62.
• 4. Greer JP, Macon WR, Lamar RE, Wolff SN, Stein RS, et al. T-cell-rich large B-cell lymphomas: Diagnosis and response to therapy of 44 patients. J Clin Oncol. 1995;13: 1742-50.
• 5. Abramson JS. T-cell/histiocyte-rich B-cell lymphoma: biology, diagnosis and management. The Oncologist. 2006;11:384-92.
• 6. Jaffe ES.The 2008 WHO classification of lymphomas: implications for clinical practice and translational research.Hematology Am Soc Hematol Educ Program. 2009:523-31.
• 7. Ramsay AD, Smith WJ, Isaacson PG. T-cell rich B-cell lymphoma. Am J Surg Pathol. 1988;12:433-43.
• 8. His ED, Hematopathology.1th ed.Philadelphıa, Churcil Livingstone, 2007:259-82.
• 9. Schmidt U, Metz KA, Leder LD. T-cell-rich large B-cell lymphoma and lympocyte predominant Hodgkin’s disease: two closely related entities. Br J Haematol. 1995;90:398-403.
• 10. McBride JA, Rodriguez J, Luthra R, et al. T-cell-rich B large cell lymphoma simulating lymphocyte-rich Hodgkin’s disease. Am J Surg Pathol. 1996;20:193-201.
• 11. Ripp JA, Louie DC, Chan W, Nawaz H, Portlock CS. T-cell rich B-cell lymphoma: clinical distinctiveness and response to treatment in 45 patients. Leuk Lymphoma. 2002;43:1573-80.
• 12. Weshi Amr E, Akhtar S, Mourad W A, Ajarım D, Abdelsalm M. T-cell/histiocyte-rich B-cell lymphoma: Clinical presentation, management and prognostic factors: report on 61 patients and review of literature. Leukemia&Lymphoma. 2007;48:1764-73.