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Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi

Year 2022, Volume: 14 Issue: 3, 181 - 190, 10.01.2023

Abstract

Amaç: Şanlıurfa ilinde 3. Basamak hastanemizde Hashimoto tiroiditi tanısıyla takip edilen hastaların klinik, demografik, laboratuvar özelliklerinin değerlendirilmesi.
Yöntem: Çalışmaya Mayıs 2019 – Eylül 2020 tarihleri arasında prospektif olarak Dahiliye ve Endokrinoloji Poliklinikleri’ ne başvuran hashimoto tiroiditi tanılı 48 hasta ve 40 sağlıklı gönüllü olmak üzere toplam 88 kişi dahil edildi. Çalışma süresince hastaların ayrıntılı anamnezi, fizik muayeneleri, demografik verileri kayıt altına alındı. Hastaların tansiyonu, boy ve kiloları ölçüldü, vücut kitle indekleri hesaplandı, hemogram ve biyokimya parametreleri değerlendirildi.
Bulgular: Yaş, cinsiyet ve vücut kitle indeksi olarak gruplar arasında anlamlı farklılık yoktu. Ferritin düzeyi ve D vitamini düzeyi hasta grubunda kontrol grubuna göre sırasıyla (p= 0.00), (p= 0.00) istatistiksel olarak anlamlı düşük saptandı. Total kolesterol ve LDL düzeyleri hasta grubunda kontrol grubuna göre sırasıyla (p= 0.00), (p= 0.00) istatistiksel olarak anlamlı yüksek saptandı.
Sonuç: Hashimoto tiroiditi etyolojisi net olarak saptanamamış otoimmün bir hastalıktır. HT’ nin kliniğinde vitamin eksiklikleri, anemi ve dislipidemi önemli bir yere sahiptir. Çalışmamız da göstermiştir ki hastaların takibinde akılda tutulmalıdır.

References

  • 1. Thyroid Study Group. Turkey Endokirn and Metabolism Association (SEMT) Thyroid Disease Diagnosis and Treatment Guideline Turkey Clinics; 2019.
  • 2. Gedik O. Endocrine and Metaboism Diseases. In: Sonmez HM, Iliçin G, Biberoğlu K, Süleymanlar G, Ünal S, eds. Internal Diseases Abstract Book.; 2017: 825-54.
  • 3. Tunbridge W, Evered D, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clinical endocrinology. 1977;7(6):481-93.
  • 4. Fauci AS KD, Longo L, Braunwald E, Hauser SL, Jameson JL. Harrison’s Principles of İnternal Medicine 2013;2230-2
  • 5. McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012;42(2):252-65.
  • 6. Vanderpump MP. The epidemiology of thyroid disease. British medical bulletin.2011;99(1):
  • 7. Hennessey JV. Clinical review: Riedel's thyroiditis: a clinical review. J. Clin. Endocrinol. Metab. 2011 Oct;96(10):3031-41.
  • 8. Corapoğlu D, Uysal AR, Çetinarslan B, BAŞKAL N. Hashimoto with thyroiditis clinical and laboratory evaluation of our cases. Ankara University Medicine Faculty Magazine. 1996; 49 (01):
  • 9. Wang C, Crapo LM. The epidemiology of thyroid disease and implications for screening. Endocrinology and Metabolism Clinics. 1997; 26(1):189-218.
  • 10. Tunbridge WMG, Vanderpump MP. Population screening for autoimmune thyroid disease. Endocrinology and Metabolism Clinics. 2000; 29(2):239-53.
  • 11. Aksu O, Aydin B, Koroglu BK, Tamer MN. An evaluation of the neutrophil/lymphocyte ratio in patients with Hashimoto’s thyroiditis. Acta Medica Mediterr. 2014; 30:457-60.
  • 12. Arık S. 25 Hydroxy Vitamin D and Parathyroid Hormone in Hashimoto Thyroiditis Level (Specialization thesis). Istanbul –2008.
  • 13. Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY: Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. The Journal of Clinical Investigation 2007; 117(7):1933-9.
  • 14. Caplan, Robert H., et al. "Serum folate and vitamin B12 levels in hypothyroid and hyperthyroid patients." Archives of internal medicine 1975; 135(5): 701-4.
  • 15. Dunn JT & Dunn AD Update on intrathyroidal iodine metabolism. Thyroid 2001; 11: 407– 14.
  • 16. Hess SY, Zimmermann MB, Arnold M et al. Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr 2002; 132: 1951–5.
  • 17. Fayadat L, Niccoli-Sire P, Lanet J et al. Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme binding. J Biol Chem 1999; 274: 10533–8.
  • 18. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism. Exp Clin Endocrino Diabetes 1999;107:356-60.
  • 19. Horton, L., et al. "The haematology of hypothyroidism." QJM: An International Journal of Medicine 1976; 45(1): 101-23.
  • 20. Guyton AC, H., J.E, Medical Physiology. Nobel Medical Bookstores Thyroid Metabolic Hormones, Istanbul. 2007; 931-40.
  • 21. Pirich C, Müllner M, Sinzinger H. Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants. Journal of Clinical Epidemiology. 2000; 53:623-9.
  • 22. Bauer DC, Ettinger B, Browner W. Thyroid functions and serum lipits in older women: a population-based study, S. The American Journal of Medicine. 1998; 104: 546-51.
  • 23. Cheserek M., Wu G., Ntazinda A., Shi Y. Association between thyroid hormones, lipits and oxıdative stress markers in subclinical hypothyroidism.Journal Medical Biochemistry. 2015; 34(3): 323-31.
  • 24. Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clinical Endocrinology. 2014; 61(2): 232-8.
  • 25. Muscogiuri G, Tirabassi G, Bizzaro G, Orio F, Paschou SA, Vryonidou A, et al. Vitamin D and thyroid disease: to D or not to D? European journal of clinical nutrition. 2015; 69(3):291- 6.
  • 26. Vondra K, Starka L, Hampl R. Vitamin D and thyroid diseases. Physiological research. 2015; 64(2): 95-100.

Retrospective Evaluation of Clinical and Laboratory Characteristics of Patients Diagnosed with Hashimoto's Thyroiditis

Year 2022, Volume: 14 Issue: 3, 181 - 190, 10.01.2023

Abstract

References

  • 1. Thyroid Study Group. Turkey Endokirn and Metabolism Association (SEMT) Thyroid Disease Diagnosis and Treatment Guideline Turkey Clinics; 2019.
  • 2. Gedik O. Endocrine and Metaboism Diseases. In: Sonmez HM, Iliçin G, Biberoğlu K, Süleymanlar G, Ünal S, eds. Internal Diseases Abstract Book.; 2017: 825-54.
  • 3. Tunbridge W, Evered D, Hall R, Appleton D, Brewis M, Clark F, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clinical endocrinology. 1977;7(6):481-93.
  • 4. Fauci AS KD, Longo L, Braunwald E, Hauser SL, Jameson JL. Harrison’s Principles of İnternal Medicine 2013;2230-2
  • 5. McLeod DS, Cooper DS. The incidence and prevalence of thyroid autoimmunity. Endocrine. 2012;42(2):252-65.
  • 6. Vanderpump MP. The epidemiology of thyroid disease. British medical bulletin.2011;99(1):
  • 7. Hennessey JV. Clinical review: Riedel's thyroiditis: a clinical review. J. Clin. Endocrinol. Metab. 2011 Oct;96(10):3031-41.
  • 8. Corapoğlu D, Uysal AR, Çetinarslan B, BAŞKAL N. Hashimoto with thyroiditis clinical and laboratory evaluation of our cases. Ankara University Medicine Faculty Magazine. 1996; 49 (01):
  • 9. Wang C, Crapo LM. The epidemiology of thyroid disease and implications for screening. Endocrinology and Metabolism Clinics. 1997; 26(1):189-218.
  • 10. Tunbridge WMG, Vanderpump MP. Population screening for autoimmune thyroid disease. Endocrinology and Metabolism Clinics. 2000; 29(2):239-53.
  • 11. Aksu O, Aydin B, Koroglu BK, Tamer MN. An evaluation of the neutrophil/lymphocyte ratio in patients with Hashimoto’s thyroiditis. Acta Medica Mediterr. 2014; 30:457-60.
  • 12. Arık S. 25 Hydroxy Vitamin D and Parathyroid Hormone in Hashimoto Thyroiditis Level (Specialization thesis). Istanbul –2008.
  • 13. Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY: Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. The Journal of Clinical Investigation 2007; 117(7):1933-9.
  • 14. Caplan, Robert H., et al. "Serum folate and vitamin B12 levels in hypothyroid and hyperthyroid patients." Archives of internal medicine 1975; 135(5): 701-4.
  • 15. Dunn JT & Dunn AD Update on intrathyroidal iodine metabolism. Thyroid 2001; 11: 407– 14.
  • 16. Hess SY, Zimmermann MB, Arnold M et al. Iron deficiency anemia reduces thyroid peroxidase activity in rats. J Nutr 2002; 132: 1951–5.
  • 17. Fayadat L, Niccoli-Sire P, Lanet J et al. Role of heme in intracellular trafficking of thyroperoxidase and involvement of H2O2 generated at the apical surface of thyroid cells in autocatalytic covalent heme binding. J Biol Chem 1999; 274: 10533–8.
  • 18. Duntas LH, Papanastasiou L, Mantzou E, Koutras DA. Incidence of sideropenia and effects of iron repletion treatment in women with subclinical hypothyroidism. Exp Clin Endocrino Diabetes 1999;107:356-60.
  • 19. Horton, L., et al. "The haematology of hypothyroidism." QJM: An International Journal of Medicine 1976; 45(1): 101-23.
  • 20. Guyton AC, H., J.E, Medical Physiology. Nobel Medical Bookstores Thyroid Metabolic Hormones, Istanbul. 2007; 931-40.
  • 21. Pirich C, Müllner M, Sinzinger H. Prevalence and relevance of thyroid dysfunction in 1922 cholesterol screening participants. Journal of Clinical Epidemiology. 2000; 53:623-9.
  • 22. Bauer DC, Ettinger B, Browner W. Thyroid functions and serum lipits in older women: a population-based study, S. The American Journal of Medicine. 1998; 104: 546-51.
  • 23. Cheserek M., Wu G., Ntazinda A., Shi Y. Association between thyroid hormones, lipits and oxıdative stress markers in subclinical hypothyroidism.Journal Medical Biochemistry. 2015; 34(3): 323-31.
  • 24. Kvetny J, Heldgaard PE, Bladbjerg EM, Gram J. Subclinical hypothyroidism is associated with a low-grade inflammation, increased triglyceride levels and predicts cardiovascular disease in males below 50 years. Clinical Endocrinology. 2014; 61(2): 232-8.
  • 25. Muscogiuri G, Tirabassi G, Bizzaro G, Orio F, Paschou SA, Vryonidou A, et al. Vitamin D and thyroid disease: to D or not to D? European journal of clinical nutrition. 2015; 69(3):291- 6.
  • 26. Vondra K, Starka L, Hampl R. Vitamin D and thyroid diseases. Physiological research. 2015; 64(2): 95-100.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Research Article
Authors

Ali Gökçe

Çiğdem Cindoğlu This is me

Burcu Dikeç Gökçe This is me

Mehmet Ali Eren This is me

Publication Date January 10, 2023
Published in Issue Year 2022 Volume: 14 Issue: 3

Cite

APA Gökçe, A., Cindoğlu, Ç., Dikeç Gökçe, B., Eren, M. A. (2023). Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, 14(3), 181-190.
AMA Gökçe A, Cindoğlu Ç, Dikeç Gökçe B, Eren MA. Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi. Gaziosmanpaşa Tıp Dergisi. January 2023;14(3):181-190.
Chicago Gökçe, Ali, Çiğdem Cindoğlu, Burcu Dikeç Gökçe, and Mehmet Ali Eren. “Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik Ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 14, no. 3 (January 2023): 181-90.
EndNote Gökçe A, Cindoğlu Ç, Dikeç Gökçe B, Eren MA (January 1, 2023) Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 14 3 181–190.
IEEE A. Gökçe, Ç. Cindoğlu, B. Dikeç Gökçe, and M. A. Eren, “Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi”, Gaziosmanpaşa Tıp Dergisi, vol. 14, no. 3, pp. 181–190, 2023.
ISNAD Gökçe, Ali et al. “Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik Ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi 14/3 (January 2023), 181-190.
JAMA Gökçe A, Cindoğlu Ç, Dikeç Gökçe B, Eren MA. Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi. Gaziosmanpaşa Tıp Dergisi. 2023;14:181–190.
MLA Gökçe, Ali et al. “Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik Ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi”. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Dergisi, vol. 14, no. 3, 2023, pp. 181-90.
Vancouver Gökçe A, Cindoğlu Ç, Dikeç Gökçe B, Eren MA. Hashimoto Tiroiditi Tanısı Alan Hastaların Klinik ve Laboratuvar Özelliklerinin Retrospektif Olarak Değerlendirilmesi. Gaziosmanpaşa Tıp Dergisi. 2023;14(3):181-90.

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