Propofol Enjeksiyon Ağrısının Önlenmesinde Deksketoprofen ve Tenoksikamın Etkileri

Yıl 2018, Cilt: 10 Sayı: 2, 71 - 82, 01.06.2018

Özgür Yağan , Tuğçe Mutlu Ebru Çanakçı Nilay Taş B. Serhan Yurtlu Volkan Hancı

Öz

Amaç: Çalışmamızın amacı propofol
enjeksiyon ağrısının önlenmesinde tenoksikam ve deksketoprofenin etkinliğini
araştırmaktır.Metod: Çalışmaya 20-60 yaş arası 150 hastanın dahil edilmesi
planlandı. Hastalar randomize olarak 3 gruba ayrıldı. Genel anestezi
indüksiyonu için iv olarak propofol uygulanmasından 2 dk önce hastalara; Grup
I’de 2 mL salin, Grup II’de 20 mg (2mL) tenoksikam, Grup III’te ise 50 mg (2mL)
deksketoprofen uygulandı. Hesaplanan propofol dozunun 4’te 1’inin uygulanması
sonrası enjeksiyon ağrısı 4 puanlı verbal derecelendirme skalası (VRS) ve
nümerik değerlendirme skalası (NRS) ile değerlendirildi. Bulgular:
Deksketoprofen grubu, çalışma ilacı uygulaması esnasında hastaların şiddetli
ağrı duyması nedeniyle 18. hastada sonlandırıldı. Toplam 118 hastanın verileri
değerlendirildi. Propofol enjeksiyon ağrısı sıklığı salin grubunda %76,
tenoksikam grubunda ise %38 idi ve fark istatistiksel olarak anlamlıydı
(p<0,01). NRS skorları salin grubunda 3,1±2,2, tenoksikam grubunda
1,7±1,7 ve deksketoprofen grubunda 1,9±1,5 idi ve salin grubunda tenoksikam ve
deksketoprofen grubu ile karşılaştırıldığında istatistiksel olarak anlamlı
şekilde yüksekti (sırasıyla p<0,01 ve p<0,05). Sonuç: Çalışmamız
sonucunda 20 mg iv tenoxicam ön tedavisinin, propofol enjeksiyon ağrısını
azaltmada etkili olduğunu tespit ettik.

Anahtar Kelimeler

Deksketoprofen, enjeksiyon ağrısı, propofol, tenoksikam

The Effect of Intravenous Dexketoprofen and Tenoxicam on Propofol Injection Pain

Öz

Background and Objectives: The aim
of our study is to research the efficacy of tenoxicam and dexketoprofen in
preventing propofol injection pain. Methods: The study included 150 patients
aged from 20 to 60 years. The patients were randomly divided into 3 groups. Two
minutes before iv propofol administration for induction of general anesthesia
patients in Group I were given 2 mL saline, patients in Group II were given 20
mg (2 mL) tenoxicam and patients in Group III were given 50 mg (2 mL)
dexketoprofen. After administering 1 quarter of the calculated propofol dose
injection pain severity was assessed using a four-point verbal rating scale
(VRS) and numeric rating scale (NRS).Results: Due to pain felt during
administration of the study medication in the dexketoprofen group, the study
was terminated after 18 patients. The data from 118 patients were assessed. The
incidence of propofol injection pain in the saline group was 76%, while this
was 38% in the tenoxicam group and the difference was statistically significant
(p<0.01). NRS score was 3.1±2.2 in the saline group, 1.7±1.7 in the
tenoxicam group and 1.9±1.5 in the dexketoprofen group and it was statistically
significantly higher in the saline group compared to the tenoxicam and
dexketoprofen groups (p<0.01 and p<0.05 respectively).
Conclusions: At the end of our study we identified that 20 mg iv tenoxicam
pretreatment was effective in reducing propofol injection pain.

Anahtar Kelimeler

Dexketoprofen, injection pain, propofol, tenoxicam

Kaynakça

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